Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 301 to 330 publications on 613 in total

Health related quality of life in infants and children with interstitial lung disease: a national pilot survey in France.

Clara Lauby, Pierre-Yves Boëlle, Ralph Epaud, Jacques de Blic, Rola Abou Taam, Philippe Reix...

Congrès Francophone Pédiatrique de Pneumologie et d’Allergologie .

Poster

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Hémosidérose idiopathique pulmonaire de l’enfant et trisomie 21: une étude nationale.

Aurélia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

Congrès Francophone Pédiatrique de Pneumologie et d’Allergologie .

Poster

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Acute chest pain in an adolescent with cystic fibrosis in September: Would you have thought about this?

Hiba Dowaikh, Florence Morfin-Sherpa, Philippe Reix

Pediatric Pulmonology . 52 ( 10 ) : E70-E72

DOI: 10.1002/ppul.23746

Journal article

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A simplified, semi-quantitative structural lung disease computed tomography outcome during quiet breathing in infants with cystic fibrosis

Magali Saguintaah, Yann Cabon, Rémi Gauthier, Cécile Duboibaudry, Laure Couderc, Muriel Le Bourgeois...

Journal of Cystic Fibrosis . 16 ( 1 ) : 151 - 157

DOI: 10.1016/j.jcf.2016.10.014

Journal article

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Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors

Xavier Puechal, Christian Pagnoux, Gabriel Baron, Thomas Quemeneur, Antoine Néel, Christian Agard...

Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186

DOI: 10.1002/art.40205

Journal article

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Isolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases

Sabine Jardel, Nicole Fabien, Arnaud Hot, Sandra Vukusic, Jacques Tebib, Vincent Cottin...

PLoS ONE . 12 ( 9 )

DOI: 10.1371/journal.pone.0185104

Journal article

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Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome

Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Jean-Christophe Lega, Marc Lambert, Sophie Rivière...

The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27

DOI: 10.1016/j.amjmed.2017.05.023

Journal article

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A sudden death risk score specifically for hypertension

Hai-Ha Le, Fabien Subtil, Marc Cerou, Ivanny Marchant, Muaamar Al-Gobari, Mor Fall...

Journal of Hypertension . 35 ( 11 ) : 2178-2184

DOI: 10.1097/HJH.0000000000001451

Journal article

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Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Laurence Pages-Monteiro, Romain Martin, Carine Commun, Nolwenn Alliot, Claire Bardel, Hélène Meugnier...

PLoS ONE . 12 ( 3 ) : 1-19

DOI: 10.1371/journal.pone.0173022

Journal article

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Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, A. Metge...

Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264

DOI: 10.1111/fcp.12263

Journal article

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Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier

Thérapie . 72 ( 5 ) : 609 - 613

DOI: 10.1016/j.therap.2017.02.004

Journal article

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Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

Aurélien Hugues, Julie Di Marco, Perrine Janiaud, Y Xue, Jennifer Pires, Hooman Khademi...

BMJ Open . 7 ( 1 ) : e013348

DOI: 10.1136/bmjopen-2016-013348

Journal article

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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

Journal article

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

Journal article

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

Journal article

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

Journal article

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Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?

C. Mainguy, G. Bellon, V. Delaup, T. Ginoux, B. Kassai-Koupai, S. Mazur...

Journal of pediatric endocrinology & metabolism . 30 : 27-35

DOI: 10.1515/jpem-2016-0184

Journal article

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Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Céline Pouzot Pouzot-Névoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz...

International Journal of Antimicrobial Agents .

DOI: 10.1016/j.ijantimicag.2017.03.029

Journal article

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Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes & Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

Journal article

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No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

Journal article

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

Journal article

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

Journal article

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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 56 : 435-447

DOI: 10.1007/s40262-016-0448-6

Journal article

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. de La Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

Journal article

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Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Nathalie Eymard, Vitaly Volpert, Polina Kurbatova, Nikolai Bessonov, Kayode Ogungbenro, Leon Aarons...

Mathematical Medicine and Biology .

DOI: 10.1093/imammb/dqw019

Journal article

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Phone-based safety monitoring of the first year of baclofen treatment for alcohol use disorder: the baclophone cohort study protocol

Benjamin Rolland, Marine Auffret, Julien Labreuche, Maryse Lapeyre-Mestre, Malek Dib, Aomar Kemkem...

Expert Opinion on Drug Safety . 16 ( 2 ) : 125-132

DOI: 10.1080/14740338.2017.1270939

Journal article

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Proactive Regional Pharmacovigilance System Versus National Spontaneous Reporting for Collecting Safety Data on Concerning Off-Label Prescribing Practices: An Example with Baclofen and Alcohol Dependence in France

Marine Auffret, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Olivier Cottencin, Regis Bordet...

Drug Safety . 40 : 257-262

DOI: 10.1007/s40264-016-0489-7

Journal article

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A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients

Aurore Curie, Amandine Brun, Anne Cheylus, Anne Reboul, Tatjana Nazir, Gérald Bussy...

PLoS ONE . 11 ( 2 ) : e0149717

DOI: 10.1371/journal.pone.0149717

Journal article

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ADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate

S. Rheims, V. Herbillon, N. Villeneuve, S. Auvin, S. Napuri, C. Cances...

Epilepsia . 57 : 1069-77

DOI: 10.1111/epi.13420

Journal article

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Safety study of Ciprofloxacin in newborn mice

T. Bourgeois, Al. Delezoide, W. Zhao, F. Guimiot, H. Adle-Biassette, E. Durand...

Regulatory Toxicology and Pharmacology . 74 : 161-169

DOI: 10.1016/j.yrtph.2015.11.002

Journal article

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