Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 211 to 240 publications on 628 in total

ANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance

Benjamin Terrier, Pierre Charles, Olivier Aumaître, Alexandre Bélot, Bernard Bonnotte, Yoann Crabol...

La Presse Médicale . 49 ( 3 ) : 104031

DOI: 10.1016/j.lpm.2020.104031

Journal article

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The benefit–risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials

Natalia Cabrera, Gabriela Avila-Pedretti, Alexandre Belot, Jean-Paul Larbre, Sabine Mainbourg, Agnès Duquesne...

Rheumatology . 59 ( 9 ) : 2226-2236

DOI: 10.1093/rheumatology/keaa170

Journal article

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Rectal endometriosis: predictive MRI signs for segmental bowel resection

Pascal Rousset, Guillaume Buisson, Jean-Christophe Lega, Mathilde Charlot, Colin Gallice, Eddy Cotte...

European Radiology . 31 ( 2 ) : 884-894

DOI: 10.1007/s00330-020-07170-4

Journal article

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Severe infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis

Clémence Thery-Casari, Romain Euvrard, Sabine Mainbourg, Stéphane Durupt, Quitterie Reynaud, Isabelle Durieu...

Autoimmunity Reviews . 19 ( 5 ) : 102505

DOI: 10.1016/j.autrev.2020.102505

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega...

Arthritis Research & Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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Analysis of ncidence of hrombotic omplications in the resence of ompeting isks

Sabine Mainbourg, Michel Cucherat, Jean-Christophe Lega

Thrombosis Research . 191 : 152

DOI: 10.1016/j.thromres.2020.04.045

Journal article

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Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

Tristan Ferry, Thomas Lodise, Jason Gallagher, Emmanuel Forestier, Sylvain Goutelle, Vincent Tam...

Frontiers in Medicine . 7 : 585658

DOI: 10.3389/fmed.2020.585658

Journal article

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Nonparametric Methods in Population Pharmacokinetics

Sylvain Goutelle, Jean-Baptiste Woillard, Michael Neely, Walter Yamada, Laurent Bourguignon, Jean‐baptiste Woillard

Journal of Clinical Pharmacology . 62 ( 2 ) : 142-157

DOI: 10.1002/jcph.1650

Journal article

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Drug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction

Claire Le Corvaisier, Aude Capelle, Mathilde France, Laurent Bourguignon, Michel Tod, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 35 ( 2 ) : 208-216

DOI: 10.1111/fcp.12601

Journal article

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Azithromycin for COVID-19: More Than Just an Antimicrobial?

Nathalie Bleyzac, Sylvain Goutelle, Laurent Bourguignon, Michel Tod

Clinical Drug Investigation . 40 ( 8 ) : 683-686

DOI: 10.1007/s40261-020-00933-3

Journal article

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Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children

Hanen Marsit, Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Michel Ducher...

Clinical Pharmacokinetics . 59 ( 8 ) : 1049-1061

DOI: 10.1007/s40262-020-00877-z

Journal article

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A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk

Etienne Weisskopf, Monia Guidi, Céline Fischer, Myriam Bickle Graz, Etienne Beaufils, Kim An Nguyen...

British Journal of Clinical Pharmacology . 86 ( 8 ) : 1642-1653

DOI: 10.1111/bcp.14278

Journal article

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Adverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates

D. Ndour, H. Bouamari, J. Berthiller, O. Claris, F. Plaisant, K.A. Nguyen

Archives de Pédiatrie . 27 : 452 - 455

DOI: 10.1016/j.arcped.2020.08.007

Journal article

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Role of ultrasonography in the assessment of correct endotracheal tube placement in neonates

Claire‐sophie Descamps, Anne Beissel, Philippe Vo Van, Marine Butin, Nicolas Stacoffe, Joris Giai...

Acta Paediatrica . 109 ( 5 ) : 1057-1059

DOI: 10.1111/apa.15097

Journal article

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Clinical response to lumacaftor-ivacaftor in patients with cystic fibrosis according to baseline lung function

Pierre-Régis Burgel, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prevotat, Marlene Murris-Espin...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2020.06.012

Journal article

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Real-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis

Pierre-Régis Burgel, Anne Munck, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prévotat...

American Journal of Respiratory and Critical Care Medicine . 201 ( 2 ) : 188-197

DOI: 10.1164/rccm.201906-1227OC

Journal article

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Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients

Paul Briaud, Sylvère Bastien, Laura Camus, Marie Boyadjian, Philippe Reix, Catherine Mainguy...

Frontiers in Cellular and Infection Microbiology . 10 : 105996

DOI: 10.3389/fcimb.2020.00266

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Behal, Luc Mouthon, Gregory Pugnet, Jean-Christophe Lega...

Arthritis Research and Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)

Benjamin Terrier, Raphaël Darbon, Cécile-Audrey Durel, Eric Hachulla, Alexandre Karras, Hélène Maillard...

Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351

DOI: 10.1186/s13023-020-01621-3

Journal article

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Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Jérôme Hadjadj, Carla Noemi Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi...

Nature Communications . 11 ( 1 ) : 5341

DOI: 10.1038/s41467-020-18925-4

Journal article

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Assessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study

S. Trouillet-Assant, C. Albert Vega, A. Bal, J. A. Nazare, P. Fascia, A. Paul...

BMJ Open . 10 ( 11 ) : e041268

DOI: 10.1136/bmjopen-2020-041268

Journal article

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Inconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis

Sébastien Mateo, Julie Di Marco, Michel Cucherat, François Gueyffier, Gilles Rode

Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240

DOI: 10.1016/j.rehab.2019.05.008

Journal article

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Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Alexandre Belot, Gillian Rice, Sulliman Ommar Omarjee, Quentin Rouchon, Eve Smith, Marion Moreews...

The Lancet Rheumatology . 2 ( 2 ) : e99-e109

DOI: 10.1016/S2665-9913(19)30142-0

Journal article

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Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials

Aurélien Hugues, Julie Di Marco, Isabelle Bonan, Gilles Rode, Michel Cucherat, François Gueyffier

PLoS ONE . 15 ( 3 ) : e0229822

DOI: 10.1371/journal.pone.0229822

Journal article

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Syndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?

Jordan Teoli, Claire Bardel, Marie Fablet, Gabriel Marais, François Gueyffier, Jean-François Lemaître...

36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194

DOI: 10.1016/j.ando.2020.07.150

Conference paper

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Collaboration between academics, small pharmaceutical company and patient organizations in the development of a new formulation of cysteamine in nephropathic cystinosis: A successful story

Ségolène Gaillard, Laurent Roche, Georges Deschênes, Denis E. J. Morin, Christine Vianey-Saban, Cécile Acquaviva-Bourdain...

Thérapie . 75 ( 2 ) : 169--173

DOI: 10.1016/j.therap.2020.02.008

Journal article

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Impact of prone positioning in infants with Pierre Robin sequence: a polysomnography study

L. Coutier, A. Guyon, Philippe Reix, P. Franco

Sleep Medicine . 54 : 257 - 261

DOI: 10.1016/j.sleep.2018.10.037

Journal article

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Diaphragmatic paralysis in young children: A literature review

Nathalie Gerard-Castaing, Thomas Perrin, Camille Ohlmann, Catherine Mainguy, Laurianne Coutier, Clelia Buchs...

Pediatric Pulmonology . 54 ( 9 ) : 1367-1373

DOI: 10.1002/ppul.24383

Journal article

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Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 ) : 102361

DOI: 10.1016/j.autrev.2019.102361

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/S0140-6736(19)31675-7

Journal article

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