GECO Evolutionary and Computational Genomics
Bioinformatics, Phylogeny and Evolutionary Genomics Group
Segurel Laure
Chargée de recherche
CNRS
Batiment Mendel, 2ème étage. Bureau 12.025
Broad research interests : I am a CNRS researcher in population genetics, broadly interested in using genetic data to understand species evolution, more specifically to investigate how species adapt to their environment. During my PhD at the Musée de l'Homme with E Heyer and R Vitalis (UMR7206 - Paris), I worked in anthropological genetics, to decipher how various cultural features (matrimonial rules, language) shape the genetic diversity in Central Asia. I further worked on identifying selective pressures on various metabolic genes involved in adaptation to diet in herders and farmers from Central Asia. During my post-doc at UChicago with M Przeworski, I studied how recombination evolved between humans and chimpanzees, and across human populations, and I looked for signatures of balancing selection in humans and chimpanzees genomes. I also investigated what are the different determinants of neutral genetic diversity, as well as the factors influencing mutation rates. Since I got recruited at the CNRS in 2013 (UMR7206 - Paris), I continued working on human adaptation to changes in diet by studying lactase persistence using both modern and ancient DNA. In parallel, I am interested in understanding how humans and their associated microbes are co-evolving. Specifically, I developed a project in Cameroon to better understand how the human gut (and oral) microbiota evolved in response to changes in human diet, especially linked to the growing urbanisation and industrialisation of human populations. I am currently working at the LBBE (UMR5558 - Lyon) and developing projects on balancing selection (a mode of adaptation that maintains genetic diversity), to study its prevalence and underlying mechanisms both in primates and in birds, which have contrasted recombination landscapes and effective population sizes.
Publications
Display of 1 to 30 publications on 45 in total
The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations
Preprint
see the publicationThe porphyran degradation system of the human gut microbiota is complete, phylogenetically diverse and geographically structured across Asian populations
Preprint
see the publicationProposed mechanism for the selection of lactase persistence in childhood
BioEssays . 45 ( 7 )
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics . 101 ( 1 ) : 3-15
DOI: 10.1111/tan.14852
Journal article
see the publicationModelling the spatiotemporal spread of beneficial alleles using ancient genomes
Preprint
see the publicationModeling the spatiotemporal spread of beneficial alleles using ancient genomes
eLife . 11
DOI: 10.7554/eLife.73767
Journal article
see the publicationCodiversification of gut microbiota with humans
Science . 377 ( 6612 ) : 1328-1332
Journal article
see the publicationThe human gut microbiome and health inequities
Proceedings of the National Academy of Sciences of the United States of America . 118 ( 25 ) : e2017947118
Journal article
see the publicationNo evidence for female kin association, indications for extragroup paternity, and sex‐biased dispersal patterns in wild western gorillas
Ecology and Evolution . 11 ( 12 ) : 7634-7646
DOI: 10.1002/ece3.7596
Journal article
see the publicationElevated rates of horizontal gene transfer in the industrialized human microbiome
Cell . 184 ( 8 ) : 2053-2067.e18
Journal article
see the publicationChanges in the Human Gut Microbiota Associated With Colonization by Blastocystis sp. and Entamoeba spp. in Non-Industrialized Populations
Frontiers in Cellular and Infection Microbiology . 11 : 533528
Journal article
see the publicationWhy and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA
PLoS Biology . 18 ( 6 ) : e3000742
Journal article
see the publicationResponse of the human gut and saliva microbiome to urbanization in cameroon
Scientific Reports . 10 ( 1 )
Journal article
see the publicationUse of shotgun metagenomics for the identification of protozoa in the gut microbiota of healthy individuals from worldwide populations with various industrialization levels
PLoS ONE . 14 ( 2 ) : e0211139
Journal article
see the publicationClose inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy
Scientific Reports . 8 : 9397
Journal article
see the publicationGut Protozoa: Friends or Foes of the Human Gut Microbiota?
Trends in Parasitology . 33 ( 12 ) : 925-934
Journal article
see the publicationMicrobiome intestinal ancien et problématiques médicales contemporaines
Médecine/Sciences . 33 : 984-990
Other publication
see the publicationOn the Evolution of Lactase Persistence in Humans
Annual Review of Genomics and Human Genetics . 18 ( 1 ) : 297-319
Journal article
see the publicationSex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations
American Journal of Physical Anthropology . 162 ( 4 ) : 627-640
DOI: 10.1002/ajpa.23151
Journal article
see the publicationLatitude as a co-driver of human gut microbial diversity?
BioEssays . 39 ( 3 ) : 1600145
Journal article
see the publicationDetection and interpretation of shared genetic influences on 42 human traits
Nature Genetics . 48 ( 7 ) : 709-717
DOI: 10.1038/ng.3570
Journal article
see the publicationDetection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection
Genome Biology and Evolution . 8 ( 5 ) : 1489-1500
DOI: 10.1093/gbe/evw090
Journal article
see the publicationVariation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence
PLoS Genetics . 11 ( 11 ) : e1005658
Journal article
see the publicationHuman genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming
European Journal of Human Genetics . 22 ( 10 ) : 1201-1207
Journal article
see the publicationPreserving immune diversity through ancient inheritance and admixture
Current Opinion in Immunology . 30 : 79-84
Journal article
see the publicationDeterminants of Mutation Rate Variation in the Human Germline
Annual Review of Genomics and Human Genetics . 15 ( 1 ) : 47-70
Journal article
see the publicationTroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception
Bioinformatics . 30 ( 14 ) : 2035-2042
Journal article
see the publicationMicrosatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia
European Journal of Human Genetics . 22 ( 10 ) : 1201-1207
DOI: 10.1038/ejhg.2014.2
Journal article
see the publicationHuman Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming
Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644
Journal article
see the publication