Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 211 to 240 publications on 613 in total

Role of ultrasonography in the assessment of correct endotracheal tube placement in neonates

Claire‐sophie Descamps, Anne Beissel, Philippe Vo Van, Marine Butin, Nicolas Stacoffe, Joris Giai...

Acta Paediatrica . 109 ( 5 ) : 1057-1059

DOI: 10.1111/apa.15097

Journal article

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Efficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis

Mikail Nourredine, Lucie Jurek, Marine Auffret, Sylvain Iceta, Guillaume Grenet, Behrouz Kassai...

CNS Spectrums . 26 ( 5 ) : 459-467

DOI: 10.1017/S1092852920001613

Journal article

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Clinical response to lumacaftor-ivacaftor in patients with cystic fibrosis according to baseline lung function

Pierre-Régis Burgel, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prevotat, Marlene Murris-Espin...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2020.06.012

Journal article

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Real-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis

Pierre-Régis Burgel, Anne Munck, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prévotat...

American Journal of Respiratory and Critical Care Medicine . 201 ( 2 ) : 188-197

DOI: 10.1164/rccm.201906-1227OC

Journal article

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Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients

Paul Briaud, Sylvère Bastien, Laura Camus, Marie Boyadjian, Philippe Reix, Catherine Mainguy...

Frontiers in Cellular and Infection Microbiology . 10 : 105996

DOI: 10.3389/fcimb.2020.00266

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Behal, Luc Mouthon, Gregory Pugnet, Jean-Christophe Lega...

Arthritis Research and Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)

Benjamin Terrier, Raphaël Darbon, Cécile-Audrey Durel, Eric Hachulla, Alexandre Karras, Hélène Maillard...

Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351

DOI: 10.1186/s13023-020-01621-3

Journal article

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Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Jérôme Hadjadj, Carla Noemi Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi...

Nature Communications . 11 ( 1 ) : 5341

DOI: 10.1038/s41467-020-18925-4

Journal article

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Assessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study

S. Trouillet-Assant, C. Albert Vega, A. Bal, J. A. Nazare, P. Fascia, A. Paul...

BMJ Open . 10 ( 11 ) : e041268

DOI: 10.1136/bmjopen-2020-041268

Journal article

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Inconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis

Sébastien Mateo, Julie Di Marco, Michel Cucherat, François Gueyffier, Gilles Rode

Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240

DOI: 10.1016/j.rehab.2019.05.008

Journal article

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Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Alexandre Belot, Gillian Rice, Sulliman Ommar Omarjee, Quentin Rouchon, Eve Smith, Marion Moreews...

The Lancet Rheumatology . 2 ( 2 ) : e99-e109

DOI: 10.1016/S2665-9913(19)30142-0

Journal article

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Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials

Aurélien Hugues, Julie Di Marco, Isabelle Bonan, Gilles Rode, Michel Cucherat, François Gueyffier

PLoS ONE . 15 ( 3 ) : e0229822

DOI: 10.1371/journal.pone.0229822

Journal article

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Syndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?

Jordan Teoli, Claire Bardel, Marie Fablet, Gabriel Marais, François Gueyffier, Jean-François Lemaître...

36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194

DOI: 10.1016/j.ando.2020.07.150

Conference paper

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Collaboration between academics, small pharmaceutical company and patient organizations in the development of a new formulation of cysteamine in nephropathic cystinosis: A successful story

Ségolène Gaillard, Laurent Roche, Georges Deschênes, Denis E. J. Morin, Christine Vianey-Saban, Cécile Acquaviva-Bourdain...

Thérapie . 75 ( 2 ) : 169--173

DOI: 10.1016/j.therap.2020.02.008

Journal article

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Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 ) : 102361

DOI: 10.1016/j.autrev.2019.102361

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/S0140-6736(19)31675-7

Journal article

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Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis . 18 ( 4 ) : 461 - 467

DOI: 10.1016/j.jcf.2019.02.003

Journal article

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Off-label drug prescriptions in French general practice: a cross-sectional study

François Drogou, Allison Netboute, Joris Giai, Xavier Dode, David Darmon, Behrouz Kassai...

BMJ Open . 9 ( 4 ) : e026076

DOI: 10.1136/bmjopen-2018-026076

Journal article

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A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France

Marine Auffret, Benjamin Rolland, Hélène Béhal, Julien Labreuche, Emilie Jouanjus, Régis Bordet...

Thérapie . 74 : 645 - 650

DOI: 10.1016/j.therap.2019.06.002

Journal article

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The French Pregnancy Cohort: Medication use during pregnancy in the French population

Anick Bérard, Fatima Abbas-Chorfa, Behrouz Kassai, Thierry Vial, Kim Nguyen, Odile Sheehy...

PLoS ONE . 14 ( 7 ) : e0219095

DOI: 10.1371/journal.pone.0219095

Journal article

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Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers

Thierry Vial, Anne Marie Patat, David Boels, Delphine Castellan, Antoine Villa, Hélène Théophile...

Joint Bone Spine . 86 ( 3 ) : 351-355

DOI: 10.1016/j.jbspin.2018.09.006

Journal article

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Off-label drug prescriptions in French general practice: a cross-sectional study

François Drogou, Allison Netboute, Joris Giai, Xavier Dode, David Darmon, Behrouz Kassai...

BMJ Open . 9 ( 4 ) : e026076

DOI: 10.1136/bmjopen-2018-026076

Journal article

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Association between difference in blood pressure reduction and risk of cardiovascular events in a type 2 diabetes population: A meta-regression analysis

G. Grenet, H. H. Le, T. Bejan-Angoulvant, S. Erpeldinger, R. Boussageon, B. Kassai...

Diabetes Metab .

DOI: 10.1016/j.diabet.2019.05.003

Journal article

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GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis

G. Grenet, S. Ribault, G. B. Nguyen, F. Glais, A. Metge, T. Linet...

PLoS ONE . 14 ( 6 ) : e0217701

DOI: 10.1371/journal.pone.0217701

Journal article

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INN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice

Florent De Bruyne, Arnaud Ponçon, Joris Giai, Xavier Dode, Cyrille Colin, François Gueyffier...

European Journal of Clinical Pharmacology . 75 ( 2 ) : 275-283

DOI: 10.1007/s00228-018-2580-8

Journal article

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Extended Anticoagulation for VTE

Vicky Mai, Charles-Antoine Guay, Laurie Perreault, Sébastien Bonnet, Laurent Bertoletti, Yves Lacasse...

Chest . 155 ( 6 ) : 1199-1216

DOI: 10.1016/j.chest.2019.02.402

Journal article

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Predictive factors of renal involvement in cryoglobulinaemia: a retrospective study of 153 patients

Vladimir Coliche, Marie-Nathalie Sarda, Maurice Laville, Roland Chapurlat, Sylvain Rheims, Pascal Sève...

Clinical Kidney Journal . 12 ( 3 ) : 365-372

DOI: 10.1093/ckj/sfy096

Journal article

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Safety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database

Natalia Cabrera, Jean-Christophe Lega, Behrouz Kassai, Carine Wouters, Anuela Kondi, Elvira Cannizzaro...

Joint Bone Spine . 86 ( 3 ) : 343-350

DOI: 10.1016/j.jbspin.2018.08.003

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/s0140-6736(19)31675-7

Journal article

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Quantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8

Michel Tod, Laurent Bourguignon, Nathalie Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 59 ( 6 ) : 757-770

DOI: 10.1007/s40262-019-00853-2

Journal article

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