GECO Evolutionary and Computational Genomics
Bioinformatics, Phylogeny and Evolutionary Genomics Group
Coluzzi Charles
Enseignant-chercheur CPJ
UCBL
Je m’intéresse à l’évolution microbienne. Plus particulièrement, j’étudie l’évolution des éléments génétiques mobiles (plasmides, ICE et IME) et leur impact sur la résistance aux antibiotiques ainsi que sur la dynamique des transferts horizontaux de gènes entre bactéries. J’utilise des approches de génomique comparative, de bioinformatique et de phylogénétique. Je suis impliqué dans la vulgarisation scientifique auprès du grand public, notamment en visitant des écoles primaires pour éveiller les enfants au monde des microbes.
I am interested in microbial evolution. More specifically, I study the evolution of mobile genetic elements (plasmids, ICEs, IMEs) and their impact on antibiotic resistance as well as on the dynamics of horizontal gene transfer between bacteria. I use comparative genomics, bioinformatics, and phylogenetic approaches. I am involved in science outreach with the general public, especially by visiting primary schools to introduce children to the world of microbes.
Publications
Display of 1 to 25 publications on 25 in total
A type IVB secretion system contributes to the pathogenicity of Yersinia pseudotuberculosis strains responsible for the Far East scarlet-like fever
Preprint
see the publicationEvo‐Scope : Fully automated assessment of correlated evolution on phylogenetic trees
Methods in Ecology and Evolution . 15 ( 2 ) : 282 - 289
Journal article
see the publicationHijackers, hitchhikers, or co-drivers? The mysteries of mobilizable genetic elements
PLoS Biology . 22 ( 8 ) : e3002796
Journal article
see the publicationMacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes
Peer Community Journal . 3 : e28
Journal article
see the publicationChance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes
Molecular Biology and Evolution . 40 ( 10 ) : msad217
Journal article
see the publicationMacSyFinder v2: An improved search engine to model and identify molecular systems in genomes
JOBIM .
Poster
see the publicationIntracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium
PLoS Pathogens . 18 ( 4 ) : 35 p.
Journal article
see the publicationICEscreen: a valuable tool for automatic detection of ICEs and IMEs in Firmicutes
Réunion du GDR3546 Eléments transposables .
Conference paper
see the publicationICEscreen: a tool to detect Firmicute ICEs and IMEs, isolated or enclosed in composite structures
NAR Genomics and Bioinformatics . 4 ( 4 ) : lqac079
Journal article
see the publicationNAR Breakthrough Article Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation
Nucleic Acids Research . 51 ( 7 ) : 3001–3016
DOI: 10.1093/nar/gkac1079
Journal article
see the publicationStreptococcus suis as a reservoir of antibiotic resistance genes carried by Mobile Genetic Elements transferring by conjugation
5th International Caparica Congress in Antibiotic Resistance (IC2AR 2022) .
Conference paper
see the publicationEvolution of Plasmid Mobility: Origin and Fate of Conjugative and Nonconjugative Plasmids
Molecular Biology and Evolution . 39 ( 6 ) : msac115
Journal article
see the publicationChromosomal Conjugative and Mobilizable Elements in Streptococcus suis: Major Actors in the Spreading of Antimicrobial Resistance and Bacteriocin Synthesis Genes
Pathogens . 9 ( 1 ) : 22
Journal article
see the publicationKey role of chromosomal mobile genetic elements transferring by conjugation in the dissemination of antimicrobial resistance in Streptococcus suis
8th symposium on Antimicrobial Resistance in Animal and Environment .
Conference paper
see the publicationThe ICE/IME Finder approach and its application to ICE/IME annotation in Streptococcus.
8th symposium on Antimicrobial Resistance in Animal and Environment .
Conference paper
see the publicationThe ICE/IME Finder approach and its application to ICE/IME annotation in Streptococcus
4th International Workshop on Streptococcus suis .
Poster
see the publicationKey role of chromosomal mobile genetic elements transferred by conjugation in the dissemination of antimicrobial resistance in S. suis
4th International Workshop on Streptococcus suis .
Conference paper
see the publicationIntegrative Mobilizable Element (IMEs): a reservoir of antibiotic resistance genes in the zoonotic pathogen Streptococcus suis
GDR 3546 - Les elements mobiles du mécanisme aux populations, une approche intégrative .
Conference paper
see the publicationL'exploration des génomes par l'outil ICEFinder révèle la forte prévalence et l'extrême diversité des ICE et des IME de streptocoques
Thesis
see the publicationA Glimpse into the World of Integrative and Mobilizable Elements in Streptococci Reveals an Unexpected Diversity and Novel Families of Mobilization Proteins
Frontiers in Microbiology . 8 : 16
Journal article
see the publicationThe obscure world of integrative and mobilizable elements
Genes . 8 ( 11 ) : 337
DOI: 10.3390/genes8110337
Journal article
see the publicationNew Insights into the Classification and Integration Specificity of Streptococcus Integrative Conjugative Elements through Extensive Genome Exploration
Frontiers in Microbiology . 6 ( 6 ) : 1483
Journal article
see the publicationA glimpse into an unexplored world: very high diversity of integrative and mobilizable elements in Streptococci
8th ASM conference on Streptococcal Genetics .
Poster
see the publicationPrévalence et diversité des éléments intégratifs conjugatifs et mobilisables chez les streptocoques
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