Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 391 to 420 publications on 1006 in total

Twisted Signatures of GC-Biased Gene Conversion Embedded in an Evolutionary Stable Karyotype

Carina Mugal, Peter Arndt, Hans Ellegren

Molecular Biology and Evolution . 30 ( 7 ) : 1700-1712

DOI: 10.1093/molbev/mst067

Journal article

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Human Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure L. Segurel, Raphaëlle Chaix...

Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644

DOI: 10.1093/molbev/mst156

Journal article

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Ancestry runs deeper than blood: The evolutionary history of ABO points to cryptic variation of functional importance

Laure L. Segurel, Ziyue Gao, Molly Przeworski

BioEssays . : n/a-n/a

DOI: 10.1002/bies.201300030

Journal article

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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees

E. Leffler, Z. Gao, S. Pfeifer, L. Segurel, A. Auton, O. Venn...

Science . 339 ( 6127 ) : 1578-1582

DOI: 10.1126/science.1234070

Journal article

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Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia

Laure Ségurel, Frédéric Austerlitz, Bruno Toupance, Mathieu M. Gautier, Joanna L Kelley, Patrick Pasquet...

European Journal of Human Genetics . 21 ( 10 ) : 1146-1151

DOI: 10.1038/ejhg.2012.295

Journal article

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Eloge de l'ADN poubelle

Laurent Duret, Sylvain Charlat

Pour la science . 81 : 10--17

Journal article

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Is RAD-seq suitable for phylogenetic inference? An in silico assessment and optimization

Marie Cariou, Laurent Duret, Sylvain Charlat

Ecology and Evolution . 3 ( 4 ) : 846-852

DOI: 10.1002/ece3.512

Journal article

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Génomes, protéomes et transcriptomes à foison

G. Perrière

Pour la science . 433 : 38--39

Journal article

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The molecular signal for the adaptation to cold temperature during early life on Earth

Mathieu Groussin, Bastien Boussau, Sandrine Charles, Samuel Blanquart, Manolo Gouy

Biology Letters . 9 ( 5 ) : 20130608

DOI: 10.1098/rsbl.2013.0608

Journal article

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Bioinformatique : cours et cas pratique

Gilbert Deléage, Manolo Gouy

978-2-10-058751-3

Book

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Mycobacterium bourgelatii sp. nov., a rapidly growing, non-chromogenic species isolated from the lymph nodes of cattle.

Véronique Guérin-Faublée, Jean-Pierre Flandrois, Catherine Pichat, Maria Laura Boschiroli, Brigitte Lamy

International Journal of Systematic and Evolutionary Microbiology . 63 ( Pt 12 ) : 4669-74

DOI: 10.1099/ijs.0.051979-0

Journal article

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Candida albicans and non- Candida albicans fungemia in an institutional hospital during a decade

Jean-Pierre Flandrois, Laurence Parmeland, Mathieu Gazon, Claude Guérin, Laurent Argaud, Jean-Jacques Lehot...

Medical Mycology . 51 ( 1 ) : 33-37

DOI: 10.3109/13693786.2012.686673

Journal article

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Diminution of 2,3,5-triphenyltetrazolium chloride toxicity on Listeria monocytogenes growth by iron source addition to the culture medium

T. Junillon, Jp. Flandrois

Food Microbiology . 38 : 1--5

DOI: 10.1016/j.fm.2013.07.005

Journal article

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Mesotoga infera sp. nov., a mesophilic member of the order Thermotogales, isolated from an underground gas storage aquifer.

Wajdi Ben Hania, Anne Postec, Thomas Aüllo, Anthony Ranchou-Peyruse, Gaël Erauso, Céline Brochier-Armanet...

International Journal of Systematic and Evolutionary Microbiology . 63 ( Pt 8 ) : 3003-8

DOI: 10.1099/ijs.0.047993-0

Journal article

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Metagenomics of Kamchatkan hot spring filaments reveal two new major (hyper)thermophilic lineages related to Thaumarchaeota

L. Eme, Lj. Reigstad, A. Spang, A. Lanzen, T. Weinmaier, T. Rattei...

Research in Microbiology . 164 : 425--38

DOI: 10.1016/j.resmic.2013.02.006

Journal article

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Utilization of Machine-Learning Methodologies in Order to Understand Complex Evolutionary and Functional Links among Bacterial Genomes

Olivier Poirion, Bénédicte Lafay

IFCS2013 Book of abstracts . : p. 203

Conference paper

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Tracing the origin of megaplasmids and secondary chromosomes in bacterial genomes

Olivier Poirion, Laurent Krähenbühl, Bénédicte Lafay

SBME . : A049 363

Conference paper

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Visualization and analysis of an interconnected network of genomic elements

Olivier Poirion, Bénédicte Lafay

AdO'13: Apprentissage et données Omiques - Atelier de la conférence d'apprentissage Francophone CAp'13 - PFIA 2013 8ème Plate-Forme Intelligence Artificielle . : AdO-13_paper_6

Conference paper

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Lateral Gene Transfer from the Dead.

Gergely J Szöllosi, Eric Tannier, Nicolas Lartillot, Vincent Daubin

Systematic Biology . 62 ( 3 ) : 386-397

DOI: 10.1093/sysbio/syt003

Journal article

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Reconstructing the Phylogenetic History of Long-Term Effective Population Size and Life-History Traits Using Patterns of Amino Acid Replacement in Mitochondrial Genomes of Mammals and Birds

Benoit Nabholz, Nicole Uwimana, Nicolas Lartillot

Genome Biology and Evolution . 5 ( 7 ) : 1273 - 1290

DOI: 10.1093/gbe/evt083

Journal article

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Transcriptome Characterisation of the Ant Formica exsecta with New Insights into the Evolution of Desaturase Genes in Social Hymenoptera

Hélène E Badouin, Khalid Belkhir, Emma Gregson, Juan Galindo, Liselotte Sundström, Stephen Martin...

PLoS ONE . 8 ( 7 ) : e68200

DOI: 10.1371/journal.pone.0068200

Journal article

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Genome-scale coestimation of species and gene trees.

Bastien Boussau, Gergely J Szöllosi, L. Duret, Manolo Gouy, Eric Tannier, Vincent Daubin

Genome Research . 23 ( 2 ) : 323-330

DOI: 10.1101/gr.141978.112

Journal article

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Nickel import in bacteria, structural study of extracytoplasmic nickel-binding proteins

Hugo Lebrette, Christine Cavazza, Céline Brochier-Armanet, Elise Borezée-Durant

16. International Conference on Biological Inorganic Chemistry (ICBIC) . 19 : 1

Conference paper

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XACT, a long non-coding transcript coating the active X chromosome in human pluripotent cells

Céline Vallot, Christophe Huret, Yann Lesecque, Alissa Resch, Noufϊssa Oudrhiri, Annelise Bennaceur...

Epigenetics and Chromatin: Interactions and processes . 6 ( Suppl 1 ) : O33

DOI: 10.1186/1756-8935-6-S1-O33

Conference paper

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Bio++ : Efficient Extensible Libraries and Tools for Computational Molecular Evolution

Laurent Gueguen, Sylvain Gaillard, Bastien Boussau, Manolo Gouy, Mathieu Groussin, Nicolas C. Rochette...

Molecular Biology and Evolution . 30 ( 8 ) : 1745 - 1750

DOI: 10.1093/molbev/mst097

Journal article

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Experimental assessment of the accuracy of genomic selection in sugarcane

M. Gouy, Y. Rousselle, Denis Bastianelli, Philippe Lecomte, Laurent Bonnal, D. Roques...

TAG Theoretical and Applied Genetics . 126 ( 10 ) : 2575-2586

DOI: 10.1007/s00122-013-2156-z

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Egyptian mummies record increasing aridity in the Nile valley from 5500 to 1500yr before present

Alexandra Touzeau, Janne Blichert-Toft, Romain Amiot, François Fourel, François Martineau, Jenefer Cockitt...

Earth and Planetary Science Letters . 375 : 92-100

DOI: 10.1016/j.epsl.2013.05.014

Journal article

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Phylogenies of Central Element Proteins Reveal the Dynamic Evolutionary History of the Mammalian Synaptonemal Complex: Ancient and Recent Components

J. Fraune, Céline Brochier-Armanet, M. Alsheimer, R. Benavente

GENETICS . 195 : 781--793

DOI: 10.1534/genetics.113.156679

Journal article

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LUCA, ancêtre de tous les êtres vivants

Simonetta Gribaldo, Céline Brochier-Armanet

Les Dossiers de la Recherche . 2 : 29--31

Journal article

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