Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 301 to 330 publications on 1095 in total

The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein.

J. Timm, C. Brochier-Armanet, J. Pérard, B. Zambelli, S. Ollagnier de Choudens, S. Ciurli...

Metallomics . 9 ( 5 ) : 575-583

DOI: 10.1039/c7mt00063d

Journal article

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Continental-level population differentiation and environmental adaptation in the mushroom Suillus brevipes

Sara Branco, Ke Bi, Hui-Ling Liao, Pierre Gladieux, Helene Badouin, Christopher E Ellison...

Molecular Ecology . 26 ( 7 ) : 2063-2076

DOI: 10.1111/mec.13892

Journal article

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The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

Hélène Badouin, Jerome Gouzy, Christopher Grassa, Florent Murat, S Evan Staton, Ludovic Cottret...

Nature . 546 ( 7656 ) : 148-152

DOI: 10.1038/nature22380

Journal article

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The Evolution of Sex Chromosomes and Dosage Compensation in Plants

A. Muyle, R. Shearn, Gabriel Marais

Genome Biology and Evolution . 9 : 627-645

DOI: 10.1093/gbe/evw282

Journal article

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The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

Baptiste Saudemont, Alexandra Popa, Joanna Parmley, Vincent Rocher, Corinne Blugeon, Anamaria Necsulea...

Genome Biology . 18 : 208

DOI: 10.1186/s13059-017-1344-6

Journal article

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Less effective selection leads to larger genomes

Tristan Lefébure, Claire Morvan, Florian Malard, Clémentine François, Lara Konecny-Dupré, Laurent Guéguen...

Genome Research . 27 : 1016-1028

DOI: 10.1101/gr.212589.116

Journal article

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New Insights into the Classification and Integration Specificity of Streptococcus Integrative Conjugative Elements through Extensive Genome Exploration

Chloé C. Ambroset, Charles Coluzzi, Gérard Guédon, Marie-Dominique Devignes, Valentin Loux, Thomas Lacroix...

Frontiers in Microbiology . 6 ( 6 ) : 1483

DOI: 10.3389/fmicb.2015.01483

Journal article

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A glimpse into an unexplored world: very high diversity of integrative and mobilizable elements in Streptococci

Charles Coluzzi, Gérard Guédon, Chloé Ambroset, Marie-Dominique Devignes, Sophie Payot, Nathalie N. Leblond-Bourget

8th ASM conference on Streptococcal Genetics .

Poster

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The Complex Admixture History and Recent Southern Origins of Siberian Populations

Irina Pugach, Rostislav Matveev, Viktor Spitsyn, Sergey Makarov, Innokentiy Novgorodov, Vladimir Osakovsky...

Molecular Biology and Evolution . 33 ( 7 ) : 1777-1795

DOI: 10.1093/molbev/msw055

Journal article

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Refining the Y chromosome phylogeny with southern African sequences

Chiara Barbieri, Alexander Hübner, Enrico Macholdt, Shengyu Ni, Sebastian Lippold, Roland Schröder...

Human Genetics . 135 ( 5 ) : 541 - 553

DOI: 10.1007/s00439-016-1651-0

Journal article

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A genomic history of Aboriginal Australia

Anna-Sapfo Malaspinas, Michael Westaway, Craig Muller, Vitor Hugo Sousa, Oscar Lao, Isabel Alves...

Nature . 538 ( 7624 ) : 207-214

DOI: 10.1038/nature18299

Journal article

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High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree

Linnéa Smeds, Carina Mugal, Anna Qvarnström, Hans Ellegren

PLoS Genetics . 12 ( 5 ) : e1006044

DOI: 10.1371/journal.pgen.1006044

Journal article

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Divergence in gene expression within and between two closely related flycatcher species

Severin Uebbing, Axel Künstner, Hannu Mäkinen, Niclas Backström, Paulina Bolivar, Reto Burri...

Molecular Ecology . 25 ( 9 ) : 2015-2028

DOI: 10.1111/mec.13596

Journal article

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The non-equilibrium allele frequency spectrum in a Poisson random field framework

Ingemar Kaj, Carina Mugal

Theoretical Population Biology . 111 : 51-64

DOI: 10.1016/j.tpb.2016.06.003

Journal article

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Detection and interpretation of shared genetic influences on 42 human traits

Joseph Pickrell, Tomaz Berisa, Jimmy Liu, Laure Ségurel, Joyce Tung, David A Hinds

Nature Genetics . 48 ( 7 ) : 709-717

DOI: 10.1038/ng.3570

Journal article

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Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection

Elise Lucotte, Romain Laurent, Evelyne Heyer, Laure Ségurel, Bruno Toupance

Genome Biology and Evolution . 8 ( 5 ) : 1489-1500

DOI: 10.1093/gbe/evw090

Journal article

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Oxygen isotope fractionation between bird eggshell calcite and body water: application to fossil eggs from Lanzarote (Canary Islands)

Nicolas Lazzerini, Christophe Lécuyer, Romain Amiot, Delphine Angst, Eric Buffetaut, François Fourel...

The Science of Nature Naturwissenschaften . 103 ( 9-10 )

DOI: 10.1007/s00114-016-1404-x

Journal article

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Genome-wide analysis identifies gain and loss/change of function within the small multigenic insecticidal Albumin 1 family of Medicago truncatula

L Karaki, P da Silva, F Rizk, C Chouabe, N Chantret, V Eyraud...

BMC Plant Biology . 16 ( 1 ) : 63

DOI: 10.1186/s12870-016-0745-0

Journal article

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Novel genomic island modifies DNA with 7-deazaguanine derivatives

J.J. Thiaville, S.M. Kellner, Y. Yuan, G. Hutinet, P.C. Thiaville, W. Jumpathong...

Proceedings of the National Academy of Sciences of the United States of America . 113 : e1452-e1459

Journal article

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Evolutionary history of the mammalian synaptonemal complex

J. Fraune, Céline Brochier-Armanet, M. Alsheimer, J. N. Volff, K. Schucker, R. Benavente

Chromosoma . 125 : 355-60

DOI: 10.1007/s00412-016-0583-8

Journal article

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Closing the gap between rocks and clocks using total-evidence dating

F. Ronquist, Nicolas Lartillot, M.J. Phillips

Philosophical Transactions of the Royal Society B: Biological Sciences . 371 : 20150136

DOI: 10.1098/rstb.2015.0136

Journal article

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Lower prevalence but similar fitness in a parasitic fungus at higher radiation levels near Chernobyl

Gabriela G. Aguileta, Helene Badouin, Michael E Hood, Anders Pape Møller, Stephanie Le Prieur, Alodie Snirc...

Molecular Ecology . 25 ( 14 ) : 3370-83

DOI: 10.1111/mec.13675

Journal article

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The changing view of eukaryogenesis - fossils, cells, lineages and how they all come together

J. B. Dacks, M. C. Field, R. Buick, L. Eme, Simonetta Gribaldo, A. J. Roger...

Journal of Cell Science . 129 ( 20 ) : 3695-3703

DOI: 10.1242/jcs.178566

Journal article

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A mixed relaxed clock model

Nicolas Lartillot, M. J. Phillips, F. Ronquist

Philosophical Transactions of the Royal Society B: Biological Sciences . 371 : 20150132

DOI: 10.1098/rstb.2015.0132

Journal article

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Polymorphic Microsatellite Markers for the Tetrapolar Anther-Smut Fungus Microbotryum saponariae Based on Genome Sequencing

Taiadjana M. Fortuna, Alodie Snirc, Hélène Badouin, Jerome Gouzy, Sophie Siguenza, Diane Esquerre...

PLoS ONE . 11 ( 11 ) : e0165656

DOI: 10.1371/journal.pone.0165656

Journal article

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Qualité des données NGS : de la séquence aux bases de données

Pierre Peyret, Julie Aubert, Vincent Breton, François Enault, Line Le Gall, Denis Le Paslier...

La génomique environnementale . 978-1-78405-151-8 : 180 p.

Book chapter

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