Evaluation and Modeling with the Therapeutic Effects Group
Members

Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87

Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18

Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83

Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99

Praticienne hospitalière
HCL

Praticien hospitalier
HCL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier émérite
UCBL

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01

Post-doc
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Doctorante
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Stagiaire
UCBL

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Doctorante
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 301 to 330 publications on 654 in total
Immune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Book chapter
see the publicationDo non-steroidal anti-inflammatory drugs improve sport performance ? A meta-analysis of randomized trials Introduction
23e Congrès de la Société Française de Pharmacologie et de Thérapeutique (SFPT 2019) .
Poster
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationClomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies
BJOG: An International Journal of Obstetrics and Gynaecology .
Journal article
see the publicationLong‐term extrapulmonary comorbidities after lung transplantation in cystic fibrosis: Update of specificities
Clinical Transplantation . 32 ( 6 )
DOI: 10.1111/ctr.13269
Journal article
see the publicationRisk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.
Rheumatology . 57 : 1432–1438
Journal article
see the publicationA Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4
Clinical Pharmacokinetics . 58 ( 4 ) : 503-523
Journal article
see the publicationComment on: MIC-based dose adjustment: facts and fables
Journal of Antimicrobial Chemotherapy . 73 ( 9 ) : 2584-2585
DOI: 10.1093/jac/dky131
Journal article
see the publicationPopulation Pharmacokinetic Study of Amoxicillin-Treated Burn Patients Hospitalized at a Swiss Tertiary-Care Center
Antimicrobial Agents and Chemotherapy . 62 ( 9 )
DOI: 10.1128/AAC.00505-18
Journal article
see the publicationMaximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children
Bone Marrow Transplantation . 54 ( 3 ) : 448-457
Journal article
see the publication[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].
Annales de Cardiologie et d'Angéiologie . 67 ( 2 ) : 91-97
Journal article
see the publicationIdentification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model
Clinical Pharmacokinetics . 57 ( 12 ) : 1581-1591
Journal article
see the publicationTranscriptional regulation of CRMP5 controls neurite outgrowth through Sox5
Cellular and Molecular Life Sciences . 75 ( 1 ) : 67-79
Journal article
see the publicationFunctional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer.
uropean Respiratory Society (ERS) Congress, .
Conference paper
see the publicationFunctional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer28th International Congress of the European-Respiratory-Society (ERS)
28th International Congress of the European-Respiratory-Society (ERS) .
Conference paper
see the publicationDown syndrome and pulmonary hemosiderosis: an under-recognized association
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationContribution of mutations in genes of the surfactant system to idiopathic interstitial pneumonia (IIP)
ERS International Congress 2018 abstracts . : OA547
Conference paper
see the publicationPlace de l’analyse des gènes du surfactant dans la démarche diagnostique des pneumopathies interstitielles diffuses de l’enfant et l’adulte
Assises de Génétique Humaine et Médicale .
Poster
see the publicationEosinophilic granulomatosis with polyangiitis in children: Data from the French RespiRare (R) cohort
Pediatric Pulmonology . 53 ( 12 ) : 1640-1650
DOI: 10.1002/ppul.24089
Journal article
see the publicationPulmonary hemosiderosis in children with Down syndrome: a national experience
Orphanet Journal of Rare Diseases . 13 ( 1 ) : 60
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publicationPediatric renal transplantation: A retrospective single-center study on epidemiology and morbidity due to EBV
Pediatric Transplantation . 22 ( 3 ) : e13151
DOI: 10.1111/petr.13151
Journal article
see the publicationGlucose trajectories in cystic fibrosis and their association with pulmonary function
Journal of Cystic Fibrosis . 17 ( 3 ) : 400 - 406
Journal article
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationProspective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy
ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )
DOI: 10.1128/AAC.00163-18
Journal article
see the publicationAntituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages
Tuberculosis . 111 : 67-70
Journal article
see the publicationDeterminants of amikacin first peak concentration in critically ill patients
Fundamental & Clinical Pharmacology .
DOI: 10.1111/fcp.12374
Journal article
see the publicationSex gap in aging and longevity: can sex chromosomes play a role?
Biology of Sex Differences . 9 ( 1 ) : 1-14
Journal article
see the publicationAssessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling
Antimicrobial Agents and Chemotherapy . 62 ( 1 )
DOI: 10.1128/AAC.01413-17
Journal article
see the publicationA double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms
European Child and Adolescent Psychiatry . 27 ( 3 ) : 377-384
Journal article
see the publication
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