Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 301 to 330 publications on 628 in total

Determinants of amikacin first peak concentration in critically ill patients

Clément Boidin, Sophie Jenck, Laurent Bourguignon, Sejad Torkmani, Aurore Roussey-Jean, Stanislas Ledochowski...

Fundamental & Clinical Pharmacology .

DOI: 10.1111/fcp.12374

Journal article

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Sex gap in aging and longevity: can sex chromosomes play a role?

Gabriel A.B. Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier...

Biology of Sex Differences . 9 ( 1 ) : 1-14

DOI: 10.1186/s13293-018-0181-y

Journal article

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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 62 ( 1 )

DOI: 10.1128/AAC.01413-17

Journal article

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A double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms

Catherine Cornu, Catherine Mercier, Tiphanie Ginhoux, Sandrine Masson, Julie Mouchet, Patrice Nony...

European Child and Adolescent Psychiatry . 27 ( 3 ) : 377-384

DOI: 10.1007/s00787-017-1058-z

Journal article

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Justification de la prescription hors-AMM d’antibiotiques chez l’enfant hospitalisé

Christelle Berthod, Behrouz Kassaï, Remy Boussageon, Léopold Adelaide, Matthias Jacquet-Lagrèze, Audrey Lajoinie...

Therapies . 72 ( 6 ) : 649-658

DOI: 10.1016/j.therap.2017.04.002

Journal article

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Real-life acute lung function changes after lumacaftor/ivacaftor first administration in pediatric patients with cystic fibrosis

Aurélie Labaste, Camille Ohlmann, Catherine Mainguy, Virginie Jubin, Marie Perceval, Laurianne Coutier...

Journal of Cystic Fibrosis . 16 ( 6 ) : 709-712

DOI: 10.1016/j.jcf.2017.05.002

Journal article

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Les enjeux de sécurité de la prescription hors AMM : l’exemple du baclofène dans l’alcoolodépendance

Marine Auffret

Thesis

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The dose–effect relationship of baclofen in alcohol dependence: A 1-year cohort study

Baptiste Pignon, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin...

Human Psychopharmacology. Clinical and Experimental . 32 ( 4 )

DOI: 10.1002/hup.2593

Journal article

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Authors' reply to alain braillon's comment on

Marine Auffret, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Olivier Cottencin, Regis Bordet...

Drug Safety . 40 : 361-362

DOI: 10.1007/s40264-017-0513-6

Journal article

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Familial and syndromic lupus share the same phenotype as other early-onset forms of lupus.

Olivia Weill, Stéphane Decramer, Christophe Malcus, Behrouz Kassai, Isabelle Rouvet, Tiphanie Ginhoux...

Joint Bone Spine . : 589-593

DOI: 10.1016/j.jbspin.2016.12.008

Journal article

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Trends in the number and the quality of trial protocols involving children submitted to a French Institutional Review Board

Isabelle Gautier, Perrine Janiaud, Nelly Rollet, Nicolas André, Michel Tsimaratos, Catherine Cornu...

BMC Medical Research Methodology . 17 ( 1 ) : 130

DOI: 10.1186/s12874-017-0395-4

Journal article

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Worldwide view of nephropathic cystinosis: results from a survey from 30 countries

Aurélia Bertholet-Thomas, Julien Berthiller, Velibor Tasic, Behrouz Kassai, Hasan Otukesh, Marcella Greco...

BMC Nephrology . 18 ( 1 ) : 210

DOI: 10.1186/s12882-017-0633-3

Journal article

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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?

M Tod, Sylvain Goutelle, L Bourguignon, N Bleyzac

CPT: Pharmacometrics and Systems Pharmacology . 6 ( 4 ) : 226-226

DOI: 10.1002/psp4.12164

Journal article

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Health related quality of life in infants and children with interstitial lung disease: a national pilot survey in France.

Clara Lauby, Pierre-Yves Boëlle, Ralph Epaud, Jacques de Blic, Rola Abou Taam, Philippe Reix...

Congrès Francophone Pédiatrique de Pneumologie et d’Allergologie .

Poster

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Hémosidérose idiopathique pulmonaire de l’enfant et trisomie 21: une étude nationale.

Aurélia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

Congrès Francophone Pédiatrique de Pneumologie et d’Allergologie .

Poster

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Acute chest pain in an adolescent with cystic fibrosis in September: Would you have thought about this?

Hiba Dowaikh, Florence Morfin-Sherpa, Philippe Reix

Pediatric Pulmonology . 52 ( 10 ) : E70-E72

DOI: 10.1002/ppul.23746

Journal article

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A simplified, semi-quantitative structural lung disease computed tomography outcome during quiet breathing in infants with cystic fibrosis

Magali Saguintaah, Yann Cabon, Rémi Gauthier, Cécile Duboibaudry, Laure Couderc, Muriel Le Bourgeois...

Journal of Cystic Fibrosis . 16 ( 1 ) : 151 - 157

DOI: 10.1016/j.jcf.2016.10.014

Journal article

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Isolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases

Sabine Jardel, Nicole Fabien, Arnaud Hot, Sandra Vukusic, Jacques Tebib, Vincent Cottin...

PLoS ONE . 12 ( 9 )

DOI: 10.1371/journal.pone.0185104

Journal article

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Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors

Xavier Puechal, Christian Pagnoux, Gabriel Baron, Thomas Quemeneur, Antoine Néel, Christian Agard...

Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186

DOI: 10.1002/art.40205

Journal article

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Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome

Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Jean-Christophe Lega, Marc Lambert, Sophie Rivière...

The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27

DOI: 10.1016/j.amjmed.2017.05.023

Journal article

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A sudden death risk score specifically for hypertension

Hai-Ha Le, Fabien Subtil, Marc Cerou, Ivanny Marchant, Muaamar Al-Gobari, Mor Fall...

Journal of Hypertension . 35 ( 11 ) : 2178-2184

DOI: 10.1097/HJH.0000000000001451

Journal article

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Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Laurence Pages-Monteiro, Romain Martin, Carine Commun, Nolwenn Alliot, Claire Bardel, Hélène Meugnier...

PLoS ONE . 12 ( 3 ) : 1-19

DOI: 10.1371/journal.pone.0173022

Journal article

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Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, A. Metge...

Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264

DOI: 10.1111/fcp.12263

Journal article

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Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier

Thérapie . 72 ( 5 ) : 609 - 613

DOI: 10.1016/j.therap.2017.02.004

Journal article

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Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

Aurélien Hugues, Julie Di Marco, Perrine Janiaud, Y Xue, Jennifer Pires, Hooman Khademi...

BMJ Open . 7 ( 1 ) : e013348

DOI: 10.1136/bmjopen-2016-013348

Journal article

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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

Journal article

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

Journal article

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

Journal article

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

Journal article

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Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?

C. Mainguy, G. Bellon, V. Delaup, T. Ginoux, B. Kassai-Koupai, S. Mazur...

Journal of pediatric endocrinology & metabolism . 30 : 27-35

DOI: 10.1515/jpem-2016-0184

Journal article

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