Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Stagiaire
HCL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Maîtresse de conférences - praticienne hospitalière
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 181 to 210 publications on 256 in total
Individual patient data meta-analysis of survival data using Poisson regression models.
BMC Medical Research Methodology . 12 ( 1 ) : 34
Journal article
see the publicationComparison of Four Renal Function Estimation Equations for Pharmacokinetic Modeling of Gentamicin in Geriatric Patients
Antimicrobial Agents and Chemotherapy . 56 ( 4 ) : 1862-1869
DOI: 10.1128/AAC.05634-11
Journal article
see the publicationReappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.
PLoS Medicine . 9 ( 4 ) : e1001204
Journal article
see the publicationApport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique
Thérapie . 67 : 359--66
Journal article
see the publicationContribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions
Thérapie . 67 : 367--74
Journal article
see the publicationVirtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology
PLoS Computational Biology . 8 : e1002571
Journal article
see the publicationEfficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study
Journal of Nutrition, Health & Aging . 16 : 370--377
Journal article
see the publicationImpact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.
Trials . 13 ( 1 ) : 231
Journal article
see the publicationEvaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations
Journal of Antimicrobial Chemotherapy . 67 : 2207--2212
DOI: 10.1093/jac/dks195
Journal article
see the publicationRelationship between benzodiazepines use and falls in the elderly: A multicenter study in three geriatric centers of a university hospital
Annales Pharmaceutiques Françaises . 70 : 46-52
Journal article
see the publicationPrescriptions analysis by clinical pharmacists in the post-operative period: a 4-year prospective study.
Acta Anaesthesiologica Scandinavica . 56 ( 8 ) : 1047-51
Journal article
see the publicationA New Animal Model of Obstructive Sleep Apnea Responding to Continuous Positive Airway Pressure
SLEEP . 34 : 541-548
Journal article
see the publicationIntrafamilial transmission of Staphylococcus aureus Panton-Valentine leukocidin responsible for two cases of neonatal necrotizing pneumonia
Archives de Pédiatrie . 18 : 1090-1094
Journal article
see the publicationCombined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation
Thorax . 66 ( 10 ) : 918-9
Journal article
see the publicationProgrammed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients
Critical Care . 15 ( 2 ) : R99
DOI: 10.1186/cc10112
Journal article
see the publicationEffect of intensive glucose lowering treatment on all cause mortality cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
British medical journal . 343 : 1-12
DOI: 10.1136/bmj.d4169
Journal article
see the publicationProgrammed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.
Critical Care . 15 ( 2 ) : R99
DOI: 10.1186/cc10112
Journal article
see the publicationThe Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies
PLoS ONE . 6 ( 3 ) : 1-7
Journal article
see the publicationProbable Drug Interaction Between Intravenous Ciprofloxacin and Mycophenolate Mofetil in a Bone Marrow Transplant Recipient
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy . 31(1) : 36-40
Journal article
see the publicationTowards personalized medicine: exploring the consequences of the effect model-based approach
Personalized Medicine . 8 : 581-586
DOI: 10.2217/pme.11.54
Journal article
see the publicationProblématique des cibles de pression artérielle
Revue médicale Suisse . : 873
Journal article
see the publicationl-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial.
British Journal of Haematology . 153 ( 1 ) : 58-65
Journal article
see the publicationStandard requirements for GCP-compliant data management in multinational clinical trials
Trials . 12 : 85
Journal article
see the publicationBlood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets
Journal of Hypertension . 29 : 171-175
Journal article
see the publicationMathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
Journal of Theoretical Biology .
Journal article
see the publicationMathematical modeling of pulmonary tuberculosis therapy: Insights from a prototype model with rifampin
Journal of Theoretical Biology . 282 ( 1 ) : 80-92
Journal article
see the publicationGenotype-Based Quantitative Prediction of Drug Exposure for Drugs Metabolized by CYP2D6
Clinical Pharmacology and Therapeutics . 90 : 582-587
Journal article
see the publicationQuantitative prediction of cytochrome P450(CYP) 2D6-Mediated drug interactions
Clinical Pharmacokinetics . 50(8) : 519-530
Journal article
see the publicationHyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function.
Radiology . 255 ( 1 ) : 225-32
Journal article
see the publicationIntrapulmonary Pharmacokinetics and Pharmacodynamics of Micafungin in Adult Lung Transplant Patients
Antimicrobial Agents and Chemotherapy . 54 ( 8 ) : 3451-3459
DOI: 10.1128/AAC.01647-09
Journal article
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