Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 211 to 240 publications on 654 in total

Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Romain Garreau, Romain Bricca, Marie-Claude Gagnieu, Sandrine Roux, Anne Conrad, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257

DOI: 10.1093/jac/dkab006

Journal article

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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Vianney Tuloup, Mathilde France, Romain Garreau, Nathalie Bleyzac, Laurent Bourguignon, Michel Tod...

Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321

DOI: 10.1128/AAC.01043-21

Journal article

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Expected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures

Simon Pageaud, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe...

Vaccines . 9 ( 12 ) : 1462

DOI: 10.3390/vaccines9121462

Journal article

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Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Romain Garreau, Benoît Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod...

Antibiotics . 10 ( 10 ) : 1228

DOI: 10.3390/antibiotics10101228

Journal article

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Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

Charlotte Genestet, Elisabeth Hodille, Alexia Barbry, Jean-Luc Berland, Jonathan Hoffmann, Emilie Westeel...

PLoS Pathogens . 17 ( 6 ) : e1009643

DOI: 10.1371/journal.ppat.1009643

Journal article

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Adapting French COVID-19 vaccination campaign duration to variant dissemination

Simon Pageaud, Nicolas Ponthus, Romain Gauchon, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel...

: p. 24

Report

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Adherence to cysteamine in nephropathic cystinosis: A unique electronic monitoring experience for a better understanding. A prospective cohort study: CrYSTobs

S. Gaillard, L. Roche, S. Lemoine, G. Deschênes, D. Morin, C. Vianey-Saban...

Pediatric Nephrology . 36 ( 3 ) : 581-589

DOI: 10.1007/s00467-020-04722-0

Journal article

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Prevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis

Sabine Mainbourg, Alexandra Addario, Maxime Samson, Xavier Puéchal, Mathilde François, Stéphane Durupt...

Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849

DOI: 10.1002/acr.23901

Journal article

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Phtirioses bovines. Traitement et gestion des échecs aux traitements

Laurent Bourguignon, Lionel Zenner

Bulletin des Groupements Techniques Vétérinaires . ( 97 ) : 69-74

Journal article

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Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

M. Pamela Griffin, Yuan Yuan, Therese Takas, Joseph Domachowske, Shabir Madhi, Paolo Manzoni...

New England Journal of Medicine . 383 ( 5 ) : 415-425

DOI: 10.1056/NEJMoa1913556

Journal article

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Role of ultrasonography in the assessment of correct endotracheal tube placement in neonates

Claire‐sophie Descamps, Anne Beissel, Philippe Vo Van, Marine Butin, Nicolas Stacoffe, Joris Giai...

Acta Paediatrica . 109 ( 5 ) : 1057-1059

DOI: 10.1111/apa.15097

Journal article

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French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)

Benjamin Terrier, Raphaël Darbon, Cécile-Audrey Durel, Eric Hachulla, Alexandre Karras, Hélène Maillard...

Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351

DOI: 10.1186/s13023-020-01621-3

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega...

Arthritis Research & Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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Attention and Executive Disorders in Neurofibromatosis 1: Comparison Between NF1 With ADHD Symptomatology (NF1 + ADHD) and ADHD Per Se

Laurence Lion-François, Vania Herbillon, Emeline Peyric, Catherine Mercier, Daniel Gérard, Tiphanie Ginhoux...

Journal of attention disorders . 24 ( 13 ) : 1807-1823

DOI: 10.1177/1087054717707579

Journal article

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Impact of terminating reimbursement of symptomatic slow-acting drugs in osteoarthritis in France on volume and cost of drug deliveries, assessed with administrative databases

K. Mari, F. Rannou, F. Guillemin, M. Elegbede, F. Gueyffier, G. Badot...

Seminars in Arthritis and Rheumatism . 50 : 1307 - 1313

DOI: 10.1016/j.semarthrit.2020.09.001

Journal article

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Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock

J. Tallon, B. Browning, F. Couenne, C. Bordes, F. Venet, P. Nony...

In Silico Biology . 13 ( 3-4 ) : 101-121

DOI: 10.3233/ISB-200474

Journal article

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Drug prescription goals in primary care: a cross-sectional study

Louis Bernard, René Écochard, François Gueyffier, Laurent Letrilliart

BMC Health Services Research . 20 ( 1 ) : 6

DOI: 10.1186/s12913-019-4870-y

Journal article

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Prevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis

Sabine Mainbourg, Alexandra Addario, Maxime Samson, Xavier Puéchal, Mathilde François, Stéphane Durupt...

Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849

DOI: 10.1002/acr.23901

Journal article

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Dosage de la tryptase : un guide d'utilisation pour le clinicien

H. Lobbes, Q. Reynaud, S. Mainbourg, J.C. Lega, I. Durieu, S. Durupt

La Revue de Médecine Interne . 41 : 748 - 755

DOI: 10.1016/j.revmed.2020.06.006

Journal article

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L'acéruléoplasminémie héréditaire, une pathologie à ne pas méconnaître

H. Lobbes, Q. Reynaud, S. Mainbourg, J-C. Lega, I. Durieu, S. Durupt

La Revue de Médecine Interne . 41 : 769 - 775

DOI: 10.1016/j.revmed.2020.06.002

Journal article

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Recurrent superficial vein thrombosis revealing relapsing polychondritis associated with myelodysplastic syndrome

Axel Tabary, Jean-Christophe Lega, Sabine Mainbourg, Hervé Lobbes

Rheumatology . 59 ( 11 ) : 3581-3581

DOI: 10.1093/rheumatology/keaa185

Journal article

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ANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance

Benjamin Terrier, Pierre Charles, Olivier Aumaître, Alexandre Bélot, Bernard Bonnotte, Yoann Crabol...

La Presse Médicale . 49 ( 3 ) : 104031

DOI: 10.1016/j.lpm.2020.104031

Journal article

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The benefit–risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials

Natalia Cabrera, Gabriela Avila-Pedretti, Alexandre Belot, Jean-Paul Larbre, Sabine Mainbourg, Agnès Duquesne...

Rheumatology . 59 ( 9 ) : 2226-2236

DOI: 10.1093/rheumatology/keaa170

Journal article

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Rectal endometriosis: predictive MRI signs for segmental bowel resection

Pascal Rousset, Guillaume Buisson, Jean-Christophe Lega, Mathilde Charlot, Colin Gallice, Eddy Cotte...

European Radiology . 31 ( 2 ) : 884-894

DOI: 10.1007/s00330-020-07170-4

Journal article

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Severe infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis

Clémence Thery-Casari, Romain Euvrard, Sabine Mainbourg, Stéphane Durupt, Quitterie Reynaud, Isabelle Durieu...

Autoimmunity Reviews . 19 ( 5 ) : 102505

DOI: 10.1016/j.autrev.2020.102505

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega...

Arthritis Research & Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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Analysis of ncidence of hrombotic omplications in the resence of ompeting isks

Sabine Mainbourg, Michel Cucherat, Jean-Christophe Lega

Thrombosis Research . 191 : 152

DOI: 10.1016/j.thromres.2020.04.045

Journal article

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Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

Tristan Ferry, Thomas Lodise, Jason Gallagher, Emmanuel Forestier, Sylvain Goutelle, Vincent Tam...

Frontiers in Medicine . 7 : 585658

DOI: 10.3389/fmed.2020.585658

Journal article

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Nonparametric Methods in Population Pharmacokinetics

Sylvain Goutelle, Jean-Baptiste Woillard, Michael Neely, Walter Yamada, Laurent Bourguignon, Jean‐baptiste Woillard

Journal of Clinical Pharmacology . 62 ( 2 ) : 142-157

DOI: 10.1002/jcph.1650

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