Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 901 to 930 publications on 1005 in total

Inferring phylogenies from DNA sequences of unequal base compositions.

N. Galtier, Manolo Gouy

Proceedings of the National Academy of Sciences of the United States of America . 92 ( 24 ) : 11317-11321

DOI: 10.1073/pnas.92.24.11317

Journal article

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Olecranon bursitis due toPrototheca wickerhamii, an algal opportunistic pathogen

M. Montclos, G. Chatte, M. Perrin-Fayolle, Jean-Pierre Flandrois

European Journal of Clinical Microbiology and Infectious Diseases . 14 ( 6 ) : 561-562

DOI: 10.1007/bf02113444

Journal article

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The effect of incubation temperature and sodium chloride concentration on the growth kinetics of Vibrio anguillarum and Vibrio anguillarum -related organisms

Véronique Guérin-Faublée, L. Rosso, Martine Vigneulle, J.-P. Flandrois

The Journal of applied bacteriology . 78 ( 6 ) : 621-629

DOI: 10.1111/j.1365-2672.1995.tb03108.x

Journal article

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Roseobacter algicola sp. nov., a new marine bacterium isolated from the phycosphere of the toxin-producing dinoflagellate Prorocentrum lima.

Bénédicte Lafay, Raymond Ruimy, Catherine Rausch de Traubenberg, Violette Breittmayer, Michel J. Gauthier, Richard Christen

International Journal of Systematic Bacteriology . 45 ( 2 ) : 290-6

Journal article

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A combined morphological and molecular approach to the phylogeny of asteroids (Asteroidea: Echinodermata)

Bénédicte Lafay, Richard Christen, Andrew B. Smith

Systematic Biology . 44 ( 2 ) : 190-208

Journal article

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Statistical analysis of vertebrate sequences reveals that long genes are scarce in GC-rich isochores

L. Duret, Dominique Mouchiroud, Christian Gautier

Journal of Molecular Evolution . 40 : 308-317

Journal article

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Convenient Model To Describe the Combined Effects of Temperature and pH on Microbial Growth

L. Rosso, J.R. Lobry, S. Bajard, Jean-Pierre Flandrois

Applied and Environmental Microbiology . 61 : 610-616

Journal article

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Small-subunit rRNA sequences and whole DNA relatedness concur for the reassignment of Pasteurella piscicida (Snieszko et al.) Janssen and Surgalla to the genus Photobacterium as Photobacterium damsela subsp. piscicida comb. nov.

Gilles Gauthier, Bénédicte Lafay, Raymond Ruimy, Violette Breittmayer, Jean-Louis Nicolas, Richard Christen

International Journal of Systematic Bacteriology . 45 ( 1 ) : 139-44

Journal article

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Ophiuroid phylogeny and higher taxonomy: morphological, molecular and palaeontological perspectives

Andrew B. Smith, Gordon L.J. Paterson, Bénédicte Lafay

Zoological Journal of the Linnean Society . 114 : 213-243

Journal article

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Accuracy of microbial growth predictions with square root and polynomial models

Jean-Pierre Flandrois, M. Delignette-Muller

International Journal of Food Microbiology . 27 ( 2-3 ) : 139-146

DOI: 10.1016/0168-1605(94)00158-3

Journal article

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Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias

R. Rimokh, F. Berger, C. Bastard, B. Klein, M. French, E. Archimbaud...

Blood . 83 : 3689-3696

Journal article

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NRSub: a non-redundant data base for the Bacillus subtilis genome

G. Perrière, Manolo Gouy, T. Gojobori

Nucleic Acids Research . 22 ( 25 ) : 5525-5529

DOI: 10.1093/nar/22.25.5525

Journal article

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HOVERGEN: a database of homologous vertebrate genes

L. Duret, Dominique Mouchiroud, Manolo Gouy

Nucleic Acids Research . 22 ( 12 ) : 2360-2365

DOI: 10.1093/nar/22.12.2360

Journal article

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Molecular Phylogenetic Analysis of Nitrobacter spp

S. Orso, Manolo Gouy, E. Navarro, P. Normand

International Journal of Systematic Bacteriology . 44 ( 1 ) : 83-86

DOI: 10.1099/00207713-44-1-83

Journal article

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Heterogeneity of hepatitis C virus genotypes in France

D. Qu, O. Hantz, Manolo Gouy, L. Vitvitski, J.S. Li, F. Berby...

Journal of General Virology . 75 ( Pt 5) : 1063-1070

DOI: 10.1099/0022-1317-75-5-1063

Journal article

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Phylogenetic analysis and assessment of the genera Vibrio, Photobacterium, Aeromonas, and Plesiomonas deduced from small-subunit rRNA sequences.

Raymond Ruimy, Violette Breittmayer, Philippe Elbaze, Bénédicte Lafay, Odile Boussemart, Michel Gautier...

International Journal of Systematic Bacteriology . 44 ( 3 ) : 416-26

Journal article

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Mathematical model of the interactions between Micrococcus spp. and Pseudomonas aeruginosa on agar surface

J.-P. Flandrois, Catherine Chapuis

The Journal of applied bacteriology . 77 ( 6 ) : 727-732

DOI: 10.1111/j.1365-2672.1994.tb02826.x

Journal article

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[Post-antibiotic effect of three aminoglycosides against Klebsiella pneumoniae].

M de Montclos, M. Guinet, Jean-Pierre Flandrois, Catherine Chapuis

Pathologie Biologie . 42 ( 5 ) : 419-24

Journal article

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An accurate diffusion method for determining bacterial sensitivity to antibiotics

M. Delignette-Muller, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 34 ( 1 ) : 73-81

DOI: 10.1093/jac/34.1.73

Journal article

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Molecular phylogeny of Eubacteria: a new multiple tree analysis method applied to 15 sequence data sets questions the monophyly of Gram-positive bacteria

N. Galtier, Manolo Gouy

Research in Microbiology . 145 ( 7 ) : 531-541

DOI: 10.1016/0923-2508(94)90030-2

Journal article

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ColiGene: object-centered representation for the study of E coli gene expressivity by sequence analysis

G. Perrière, Christian Gautier

Biochimie . 75 : 415-422

Journal article

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Building large knowledge bases in molecular biology

O. Schmeltzer, C. Medigue, P. Uvietta, F. Rechenmann, F. Dorkeld, G. Perrière...

In Proceedings of the First International Conference on Intelligent Systems for Molecular Biology . 1 : 345-353

Journal article

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Morphological and molecular phylogeny of ophiuroids

Andrew B. Smith, Bénédicte Lafay, Gordon L.J. Paterson

Eigth International Echinoderm Conference .

Conference paper

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An analysis of partial 28S ribosomal RNA sequence suggests early radiations within the phylum Porifera

Bénédicte Lafay, Nicole Boury-Esnault, Jean Vacelet, Richard Christen

4th International Porifera Congress "Sponges in Time and Space" .

Conference paper

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Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions

Jean-Pierre Rouault, J.P. Rouault, C. Samarut, L. Duret, C. Tessa, J. Samarut...

Gene . 129 ( 2 ) : 303-306

DOI: 10.1016/0378-1119(93)90284-A

Journal article

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Object-oriented knowledge bases for the analysis of prokaryotic and eukaryotic genomes

G. Perrière, F. Dorkeld, F. Rechenmann, Christian Gautier

In Proceedings of the 1st International Conference on Intelligent Systems for Molecular Biology . 1 : 319-327

Journal article

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An unexpected correlation between cardinal temperatures of microbial growth highlighted by a new model

L. Rosso, J.R. Lobry, Jean-Pierre Flandrois

Journal of Theoretical Biology . 162 : 447-463

Journal article

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Actinomyces pyogenes: susceptibility of 103 clinical animal isolates to 22 antimicrobial agents

V Guérin-Faublée, Jp Flandrois, E Broye, F Tupin, Y Richard

Veterinary Research . 24 ( 3 ) : 251-259

Journal article

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