Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 451 to 480 publications on 1006 in total

Primate evolutionary history contribution to the deciphering of SIV/HIV origin and diversification

Bénédicte Lafay

Evolution Ottawa - 1th Joint Congress on Evolutionary Biology .

Conference paper

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De novo metagenomic assembly reveals abundant novel major lineage of Archaea in hypersaline microbial communities.

Priya Narasingarao, Sheila Podell, Juan A Ugalde, Céline Brochier-Armanet, Joanne B Emerson, Jochen J Brocks...

The International Society of Microbiologial Ecology Journal . 6 ( 1 ) : 81-93

DOI: 10.1038/ismej.2011.78

Journal article

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Interaction between Selection and Biased Gene Conversion in Mammalian Protein-Coding Sequence Evolution Revealed by a Phylogenetic Covariance Analysis

Nicolas Lartillot

Molecular Biology and Evolution . 30 : 356 - 368

DOI: 10.1093/molbev/mss231

Journal article

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Rapport du groupe de travail sur la gestion et le partage des données

Christine Gaspin, Dominique Pontier, Laurence Colinet, Frédéric Dardel, Alain Franc, Odile Hologne...

Report

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Rapid De Novo Evolution of X Chromosome Dosage Compensation in Silene latifolia a Plant with Young Sex Chromosomes

A. Muyle, N. Zemp, C. Deschamps, Sylvain Mousset, A. Wildmer, Gabriel Marais

PLoS Biology . 10 ( 4 ) : e1001308

DOI: 10.1371/journal.pbio.1001308

Journal article

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Lateral gene transfer as a support for the tree of life.

Sophie S Abby, Eric Tannier, Manolo Gouy, Vincent Daubin

Proceedings of the National Academy of Sciences of the United States of America . 109 ( 13 ) : 4962-4967

DOI: 10.1073/pnas.1116871109

Journal article

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High-quality sequence clustering guided by network topology and multiple alignment likelihood.

Vincent Miele, Simon Penel, Vincent Daubin, Franck Picard, Daniel Kahn, L. Duret

Bioinformatics . 28 ( 8 ) : 1078-85

DOI: 10.1093/bioinformatics/bts098

Journal article

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The evolution of gene expression levels in mammalian organs

David Brawand, Magali Soumillon, Anamaria Necsulea, Philippe Julien, Gábor Csárdi, Patrick Harrigan...

Nature . 478 ( 7369 ) : 343-348

DOI: 10.1038/nature10532

Journal article

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High-throughput sequencing of complete human mtDNA genomes from the Caucasus and West Asia: high diversity and demographic inferences.

Ivan Nasidze, Anna Schönberg, Christoph Theunert, Mingkun Li, Mark Stoneking

European Journal of Human Genetics .

DOI: 10.1038/ejhg.2011.62

Journal article

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Y-Chromosomal Variation in Sub-Saharan Africa: Insights Into the History of Niger-Congo Groups

C. de Filippo, C. Barbieri, M. Whitten, S. Mpoloka, E. Gunnarsdottir, K. Bostoen...

Molecular Biology and Evolution . 28 ( 3 ) : 1255-1269

DOI: 10.1093/molbev/msq312

Journal article

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Larger mitochondrial DNA than Y-chromosome differences between matrilocal and patrilocal groups from Sumatra

Ellen Dröfn Gunnarsdóttir, Madhusudan Nandineni, Mingkun Li, Sean Myles, David Gil, Brigitte Pakendorf...

Nature Communications . 2 : 228

DOI: 10.1038/ncomms1235

Journal article

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Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content

Carina Mugal, Hans Ellegren

Genome Biology . 12 ( 6 ) : R58

DOI: 10.1186/gb-2011-12-6-r58

Journal article

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Lactase persistence in central Asia: phenotype, genotype, and evolution.

Evelyne Heyer, Lionel Brazier, Laure Ségurel, Tatiana Hegay, Frédéric Austerlitz, Lluis Quintana-Murci...

Human Biology . 83 ( 3 ) : 379-92

DOI: 10.3378/027.083.0304

Journal article

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The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

Laure Ségurel, Ellen Miranda Leffler, Molly M. Przeworski

PLoS Biology . 9 ( 12 ) : e1001211

DOI: 10.1371/journal.pbio.1001211

Journal article

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Preventing dangerous nonsense: selection for robustness to transcriptional error in human genes.

Brian P. Cusack, Peter F. Arndt, L. Duret, Hugues Roest Crollius

PLoS Genetics . 7 ( 10 ) : e1002276

DOI: 10.1371/journal.pgen.1002276

Journal article

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Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

Corinne Chureau, Sophie Chantalat, Antonio Romito, Angélique Galvani, Laurent Duret, Philip Avner...

Human Molecular Genetics . 20 ( 4 ) : 705-718

DOI: 10.1093/hmg/ddq516

Journal article

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Meiotic recombination favors the spreading of deleterious mutations in human populations

Anamaria Necsulea, L. Duret, Alexandra Popa, David N. Cooper, Peter Stentson, Dominique Mouchiroud...

Human Mutation . 32 ( 2 ) : 198-206

DOI: 10.1002/humu.21407

Journal article

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Modélisation des systèmes biologiques, bioinformatique

Olivier Gascuel, P. Benas, C. Brun, D. Burnouf, Alexandre de Brevern, A. Denise...

Rapport de conjoncture 2010 du Comité national de la recherche scientifique . 978-2-271-07263-4 : chapitre 43, 845-858

Book chapter

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Bioinformatics developments for NGS data analysis at PRABI

F. Picard, Guy Perrière

EMBNet.journal . 17 : 12

Journal article

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Species identification of staphylococci by amplification and sequencing of the tuf gene compared to the gap gene and by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Marie Bergeron, Olivier Dauwalder, Manolo Gouy, Anne-Marie Freydiere, Michèle Bes, Hélène Meugnier...

European Journal of Clinical Microbiology and Infectious Diseases . 30 ( 3 ) : 343-54

DOI: 10.1007/s10096-010-1091-z

Journal article

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Species-driven interpretation guidelines in case of a single-sampling strategy for blood culture

D. Leyssene, S. Gardes, P. Vilquin, Jp. Flandrois, Gérard Carret, B. Lamy

European Journal of Clinical Microbiology and Infectious Diseases . 30 : 1537-1541

DOI: 10.1007/s10096-011-1257-3

Journal article

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Phylogeny and evolution of the Archaea: one hundred genomes later.

Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Current Opinion in Microbiology . : epub ahead of print

DOI: 10.1016/j.mib.2011.04.015

Journal article

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Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite.

France Denoeud, Michaël Roussel, Benjamin Noel, Ivan Wawrzyniak, Corinne da Silva, Marie Diogon...

Genome Biology . 12 ( 3 ) : R29

DOI: 10.1186/gb-2011-12-3-r29

Journal article

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Cultivation of the first mesophilic representative ("mesotoga") within the order Thermotogales

Wajdi Ben Hania, Ramzi Ghodbane, Anne Postec, Celine Brochier-Armanet, Moktar Hamdi, Marie Laure Fardeau...

Systematic and Applied Microbiology . 34 : 581-585

DOI: 10.1016/j.syapm.2011.04.001

Journal article

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The GTPase Function of YvcJ and Its Subcellular Relocalization Are Dependent on Growth Conditions in Bacillus subtilis

F. Pompeo, J. Luciano, Céline Brochier-Armanet, A. Galinier

Journal of Molecular Microbiology and Biotechnology . 20 : 156-67

Journal article

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Survival of extremely and moderately halophilic isolates of Tunisian solar salterns after UV-B or oxidative stress

H. Trigui, Salma Masmoudi, Céline Brochier-Armanet, S. Maalej, S. Dukan

Canadian Journal of Microbiology . 57(11) : 923-33

Journal article

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The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes

L. Eme, A. Trilles, D. Moreira, Céline Brochier-Armanet

BMC Evolutionary Biology . 11 : 923-33

DOI: 10.1186/1471-2148-11-265

Journal article

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The Assembly Mode of the Pseudopilus: a hallmark to distinguish a novel secretion system subtype

E. Durand, S. Alphonse, Céline Brochier-Armanet, G. Ball, Badreddine Douzi, A. Filloux...

Journal of Biological Chemistry . 286 ( 27 ) : 24407-24416

DOI: 10.1074/jbc.M111.234278

Journal article

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Taxonomie et phylogénie des procaryotes. Chapitre 6

Pierre Caumette, Céline Brochier-Armanet, Philippe Normand

Ecologie Microbienne : Microbiologie des milieux naturels et anthropisés . 2-35311-022-3 9782353110223 : 1004 p.

Book chapter

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