Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 691 to 720 publications on 1006 in total

Multigene Analyses of Bilaterian Animals Corroborate the Monophyly of Ecdysozoa, Lophotrochozoa and Protostomia

Herve Philippe, Nicolas Lartillot, Henner Brinkmann

Molecular Biology and Evolution . 22 ( 5 ) : 1246-1253

DOI: 10.1093/molbev/msi111

Journal article

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Phylogenomics

Hervé Philippe, Frédéric Delsuc, Henner Brinkmann, Nicolas Lartillot

Annual Review of Ecology, Evolution, and Systematics . 36 : 541-562

Journal article

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Evolutionary origins of genomic repertoires in bacteria

E. Lerat, Vincent Daubin, H. Ochman, N.A. Moran

PLoS Biology . 3 : 0807-0814

Journal article

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Recognizing the pseudogenes in bacterial genomes

E. Lerat, H. Ochman

Nucleic Acids Research . 33 : 3125-3132

Journal article

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Polymorphix: a sequence polymorphism database

E. Bazin, L. Duret, Simon Penel, N. Galtier

Nucleic Acids Research . 33 : 481-484

Journal article

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Les trésors cachés du génome humain

L. Duret

Pour la science . -- : 16-21

Journal article

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Bioinformatics with a French accent

L.D. Hurst, L. Duret

Genome Biology . 6 : 349.1-349.3

Journal article

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Natural history of the ERVWE 1 endogenous retroviral locus.

Bertrand Bonnaud, Jean Beliaeff, Olivier Bouton, Guy Oriol, Laurent Duret, François Mallet

Retrovirology . 2:57 : 1 - 7

DOI: 10.1186/1742-4692-2-57

Journal article

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Online synonymous codon usage analyses with the ade4 and seqinR packages

D. Charif, J. Thioulouse, J.R. Lobry, G. Perrière

Bioinformatics . 21 : 545-547

Journal article

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MADE4: an R package for multivariate analysis of gene expression data

A.C. Culhane, J. Thioulouse, G. Perrière, D.G. Higgins

Bioinformatics . 21 : 2789-2790

Journal article

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Horizontal transfer of two operons coding for hydrogenases between bacteria and archaea.

A. Calteau, Manolo Gouy, G. Perrière

Journal of Molecular Evolution . 60 ( 5 ) : 557-65

DOI: 10.1007/s00239-004-0094-8

Journal article

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Optimized between-group classification: a new jackknife-based gene selection procedure for genome-wide expression data

F. Baty, M.P. Bihl, G. Perrière, A.C. Culhane, M.H. Brutsche

BMC Bioinformatics . 6 : 1-12

Journal article

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Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer

Aurélien Ginolhac, Cyrille Jarrin, Patrick Robe, Guy Perrière, Timothy M. Vogel, Pascal Simonet...

Journal of Molecular Evolution . ( 60 ) : 716-725

DOI: 10.1007/s00239-004-0161-1

Journal article

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In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant

A. Aouacheria, V. Navratil, W. Wen, M. Jiang, Dominique Mouchiroud, Christian Gautier...

Oncogene . 24 : 6133-6142

DOI: 10.1038/sj.onc.1208745

Journal article

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Molecular phylogeny of Myricaceae: a reexamination of host-symbiont specificity

V. Huguet, Manolo Gouy, P. Normand, J.F. Zimpfer, M.P. Fernandez

Molecular Phylogenetics and Evolution . 34 ( 3 ) : 557-568

DOI: 10.1016/j.ympev.2004.11.018

Journal article

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Phylogeography and taxonomic status of Niphargus virei (subterranean amphipod).

T. Lefébure, Christophe Jean Douady, M. Gouy, P. Trontelj, J. Briolay, Janine Gibert

Proceedings on Symposium on World Subterranean Biodiversity . : 73-74

Conference paper

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Clinical and environmental isolates of Legionella pneumophila serogroup 1 cannot be distinguished by sequence analysis of two surface protein genes and three housekeeping genes

H. Aurell, Pierre Farge, H. Meugnier, Manolo Gouy, F. Forey, G. Lina...

Applied and Environmental Microbiology . 71 : 282-289

DOI: 10.1128/AEM.71.1.282-289.2005

Journal article

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De la prévalence aux valeurs prédictives: L`antibiogramme face à l`évolution de la résistance aux antibiotiques

B. Lamy, G. Carret, Jean-Pierre Flandrois, Marie Laure Delignette-Muller

Annales de Biologie Clinique . 63 : 493-502

Journal article

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Site Interdependence Attributed to Tertiary Structure in Amino Acid Sequence Evolution

N. Rodrigue, Nicolas Lartillot, D. Bryant, H. Philippe

Gene . 347 ( 2 ) : 207-217

DOI: 10.1016/j.gene.2004.12.011

Journal article

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A bunch of fun-guys: the whole-genome view of yeast evolution

H. Ochman, Vincent Daubin, E. Lerat

Trends in Genetics . 21 : 1-3

Journal article

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Examining bacterial species under the specter of gene transfer and exchange

H. Ochman, E. Lerat, Vincent Daubin

Proceedings of the National Academy of Sciences of the United States of America . 102 : 6595-6599

Journal article

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Quantitative prediction for two-dimensional bacterial genomic displays

Jean-François Mercier, Gary W. Slater, Bénédicte Lafay

Joint 15th IUPAB and 5th EBSA International Biophysics Congress .

Conference paper

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Molecular polymorphism in Drosophila melanogaster and D. simulans: what have we learned from recent studies?

Sylvain Mousset, N. Derome

Genetica . 120 : 79-86

Journal article

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The role of natural selection in genetic differentiation of worldwide populations of Drosophila ananassae

J.F. Baines, A. Das, Sylvain Mousset, W. Stephan

Genetics . 168 : 1987-1998

Journal article

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A test of neutrality and constant population size based on the mismatch distribution

Sylvain Mousset, N. Derome, M. Veuille

Molecular Biology and Evolution . 21 : 724-731

Journal article

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Identitag, a relational database for SAGE tag identification and interspecies comparison of SAGE libraries.

Céline Keime, Francesca Damiola, Dominique Mouchiroud, Laurent Duret, Olivier Gandrillon

BMC Bioinformatics . 5 : 143

DOI: 10.1186/1471-2105-5-143

Journal article

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The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology

Frédéric Mallet, O. Bouton, S. Prudhomme, V. Cheynet, G. Oriol, B. Bonnaud...

Proceedings of the National Academy of Sciences of the United States of America . 101 : 1731-1736

Journal article

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Evidence that functional transcription units cover at least half of the human genome

M. Sémon, L. Duret

Trends in Genetics . 20 : 229-232

Journal article

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The Decline of Isochores in Mammals: An Assessment of the GC Content Variation Along the Mammalian Phylogeny

E. Belle, L. Duret, N. Galtier, A. Eyre-Walker

Journal of Molecular Evolution . 58 : 653-660

Journal article

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Identitag a relational database for SAGE tag identification and interspecies comparison of SAGE libraries

C. Keime, F. Damiola, Dominique Mouchiroud, L. Duret, Olivier Gandrillon

BMC Bioinformatics . 5 : 1-12

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