Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87

Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18

Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83

Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99

Doctorante
autre
Tel: 04 72 44 81 42

Praticien hospitalier
HCL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier émérite
UCBL

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01

Post-doc
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Doctorante
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 211 to 240 publications on 628 in total
ANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance
La Presse Médicale . 49 ( 3 ) : 104031
Journal article
see the publicationThe benefit–risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials
Rheumatology . 59 ( 9 ) : 2226-2236
Journal article
see the publicationRectal endometriosis: predictive MRI signs for segmental bowel resection
European Radiology . 31 ( 2 ) : 884-894
Journal article
see the publicationSevere infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis
Autoimmunity Reviews . 19 ( 5 ) : 102505
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research & Therapy . 22 ( 1 ) : 30
Journal article
see the publicationAnalysis of ncidence of hrombotic omplications in the resence of ompeting isks
Thrombosis Research . 191 : 152
Journal article
see the publicationOutpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections
Frontiers in Medicine . 7 : 585658
Journal article
see the publicationNonparametric Methods in Population Pharmacokinetics
Journal of Clinical Pharmacology . 62 ( 2 ) : 142-157
DOI: 10.1002/jcph.1650
Journal article
see the publicationDrug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction
Fundamental & Clinical Pharmacology . 35 ( 2 ) : 208-216
DOI: 10.1111/fcp.12601
Journal article
see the publicationAzithromycin for COVID-19: More Than Just an Antimicrobial?
Clinical Drug Investigation . 40 ( 8 ) : 683-686
Journal article
see the publicationIntra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children
Clinical Pharmacokinetics . 59 ( 8 ) : 1049-1061
Journal article
see the publicationA population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk
British Journal of Clinical Pharmacology . 86 ( 8 ) : 1642-1653
DOI: 10.1111/bcp.14278
Journal article
see the publicationAdverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates
Archives de Pédiatrie . 27 : 452 - 455
Journal article
see the publicationRole of ultrasonography in the assessment of correct endotracheal tube placement in neonates
Acta Paediatrica . 109 ( 5 ) : 1057-1059
DOI: 10.1111/apa.15097
Journal article
see the publicationClinical response to lumacaftor-ivacaftor in patients with cystic fibrosis according to baseline lung function
Journal of Cystic Fibrosis .
Journal article
see the publicationReal-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis
American Journal of Respiratory and Critical Care Medicine . 201 ( 2 ) : 188-197
Journal article
see the publicationImpact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients
Frontiers in Cellular and Infection Microbiology . 10 : 105996
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 ) : 5341
Journal article
see the publicationAssessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study
BMJ Open . 10 ( 11 ) : e041268
Journal article
see the publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Journal article
see the publicationSyndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?
36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194
Conference paper
see the publicationCollaboration between academics, small pharmaceutical company and patient organizations in the development of a new formulation of cysteamine in nephropathic cystinosis: A successful story
Thérapie . 75 ( 2 ) : 169--173
Journal article
see the publicationImpact of prone positioning in infants with Pierre Robin sequence: a polysomnography study
Sleep Medicine . 54 : 257 - 261
Journal article
see the publicationDiaphragmatic paralysis in young children: A literature review
Pediatric Pulmonology . 54 ( 9 ) : 1367-1373
DOI: 10.1002/ppul.24383
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 ) : 102361
Journal article
see the publication
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