Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 241 to 270 publications on 628 in total

Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis . 18 ( 4 ) : 461 - 467

DOI: 10.1016/j.jcf.2019.02.003

Journal article

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Off-label drug prescriptions in French general practice: a cross-sectional study

François Drogou, Allison Netboute, Joris Giai, Xavier Dode, David Darmon, Behrouz Kassai...

BMJ Open . 9 ( 4 ) : e026076

DOI: 10.1136/bmjopen-2018-026076

Journal article

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A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France

Marine Auffret, Benjamin Rolland, Hélène Béhal, Julien Labreuche, Emilie Jouanjus, Régis Bordet...

Thérapie . 74 : 645 - 650

DOI: 10.1016/j.therap.2019.06.002

Journal article

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The French Pregnancy Cohort: Medication use during pregnancy in the French population

Anick Bérard, Fatima Abbas-Chorfa, Behrouz Kassai, Thierry Vial, Kim Nguyen, Odile Sheehy...

PLoS ONE . 14 ( 7 ) : e0219095

DOI: 10.1371/journal.pone.0219095

Journal article

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Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers

Thierry Vial, Anne Marie Patat, David Boels, Delphine Castellan, Antoine Villa, Hélène Théophile...

Joint Bone Spine . 86 ( 3 ) : 351-355

DOI: 10.1016/j.jbspin.2018.09.006

Journal article

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Off-label drug prescriptions in French general practice: a cross-sectional study

François Drogou, Allison Netboute, Joris Giai, Xavier Dode, David Darmon, Behrouz Kassai...

BMJ Open . 9 ( 4 ) : e026076

DOI: 10.1136/bmjopen-2018-026076

Journal article

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Association between difference in blood pressure reduction and risk of cardiovascular events in a type 2 diabetes population: A meta-regression analysis

G. Grenet, H. H. Le, T. Bejan-Angoulvant, S. Erpeldinger, R. Boussageon, B. Kassai...

Diabetes Metab .

DOI: 10.1016/j.diabet.2019.05.003

Journal article

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GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis

G. Grenet, S. Ribault, G. B. Nguyen, F. Glais, A. Metge, T. Linet...

PLoS ONE . 14 ( 6 ) : e0217701

DOI: 10.1371/journal.pone.0217701

Journal article

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INN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice

Florent De Bruyne, Arnaud Ponçon, Joris Giai, Xavier Dode, Cyrille Colin, François Gueyffier...

European Journal of Clinical Pharmacology . 75 ( 2 ) : 275-283

DOI: 10.1007/s00228-018-2580-8

Journal article

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Extended Anticoagulation for VTE

Vicky Mai, Charles-Antoine Guay, Laurie Perreault, Sébastien Bonnet, Laurent Bertoletti, Yves Lacasse...

Chest . 155 ( 6 ) : 1199-1216

DOI: 10.1016/j.chest.2019.02.402

Journal article

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Safety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database

Natalia Cabrera, Jean-Christophe Lega, Behrouz Kassai, Carine Wouters, Anuela Kondi, Elvira Cannizzaro...

Joint Bone Spine . 86 ( 3 ) : 343-350

DOI: 10.1016/j.jbspin.2018.08.003

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/s0140-6736(19)31675-7

Journal article

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Quantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8

Michel Tod, Laurent Bourguignon, Nathalie Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 59 ( 6 ) : 757-770

DOI: 10.1007/s40262-019-00853-2

Journal article

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Erratum à l’article : « Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie (Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review) [Presse Med. 2019;48:563–581]

Anne-Margaux Belat, Audrey Haquin, Marc O'Brien, Sylvain Goutelle, Blandine de la Gastine, Marc O’brien

La Presse Médicale . 48 ( 11 ) : 1360

DOI: 10.1016/j.lpm.2019.11.003

Journal article

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[Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review].

Anne-Margaux Belat, Audrey Haquin, Marc O'Brien, Sylvain Goutelle, Blandine de la Gastine, Marc O’brien

La Presse Médicale . 48 ( 5 ) : 563-567

DOI: 10.1016/j.lpm.2019.04.007

Journal article

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Parameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study

Nicolas Benech, Oana Dumitrescu, Oana Dumitrescu, Anne Conrad, Anne Conrad, Marie Balsat...

Journal of Antimicrobial Chemotherapy . 74 ( 9 ) : 2676-2680

DOI: 10.1093/jac/dkz248

Journal article

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GoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial

Valentin Garyga, Florian Pochelu, Béatrice Thivichon-Prince, Walid Aouini, Julie Santamaria, France Lambert...

Trials . 20 ( 1 ) : 699

DOI: 10.1186/s13063-019-3738-0

Journal article

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Minoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial

Behrouz Kassai, Philippe Bouyé, Brigitte Gilbert-Dussardier, François Godart, Jean-Benoit Thambo, Massimiliano Rossi...

BMC Pediatrics . 19 ( 1 ) : 170

DOI: 10.1186/s12887-019-1544-1

Journal article

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Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study

A. Benahmed-Canat, F. Plaisant, B. Riche, M. Rabilloud, G. Canat, N. Paret...

Archives de Pédiatrie . 26 : 145 - 150

DOI: 10.1016/j.arcped.2019.02.011

Journal article

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Challenges in personalized evidence-based medicine, applications in type 2 diabetes

Guillaume Grenet

Thesis

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Usefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis

Stéphanie Wanin, Clara Malka-Ruimy, Antoine Deschildre, Nadia Nathan, Gabriel Reboux, Philippe Reix...

Pediatric Pulmonology . 55 ( 1 ) : 136-140

DOI: 10.1002/ppul.24546

Journal article

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Health-related quality of life in children interstitial lung disease.

Nadia Nathan, Clara Lauby, Rola Abou Taam, Katia Bessaci, Jacques Brouard, Marie-Laure Dalphin...

European Respiratory Society (ERS) Congress .

Conference paper

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Health‐related quality of life in infants and children with interstitial lung disease

Clara Lauby, Pierre-Yves Boëlle, Rola Abou Taam, Katia Bessaci, Jacques Brouard, Marie‐laure Dalphin...

Pediatric Pulmonology . 54 ( 6 ) : 828-836

DOI: 10.1002/ppul.24308

Journal article

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Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study

Mathilde Eymery, Florence Morfin, Anne Doleans-Jordheim, Marie Perceval, Camille Ohlmann, Catherine Mainguy...

Virology Journal . 16 ( 1 ) : 111

DOI: 10.1186/s12985-019-1208-7

Journal article

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Survival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature

M. R. Pokeerbux, J. Giovannelli, L. Dauchet, L. Mouthon, C. Agard, Jean-Christophe Lega...

Arthritis Research and Therapy . 21 ( 1 ) : 86

DOI: 10.1186/s13075-019-1867-1

Journal article

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Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 )

DOI: 10.1016/j.autrev.2019.102361

Journal article

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Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis

Thomas Barba, Romain Fort, Vincent Cottin, Steeve Provencher, Isabelle Durieu, Sabine Jardel...

Autoimmunity Reviews . 18 ( 2 ) : 113 - 122

DOI: 10.1016/j.autrev.2018.07.013

Journal article

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Comparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect

Guillaume Grenet, Corentin Blanc, Claire Bardel, François Gueyffier, Pascal Roy

Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64

DOI: 10.1111/bcpt.13293

Journal article

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Comparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect

Guillaume Grenet, Corentin Blanc, Claire Bardel, François Gueyffier, Pascal Roy

Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64

DOI: 10.1111/bcpt.13293

Journal article

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The contribution of genomics in the medicine of tomorrow, clinical applications and issues

Bruno Laviolle, Patrice Denèfle, François Gueyffier, Élodie Bégué, Pascal Bilbault, Helene Esperou...

Thérapie . 74 ( 1 ) : 9-15

DOI: 10.1016/j.therap.2018.11.012

Journal article

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