Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 31 to 60 publications on 1005 in total

LncRNA analyses reveal increased levels of non-coding centromeric transcripts in hepatocellular carcinoma

Anamaria Necsulea, Philippe Veber, Tuyana Boldanova, Charlotte K Y Ng, Stefan Wieland, Markus H Heim

DOI: 10.1101/2021.03.03.433778

Preprint

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Persistent homology reveals strong phylogenetic signal in 3D protein structures

Léa Bou Dagher, Dominique Madern, Philippe Malbos, Céline Brochier-Armanet

PNAS Nexus . 3 ( 4 ) : 158

DOI: 10.1093/pnasnexus/pgae158

Journal article

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The genetic legacy of the expansion of Bantu-speaking peoples in Africa

Cesar A Fortes-Lima, Concetta Burgarella, Rickard Hammarén, Anders Eriksson, Mário Vicente, Cecile Jolly...

Nature . 625 ( 7995 ) : 540–547

DOI: 10.1038/s41586-023-06770-6

Journal article

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PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids

Marie Raynaud, Paola Sanna, Julien Joseph, Julie A. J. Clément, Yukiko Imai, Jean-Jacques Lareyre...

DOI: 10.1101/2024.03.06.583651

Preprint

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The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome †

Madeline Chase, Maurine Vilcot, Carina Mugal

Proceedings of the Royal Society B: Biological Sciences . 291 ( 2015 )

DOI: 10.1098/rspb.2023.2382

Journal article

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Evidence that genetic drift not adaptation drives fast‐Z and large‐Z effects in Ficedula flycatchers

Madeline Chase, Maurine Vilcot, Carina Mugal

Molecular Ecology .

DOI: 10.1111/mec.17262

Journal article

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Description of a new genus of the Pectobacteriaceae family isolated from water in coastal brackish wetlands of the French Camargue region, Prodigiosinella gen. nov., including the new species Prodigiosinella aquatilis sp. nov

Nicole Hugouvieux-Cotte-Pattat, Jean-Pierre Flandrois, Jérôme Briolay, Sylvie Reverchon, Céline Brochier-Armanet

Systematic and Applied Microbiology . 47 ( 2-3 ) : 126497

DOI: 10.1016/j.syapm.2024.126497

Journal article

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MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation

Jérémy Tournayre, Valérie Polonais, Ivan Wawrzyniak, Reginald Florian Akossi, Nicolas Parisot, Emmanuelle Lerat...

International Journal of Molecular Sciences . 25 ( 2 ) : 880

DOI: 10.3390/ijms25020880

Journal article

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Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

Florian Bénitière, Anamaria Necsulea, Laurent Duret

eLife . 13 : RP93629

DOI: 10.7554/eLife.93629.3

Journal article

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Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes

Charles Coluzzi, Martin Guillemet, Fanny Mazzamurro, Marie Touchon, Maxime Godfroid, Guillaume Achaz...

Molecular Biology and Evolution . 40 ( 10 ) : msad217

DOI: 10.1093/molbev/msad217

Journal article

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The evolution of GC-biased gene conversion by means of natural selection

Nicolas Lartillot, Julien Joseph, Augustin Clessin

ETEE'2023: Empiricism & Theory in Ecology and Evolution .

Conference paper

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Geographic origin and social status of the Gallic warriors from Ribemont‐sur‐Ancre (France) studied through isotope systematics of bone remains

Thibault Clauzel, Pascale Richardin, Jannick Ricard, Gilles Prilaux, Jeremy Martin, Romain Amiot...

International Journal of Osteoarchaeology . 33 ( 1 ) : 39-50

DOI: 10.1002/oa.3172

Journal article

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Experimental analysis of diverse actin-like proteins from various magnetotactic bacteria by functional expression in Magnetospirillum gryphiswaldense

Ram Prasad Awal, Frank D Müller, Daniel Pfeiffer, Caroline L Monteil, Guy Perrière, Christopher T Lefèvre...

mBio . 14 ( 5 )

DOI: 10.1128/mbio.01649-23

Journal article

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A first step towards the characterization of endogenous retroviruses’ evolutionary history and impact on small ruminant genomes

Marie Verneret, Caroline Leroux, Vincent Navratil, Thomas Faraut, Emmanuelle Lerat, Jocelyn Turpin

CNET 2023 : 24th National Congress on Transposable Elements 2023 .

Conference paper

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OVINE β-ENDOGENOUS RETROVIRUSES : FROM INTEGRATION TO COPY-SPECIFIC TRANSCRIPTION

Marie Verneret, Caroline Leroux, Emmanuelle Lerat, Vincent Navratil, Jocelyn Turpin

XXVèmes Journées Francophones de Virologie .

Poster

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Mitigation of the diagenesis risk in biological apatite δ18O interpretation

Christophe Lécuyer, Jean-Pierre Flandrois

Palaeogeography, Palaeoclimatology, Palaeoecology . 630 : 111812

DOI: 10.1016/j.palaeo.2023.111812

Journal article

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δ2H and δ18O of river water from a high-altitude humid plain of the southern Alps: Implications for the interpretation of the isotopic compositions of bioapatite from humans living close to mountain areas

Christophe Lécuyer, François Atrops, François Fourel, Thibault Clauzel, Jean-Pierre Flandrois

Journal of Archaeological Science: Reports . 49 : 104020

DOI: 10.1016/j.jasrep.2023.104020

Journal article

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IFB/ELIXIR-FR, the french node of ELIXIR

Anne-Françoise Adam-Blondon, Jacques van Helden, Gildas Le Corguillé, Christophe Blanchet, Hélène Chiapello, Christine Gaspin...

ISMB ECCB 2023 .

Conference paper

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Genomic portrait and relatedness patterns of the Iron Age Log Coffin culture in northwestern Thailand

Selina Carlhoff, Wibhu Kutanan, Adam B Rohrlach, Cosimo Posth, Mark Stoneking, Kathrin Nägele...

Nature Communications . 14 ( 1 ) : 8527

DOI: 10.1038/s41467-023-44328-2

Journal article

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Genome-wide variation in the Angolan Namib Desert reveals unique pre-Bantu ancestry

Sandra Oliveira, Anne-Maria Fehn, Beatriz Amorim, Mark Stoneking, Jorge Rocha

Science Advances . 9 ( 38 )

DOI: 10.1126/sciadv.adh3822

Journal article

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South Asian maternal and paternal lineages in southern Thailand and the role of sex-biased admixture

Wipada Woravatin, Mark Stoneking, Metawee Srikummool, Jatupol Kampuansai, Leonardo Arias, Wibhu Kutanan

PLoS ONE . 18 ( 9 ) : e0291547

DOI: 10.1371/journal.pone.0291547

Journal article

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The genomic diversity of Taiwanese Austronesian groups: Implications for the “Into- and Out-of-Taiwan” models

Dang Liu, Albert Min-Shan Ko, Mark Stoneking

PNAS Nexus . 2 ( 5 )

DOI: 10.1093/pnasnexus/pgad122

Journal article

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Genomic perspectives on human dispersals during the Holocene

Mark Stoneking, Leonardo Arias, Dang Liu, Sandra Oliveira, Irina Pugach, Jae Joseph Russell B Rodriguez

Proceedings of the National Academy of Sciences of the United States of America . 120 ( 4 )

DOI: 10.1073/pnas.2209475119

Journal article

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Look4LTRs: A Long terminal repeat retrotransposon detection tool capable of cross species studies and discovering recently nested repeats

Anthony Garza, Emmanuelle Lerat, Hani Girgis

DOI: 10.1101/2023.07.28.551030

Preprint

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Phylogenomic analysis of protein‐coding genes resolves complex gall wasp relationships

Jack Hearn, Erik Gobbo, José Luis Nieves-Aldrey, Antoine Branca, James Nicholls, Georgios Koutsovoulos...

Systematic Entomology .

DOI: 10.1111/syen.12611

Journal article

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How genomics can help biodiversity conservation

Kathrin Theissinger, Carlos Fernandes, Giulio Formenti, Iliana Bista, Paul Berg, Christoph Bleidorn...

Trends in Genetics .

DOI: 10.1016/j.tig.2023.01.005

Journal article

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Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis : a model based exploration of the PRDM9 intra-genomic Red Queen

Alice Genestier, Laurent Duret, Nicolas Lartillot

PLoS Genetics . 20 ( 5 ) : e1011274

DOI: 10.1371/journal.pgen.1011274

Journal article

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Compositionally Constrained Sites Drive Long-Branch Attraction

Lénárd L Szánthó, Nicolas Lartillot, Gergely J Szöllősi, Dominik Schrempf

Systematic Biology . 72 ( 4 ) : 767 - 780

DOI: 10.1093/sysbio/syad013

Journal article

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Identifying the Best Approximating Model in Bayesian Phylogenetics: Bayes Factors, Cross-Validation or wAIC?

Nicolas Lartillot

Systematic Biology . 72 : 616 - 638

DOI: 10.1093/sysbio/syad004

Journal article

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Genes and sites under adaptation at the phylogenetic scale also exhibit adaptation at the population-genetic scale

Thibault Latrille, Nicolas Rodrigue, Nicolas Lartillot

Proceedings of the National Academy of Sciences of the United States of America . 120 ( 11 ) : e2214977120

DOI: 10.1073/pnas.2214977120

Journal article

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