Bioinformatics, Phylogeny and Evolutionary Genomics Group
Members
Maîtresse de conférences
UCBL
Tel: 04 72 44 84 87
Stagiaire
UCBL

Professeure des universités
UCBL
Tel: 33 04 26 23 44 76

Doctorante
UCBL
Enseignant-chercheur CPJ
UCBL

Directeur de recherche
CNRS
Tel: 33 04 72 44 62 97

Professeur d'université émérite
UCBL
Tel: 04 72 44 85 60
Ingénieur d'études CDD
CNRS

Directeur de recherche
CNRS
Tel: 33 04 72 43 11 67
Doctorante
UCBL

Chargée de recherche
CNRS
Tel: 33 04 72 44 85 60

Directeur de recherche
CNRS
Tel: 04 72 44 84 87
Doctorant
UCBL

Chargée de recherche
CNRS
Tel: 04 72 43 13 44

Directeur de recherche
CNRS

Professeure des universités émérite
UCBL
Tel: 04 72 44 81 42

Maître de conférences
UCBL
Tel: 04 72 43 35 83

Chargée de recherche
CNRS
Tel: 04 72 44 81 42
Doctorant
CNRS

Chargée de recherche
CNRS
Tel: 04 72 43 35 82

Directeur de recherche
CNRS
Tel: 33 04 72 44 62 96

Chargée de recherche
CNRS
Tel: 04 72 43 26 28
Doctorant
UCBL

Chercheur invité
UCBL
Ingénieur de recherche CDD
CNRS
Tel: 04 72 44 81 42
Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).
Evolution of genome architecture and expression
Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.
Phylogenomics
We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.
Teaching and outreach
We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.
Publications
Display of 391 to 420 publications on 1098 in total
Ancient west Eurasian ancestry in southern and eastern Africa
Proceedings of the National Academy of Sciences of the United States of America . 111 ( 7 ) : 2632-2637
Journal article
see the publicationUnraveling the complex maternal history of southern African Khoisan populations
American Journal of Physical Anthropology . 153 ( 3 ) : 435-448
DOI: 10.1002/ajpa.22441
Journal article
see the publicationNew insights into the history of the C-14010 lactase persistence variant in Eastern and Southern Africa
American Journal of Physical Anthropology . 156 ( 4 ) : 661-664
DOI: 10.1002/ajpa.22675
Journal article
see the publicationMigration and Interaction in a Contact Zone: mtDNA Variation among Bantu-Speakers in Southern Africa
PLoS ONE . 9 ( 6 ) : e99117
Journal article
see the publicationA high‐density linkage map enables a second‐generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution
Molecular Ecology . 23 ( 16 ) : 4035-4058
DOI: 10.1111/mec.12810
Journal article
see the publicationWhy Time Matters: Codon Evolution and the Temporal Dynamics of dN/dS
Molecular Biology and Evolution . 31 ( 1 ) : 212-231
Journal article
see the publicationPreserving immune diversity through ancient inheritance and admixture
Current Opinion in Immunology . 30 : 79-84
Journal article
see the publicationDeterminants of Mutation Rate Variation in the Human Germline
Annual Review of Genomics and Human Genetics . 15 ( 1 ) : 47-70
Journal article
see the publicationTroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception
Bioinformatics . 30 ( 14 ) : 2035-2042
Journal article
see the publicationMicrosatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia
European Journal of Human Genetics . 22 ( 10 ) : 1201-1207
DOI: 10.1038/ejhg.2014.2
Journal article
see the publicationA call for benchmarking transposable element annotation methods.
Mobile DNA . 6 : 13
Journal article
see the publicationSubcellular Localization of ENS-1/ERNI in Chick Embryonic Stem Cells
PLoS ONE . 9 ( 3 ) : e92039
Journal article
see the publicationThe spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells.
PLoS Genetics . 10 ( 5 ) : e1004282
Journal article
see the publicationThe Red Queen Model of Recombination Hotspots Evolution in the Light of Archaic and Modern Human Genomes
PLoS Genetics . 10 : e1004790
Journal article
see the publicationStrong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome
Molecular Biology and Evolution . 31 : 23-36
Journal article
see the publicationDiet of ancient Egyptians inferred from stable isotope systematics
Journal of Archaeological Science . 46 : 114-124
Journal article
see the publicationMUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.
BMC Bioinformatics . 15 ( 1 ) : 107
Journal article
see the publicationMycobacterium Species Related to M. leprae and M. lepromatosis from Cows with Bovine Nodular Thelitis
Emerging Infectious Diseases . 20 : 2111-4
Journal article
see the publicationPromiscuous Nickel Import in Human Pathogens: Structure, Thermodynamics, and Evolution of Extracytoplasmic Nickel-Binding Proteins
Structure . 22 ( 10 ) : 1421-1432
Journal article
see the publicationProtein SYCP2 Is an Ancient Component of the Metazoan Synaptonemal Complex
Cytogenetic and genome research . 144 : 299-305
DOI: 10.1159/000381080
Journal article
see the publicationPlant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family
ACS Chemical Biology . 9 ( 8 ) : 1812-1825
DOI: 10.1021/cb500278k
Journal article
see the publicationAil and PagC-Related Proteins in the Entomopathogenic Bacteria of Photorhabdus Genus
PLoS ONE . 9 ( 10 ) : e110060
Journal article
see the publicationContribution of graphs to the analysis of bacterial genome architecture
BioNetVisA workshop, ECCB'14, the 13th European Conference on Computational Biology .
Conference paper
see the publicationChromosome formation in bacteria
EMBO Conference "Microbiology after the genomics revolution : Genomes 2014" .
Conference paper
see the publicationMonte Carlo algorithms for Brownian phylogenetic models
Bioinformatics . 30 ( 21 ) : 3020-3028
Journal article
see the publicationA phylogenetic Kalman filter for ancestral trait reconstruction using molecular data
Bioinformatics . 30 ( 4 ) : 488-96
Journal article
see the publicationSite-heterogeneous mutation-selection models within the PhyloBayes-MPI package
Bioinformatics . 30 ( 7 ) : 1020-1
Journal article
see the publicationHijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae
PLoS ONE . 9 ( 6 ) : e100791
Journal article
see the publicationMicrosporidian Genomes Harbor a Diverse Array of Transposable Elements that Demonstrate an Ancestry of Horizontal Exchange with Metazoans.
Genome Biology and Evolution . 6 ( 9 ) : 2289-300
DOI: 10.1093/gbe/evu178
Journal article
see the publication