Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 1 to 30 publications on 170 in total

Estimating individualized treatment effects using an individual participant data meta-analysis

Florie Bouvier, Anna Chaimani, Etienne Peyrot, François Gueyffier, Guillaume Grenet, Raphaël Porcher

BMC Medical Research Methodology . 24 ( 1 ) : 74

DOI: 10.1186/s12874-024-02202-9

Journal article

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Fondamentaux de l’évaluation des thérapeutiques, médicamenteuses et non médicamenteuses – un cadre pour l’évaluation des processus d’autoguérison

François Gueyffier, Rémy Boussageon

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 347-358

DOI: 10.3917/heg.134.0347

Journal article

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Qu’est-ce qu’une thérapeutique ? Analyse conceptuelle de la notion de placebo, d’effet placebo, d’effet spécifique et de thérapeutique

Rémy Boussageon, François Gueyffier, Alain Moreau, Virgile Serrau, Widiane Ferchakhi

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 325-334

DOI: 10.3917/heg.134.0325

Journal article

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Olaparib in recurrent isocitrate dehydrogenase mutant high-grade glioma: A phase 2 multicenter study of the POLA Network

Ines Esparragosa Vazquez, Marc Sanson, Olivier Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

Neuro-Oncology Advances . 6 ( 1 )

DOI: 10.1093/noajnl/vdae078

Journal article

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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health

Antoine Vanier, Judith Fernandez, Sophie Kelley, Lise Alter, Patrick Semenzato, Corinne Alberti...

BMJ Evidence-Based Medicine . 29 ( 1 ) : 1-5

DOI: 10.1136/bmjebm-2022-112091

Journal article

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Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Therapies . 78 ( 5 ) : S11-S18

DOI: 10.2515/therapie/2015042

Journal article

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Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Pierre-Yves Meunier, Camille Raynaud, Emmanuelle Guimaraes, François Gueyffier, Laurent Letrilliart

Journal of Critical Care . 78 ( 1 ) : 154330

DOI: 10.1370/afm.2908

Journal article

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[Does aspirin have a place in primary cardiovascular prevention by the polypill ? Simulation study on a realistic virtual population].

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

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Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care

Constanza Serón, Pablo Olivero, Nicolás Flores, Benjamín Cruzat, Francisca Ahumada, François Gueyffier...

Frontiers in Public Health . 11 ( 1 ) : 1270557

DOI: 10.3389/fpubh.2023.1270557

Journal article

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Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

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Project Rebuild the Evidence Base (REB): a method to interpret randomised clinical trials and their meta-analysis to present solid benefit-risk assessments to patients

Rémy Boussageon, Clara Blanchard, Elodie Charuel, Thibault Menini, Bruno Pereira, Florian Naudet...

Therapies . 78 ( 4 ) : 353-365

DOI: 10.1016/j.therap.2022.10.008

Journal article

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L’aspirine a-t-elle une place dans la prévention cardiovasculaire primaire par la polypill ? Étude de simulation sur une population virtuelle réaliste

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Charles-Hervé Vacheron, Alain Lepape, Fabienne Venet, Guillaume Monneret, Francois Gueyffier, Florent Boutitie...

Journal of Critical Care . 78 : 154330

DOI: 10.1016/j.jcrc.2023.154330

Journal article

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Preuves de bénéfice et décision thérapeutique : enquête auprès de médecins généralistes sur la prescription d’hydroxychloroquine pour traiter la Covid-19

Remy de Castro, Michelle Johnson, Florian Naudet, Denis Pouchain, François Gueyffier, Laurent Letrilliart...

Exercer . 34 ( 195 ) : 298-304

DOI: 10.56746/EXERCER.2023.195.298

Journal article

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A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

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Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

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Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

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Estimating individualized treatment effects using individual participant data meta-analysis

Florie Brion Bouvier, Anna Chaimani, François Gueyffier, Guillaume Grenet, Raphaël Porcher

Preprint

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A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial

Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Alloh, Catherine Cornu...

BMC Cancer . 22 ( 1 ) : 575

DOI: 10.1186/s12885-022-09564-7

Journal article

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SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

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Indirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis

Sabine Mainbourg, Axel Tabary, Michel Cucherat, François Gueyffier, Hervé Lobbes, Marie Aussedat...

Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835

DOI: 10.1016/j.mayocp.2022.03.010

Journal article

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Needs for re-intervention on restored teeth in adults: a practice-based study

Franck Decup, Emmanuelle Dantony, Charlène Chevalier, Alexandra David, Valentin Garyga, Marie Tohmé...

Clinical Oral Investigations . 26 ( 1 ) : 789-801

DOI: 10.1007/s00784-021-04058-5

Journal article

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Predicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France

Simon Pageaud, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe, Nicolas Leboisne, Catherine Pothier...

Vaccines . 10 ( 12 ) : 2033

DOI: 10.3390/vaccines10122033

Journal article

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Selected and simplified FDI criteria for assessment of restorations

Christina Maillet, Franck Decup, Emmanuelle Dantony, Jean Iwaz, Charlène Chevalier, François Gueyffier...

Journal of Dentistry . 122 : 104109

DOI: 10.1016/j.jdent.2022.104109

Journal article

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Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions

Marie-Agnès Gasqui, Matthieu Perard, Franck Decup, Paul Monsarrat, Yann-Loïg Turpin, Cyril Villat...

Oral Radiology . 38 ( 1 ) : 89-98

DOI: 10.1007/s11282-021-00530-w

Journal article

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How do they add up? The interaction between the placebo and treatment effect: A systematic review

Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika-Germaneau...

British Journal of Clinical Pharmacology . 88 ( 8 ) : 3638-3656

DOI: 10.1111/bcp.15345

Journal article

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Olaparib in recurrent IDH-mutant high-grade glioma (OLAGLI)

François Ducray, Marc Sanson, Olivier Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15S ) : 2007

Conference paper

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Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis

S. Mainbourg, M. Cucherat, S. Provencher, L. Bertoletti, P. Nony, F. Gueyffier...

Thrombosis Research . 197 : 24-32

DOI: 10.1016/j.thromres.2020.10.011

Journal article

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Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis

S. Mainbourg, M. Cucherat, S. Provencher, L. Bertoletti, P. Nony, F. Gueyffier...

Thrombosis Research . 197 : 24 - 32

DOI: 10.1016/j.thromres.2020.10.011

Journal article

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