Evaluation and Modeling with the Therapeutic Effects Group
Members

Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87

Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18

Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83

Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99

Praticienne hospitalière
HCL

Praticien hospitalier
HCL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier émérite
UCBL

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01

Post-doc
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Doctorante
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Doctorante
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 241 to 270 publications on 642 in total
Preoperative Topical Estrogen Treatment vs Placebo in 244 Children With Midshaft and Posterior Hypospadias
Journal of Clinical Endocrinology and Metabolism . 105 ( 7 ) : 2422-2429
Journal article
see the publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of Physical and Rehabilitation Medicine . 63 ( 3 ) : 230-240
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Journal article
see the publicationSyndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?
36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194
Conference paper
see the publicationCollaboration between academics, small pharmaceutical company and patient organizations in the development of a new formulation of cysteamine in nephropathic cystinosis: A successful story
Thérapie . 75 ( 2 ) : 169--173
Journal article
see the publicationAcute renal and splenic infarctions: a review
QJM: An International Journal of Medicine .
DOI: 10.1093/qjmed/hcz252
Journal article
see the publicationExtra-respiratory comorbidities and transplantation in the French cystic fibrosis registry
Expert Review of Respiratory Medicine . 13 ( 8 ) : 799-802
Journal article
see the publicationCystic fibrosis-related diabetes before lung transplantation is associated with lower survival but does not affect long-term renal function
Pediatric Pulmonology . 54 ( 7 ) : 977-983
DOI: 10.1002/ppul.24307
Journal article
see the publicationImpact of prone positioning in infants with Pierre Robin sequence: a polysomnography study
Sleep Medicine . 54 : 257 - 261
Journal article
see the publicationDiaphragmatic paralysis in young children: A literature review
Pediatric Pulmonology . 54 ( 9 ) : 1367-1373
DOI: 10.1002/ppul.24383
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 ) : 102361
Journal article
see the publicationDo patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis . 18 ( 4 ) : 461 - 467
Journal article
see the publicationOff-label drug prescriptions in French general practice: a cross-sectional study
BMJ Open . 9 ( 4 ) : e026076
Journal article
see the publicationA capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France
Thérapie . 74 : 645 - 650
Journal article
see the publicationThe French Pregnancy Cohort: Medication use during pregnancy in the French population
PLoS ONE . 14 ( 7 ) : e0219095
Journal article
see the publicationAdverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers
Joint Bone Spine . 86 ( 3 ) : 351-355
Journal article
see the publicationOff-label drug prescriptions in French general practice: a cross-sectional study
BMJ Open . 9 ( 4 ) : e026076
Journal article
see the publicationAssociation between difference in blood pressure reduction and risk of cardiovascular events in a type 2 diabetes population: A meta-regression analysis
Diabetes Metab .
Journal article
see the publicationGLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis
PLoS ONE . 14 ( 6 ) : e0217701
Journal article
see the publicationINN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice
European Journal of Clinical Pharmacology . 75 ( 2 ) : 275-283
Journal article
see the publicationSafety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database
Joint Bone Spine . 86 ( 3 ) : 343-350
Journal article
see the publicationQuantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8
Clinical Pharmacokinetics . 59 ( 6 ) : 757-770
Journal article
see the publicationErratum à l’article : « Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie (Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review) [Presse Med. 2019;48:563–581]
La Presse Médicale . 48 ( 11 ) : 1360
Journal article
see the publicationParameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study
Journal of Antimicrobial Chemotherapy . 74 ( 9 ) : 2676-2680
DOI: 10.1093/jac/dkz248
Journal article
see the publication[Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review].
La Presse Médicale . 48 ( 5 ) : 563-567
Journal article
see the publicationGoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial
Trials . 20 ( 1 ) : 699
Journal article
see the publication
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