Evaluation and Modeling with the Therapeutic Effects Group
Members
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Post-doc
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 241 to 270 publications on 613 in total
Erratum à l’article : « Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie (Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review) [Presse Med. 2019;48:563–581]
La Presse Médicale . 48 ( 11 ) : 1360
Journal article
see the publicationParameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study
Journal of Antimicrobial Chemotherapy . 74 ( 9 ) : 2676-2680
DOI: 10.1093/jac/dkz248
Journal article
see the publication[Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review].
La Presse Médicale . 48 ( 5 ) : 563-567
Journal article
see the publicationGoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial
Trials . 20 ( 1 ) : 699
Journal article
see the publicationMinoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial
BMC Pediatrics . 19 ( 1 ) : 170
Journal article
see the publicationPostsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study
Archives de Pédiatrie . 26 : 145 - 150
Journal article
see the publicationChallenges in personalized evidence-based medicine, applications in type 2 diabetes
Thesis
see the publicationUsefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis
Pediatric Pulmonology . 55 ( 1 ) : 136-140
DOI: 10.1002/ppul.24546
Journal article
see the publicationHealth-related quality of life in children interstitial lung disease.
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationHealth‐related quality of life in infants and children with interstitial lung disease
Pediatric Pulmonology . 54 ( 6 ) : 828-836
DOI: 10.1002/ppul.24308
Journal article
see the publicationViral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study
Virology Journal . 16 ( 1 ) : 111
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationComparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect
Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64
DOI: 10.1111/bcpt.13293
Journal article
see the publicationComparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect
Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64
DOI: 10.1111/bcpt.13293
Journal article
see the publicationThe contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
Journal article
see the publicationAmikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients
Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19
DOI: 10.1128/AAC.00993-19
Journal article
see the publicationPharmacokinetic variability of beta-lactams in critically ill patients: A narrative review
Anaesthesia Critical Care & Pain Medicine .
Journal article
see the publicationDo patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Journal article
see the publicationThe limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Journal article
see the publicationApport de la génomique dans la médecine de demain, applications cliniques et enjeux
Thérapie . 74 ( 1 ) : 1-8
Journal article
see the publicationImmune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Book chapter
see the publicationDo non-steroidal anti-inflammatory drugs improve sport performance ? A meta-analysis of randomized trials Introduction
23e Congrès de la Société Française de Pharmacologie et de Thérapeutique (SFPT 2019) .
Poster
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationClomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies
BJOG: An International Journal of Obstetrics and Gynaecology .
Journal article
see the publicationRisk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.
Rheumatology . 57 : 1432–1438
Journal article
see the publicationA Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4
Clinical Pharmacokinetics . 58 ( 4 ) : 503-523
Journal article
see the publicationComment on: MIC-based dose adjustment: facts and fables
Journal of Antimicrobial Chemotherapy . 73 ( 9 ) : 2584-2585
DOI: 10.1093/jac/dky131
Journal article
see the publicationPopulation Pharmacokinetic Study of Amoxicillin-Treated Burn Patients Hospitalized at a Swiss Tertiary-Care Center
Antimicrobial Agents and Chemotherapy . 62 ( 9 )
DOI: 10.1128/AAC.00505-18
Journal article
see the publication
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