Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 931 to 960 publications on 1006 in total

Actinomyces pyogenes: susceptibility of 103 clinical animal isolates to 22 antimicrobial agents

V Guérin-Faublée, Jp Flandrois, E Broye, F Tupin, Y Richard

Veterinary Research . 24 ( 3 ) : 251-259

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Mathematical model for comparison of time-killing curves.

F Guerillot, G. Carret, Jean-Pierre Flandrois

Antimicrobial Agents and Chemotherapy . 37 ( 8 ) : 1685-1689

DOI: 10.1128/AAC.37.8.1685

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Antimicrobial susceptibility testing of actinomyces pyogenes: Comparison of disk diffusion test and Api ATB Strep system with the Agar dilution method

Véronique Guérin-Faublée, Jean-Pierre Flandrois, Yves Richard

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 279 ( 3 ) : 377-386

DOI: 10.1016/S0934-8840(11)80370-1

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A statistical evaluation of the bactericidal effects of ceftibuten in combination with aminoglycosides and ciprofloxacin

F. Guérillot, G. Carret, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 32 ( 5 ) : 685-694

DOI: 10.1093/jac/32.5.685

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[Comparative study of two systems for the determination of the sensitivity of yeasts to antifungal agents].

M de Montclos, H. de Montclos, Jean-Pierre Flandrois

Pathologie Biologie . 40 ( 5 ) : 495-9

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Gram-positive infections in neutropenic patients: glycopeptide antibiotic choice

Monique Chomarat, Daniel Espinouse, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 29 ( 4 ) : 462-463

DOI: 10.1093/jac/29.4.462

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Comparative variation of morphological and molecular evolution through geologic time: 28S ribosomal RNA versus morphology in echinoids.

Andrew B. Smith, Bénédicte Lafay, Richard Christen

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990) . 338 ( 1286 ) : 365-82

DOI: 10.1098/rstb.1992.0155

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Phylogenetic analysis of the pathogenic anaerobe Clostridium perfringens using the 16S rRNA nucleotide sequence.

Bruno Canard, Thierry Garnier, Bénédicte Lafay, Richard Christen, Stewart T. Cole

International Journal of Systematic Bacteriology . 42 ( 2 ) : 312-4

DOI: 10.1099/00207713-42-2-312

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Insect muscle actins differ distinctly from invertebrate and vertebrate cytoplasmic actins

N. Mounier, Manolo Gouy, Dominique Mouchiroud, J.C. Prudhomme

Journal of Molecular Evolution . 34 : 406-415

DOI: 10.1007/BF00162997

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Evolution of the primate beta-globin gene region: nucleotide sequence of the delta-beta-globin intergenic region of gorilla and phylogenetic relationships between African apes and man

P. Perrin-Pecontal, Manolo Gouy, V.M. Nigon, G. Trabuchet

Journal of Molecular Evolution . 34 : 17-30

DOI: 10.1007/BF00163849

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Monod's bacterial growth model revisited

J.R. Lobry, Jean-Pierre Flandrois, G. Carret, A. Pavé

Bulletin of Mathematical Biology . 54(1) : 117-122

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Maintenance requirements of Escherichia coli ATCC 25922 in the presence of sub-inhibitory concentrations of various antibiotics

J.R. Lobry, G. Carret, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 29 : 121-127

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Marinobacter hydrocarbonoclasticus gen. nov., sp. nov., a new, extremely halotolerant, hydrocarbon-degrading marine bacterium.

Michel J. Gauthier, Bénédicte Lafay, Richard Christen, Luis Fernandez, M. Acquaviva, Patricia Bonin...

International Journal of Systematic Bacteriology . 42 ( 4 ) : 568-76

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An analysis of partial 28S ribosomal RNA sequence suggests early radiations of sponges

Bénédicte Lafay, Nicole Boury-Esnault, Jean Vacelet, Richard Christen

BioSystems . 28 : 139-151

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A FORTRAN subroutine for the determination of parameter confidence limits in non-linear Models

J.R. Lobry, L. Rosso, Jean-Pierre Flandrois

Binary . 3 : 86-93

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Susceptibility to Aminoglycosides of 63 Strains of Stomatococcus mucilaginosus Isolated from Sputum

Monique Chomarat, Marie-Gabrielle Vital, Jean-Pierre Flandrois

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 276 ( 1 ) : 63-67

DOI: 10.1016/S0934-8840(11)80219-7

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[Expert systems and antibiotic sensitivity test].

Jean-Pierre Flandrois, G. Carret

Annales de Biologie Clinique . 49 ( 3 ) : 166-71

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Coagulase-negative staphylococci emerging during teicoplanin therapy and problems in the determination of their sensitivity

Monique Chomarat, Daniel Espinouse, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 27 ( 4 ) : 475-480

DOI: 10.1093/jac/27.4.475

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Identification des organismes et construction de phylogénies moléculaires par comparaison de séquences d'acides nucléiques

Richard Christen, Bénédicte Lafay, Philippe Elbaze, Valérie Boivin, Valérie O. Cilia

Océanis : Série de documents océanographiques . 17 ( 3 ) : 239-256

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Regulation of the acetate operon in Escherichia coli: purification and functional characterization of the IclR repressor.

Jc Cortay, D. Negre, A. Galinier, B. Duclos, G. Perriere, Aj Cozzone

EMBO Journal . 10 : 675-679

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Primary structure of the intergenic region between aceK and iclR in the Escherichia coli chromosome.

A. Galinier, F. Bleicher, D. Negre, G. Perriere, B. Duclos, Aj Cozzone...

Gene . 97 : 149-150

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Comparison of estimates of Monod's growth model from the same data set

J.R. Lobry, Jean-Pierre Flandrois

Binary . 3 : 20-23

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Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B

M. Peyret, Jean-Pierre Flandrois, G. Fardel

Pathologie Biologie . 39 : 446-450

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Etude sur quatre ans des cas de yersiniose dans un service d'hépato-gastro-entérologie de la région lyonnaise

Jean-Pierre Flandrois, F. Bailly, M. Peyret, L. Descos

Médecine et Maladies Infectieuses . 21 : 371-375

DOI: 10.1016/S0399-077X(05)81308-3

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[Influence of the culture medium (Isosensitest or Mueller-Hinton) on the results of antibiotics susceptibility testing and its interpretation].

Jean-Pierre Flandrois, M. Peyret, J Zindel

Pathologie Biologie . 39 ( 5 ) : 455-60

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[Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B].

M. Peyret, Jean-Pierre Flandrois, G. Fardel

Pathologie Biologie . 39 ( 5 ) : 446-50

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Biphasic kinetics of bacterial killing by quinolones

G. Carret, Jean-Pierre Flandrois, Jean R Lobry

Journal of Antimicrobial Chemotherapy . 27 ( 3 ) : 319-327

DOI: 10.1093/jac/27.3.319

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