Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 541 to 570 publications on 613 in total

[Amikacin pharmacokinetics in adults: a variability that question the dose calculation based on weight].

Laurent Bourguignon, Sylvain Goutelle, Cécile Gérard, Anne Guillermet, Julie Burdin de Saint Martin, Pascal Maire...

Therapies . 64 ( 1 ) : 47-53

DOI: 10.2515/therapie/2009009

Journal article

see the publication

Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells.

Taïssia Lelekov-Boissard, Guillemette Chapuisat, Jean-Pierre Boissel, Emmanuel Grenier, Marie-Aimée Dronne

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences . 367 ( 1908 ) : 4699-4716

DOI: 10.1098/rsta.2009.0184

Journal article

see the publication

A mathematical approach to model stroke pathophysiology

Marie-Aimée Dronne, Emmanuel Grenier, Thierry Dumont, Marc Hommel, Jean-Pierre Boissel

International Heart Forum .

Conference paper

see the publication

Examples of the influence of the geometry on the propagation of progressive waves

Marie-Aimée Dronne, Stéphane Descombes, Emmanuel Grenier, Hervé Gilquin

Mathematical and Computer Modelling . 49 ( 11-12 ) : 2138-2144

DOI: 10.1016/j.mcm.2008.07.024

Journal article

see the publication

New surfactant protein C gene mutations associated with diffuse lung disease

Loïc Guillot, Ralph Epaud, Guillaume Thouvenin, Laurence Jonard, Amira Mohsni, Remy Couderc...

Journal of Medical Genetics . 46 ( 7 ) : 490

DOI: 10.1136/jmg.2009.066829

Journal article

see the publication

Cognitive Therapy versus Rogerian Supportive Therapy in Borderline Personality Disorder

J. Cottraux, I. Druon Note, F. Boutitie, M. Milliery, V. Genouihlac, S.N. Yao...

Psychotherapy and Psychosomatics . 78(5) : 307-316

Journal article

see the publication

Modélisation pharmacocinétique-pharmacodynamique et techniques de simulation appliquées à l’évaluation de stratégies thérapeutiques en infectiologie

Laurent Bourguignon

Thesis

see the publication

A positioning pillow to improve lumbar puncture success rate in paediatric haematology-oncology patients: a randomized controlled trial

P. Marec-Bérard, A. Bissery, K. Kebaïli, M. Schell, F. Aubert, Sophie Gaillard...

BMC Cancer . 9(21) : 1399-1406

Journal article

see the publication

Fondements de l`évaluation des tests diagnostiques

B. Kassai, François Gueyffier, Muriel Rabilloud

Lecture critique d`article . 59 : 375-379

Journal article

see the publication

Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.

Albert Fournier, Roxana Oprisiu-Fournier, Jean-Marie Serot, Olivier Godefroy, Jean-Michel Achard, Sébastien Faure...

Expert Review of Neurotherapeutics . 9 ( 9 ) : 1413-31

DOI: 10.1586/ern.09.89

Journal article

see the publication

Recueil systématique et actif des evènements indésirables médicamenteux chez les enfants admis aux urgences pédiatriques

F. Planchamp, K.-A. Nguyen, T. Vial, S. Nasri, E. Javouhey, Y. Gillet...

Archives de Pédiatrie . 16(2) : 106-111

Journal article

see the publication

SCORE should be preferred to Framingham to predict cardiovascular death in French population

I. Marchant, J-P. Boissel, Behrouz Kassai, T. Bejan-Angoulvant, J. Massol, C. Vidal...

European Journal of Cardiovascular Prevention and Rehabilitation . 16(5) : 609-615

Journal article

see the publication

Evaluation of various gentamicin dosage regimens in geriatric patients: a simulation study

Laurent Bourguignon, Sylvain Goutelle, J. Burdin de Saint Martin, P. Maire, M. Ducher

Fundamental & Clinical Pharmacology . -- : 1-5

Journal article

see the publication

Modification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination

Sylvain Goutelle, Laurent Bourguignon, M. Ducher, P. Maire

The Annals of Pharmacotherapy . 43 : 1143-1146

Journal article

see the publication

Variabilité pharmacocinétique intra-individuelle et traitement antibiotique prolongé

Laurent Bourguignon, Sylvain Goutelle, Julie Burdin de Saint Martin, Anne Guillermet, P. Bouniot, Pascal Maire...

Médecine et Maladies Infectieuses . 2859 : 38-41

DOI: 10.1016/j.medmal.2009.03.003

Journal article

see the publication

Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Sylvain Goutelle, Laurent Bourguignon, P. Maire, M. van Guilder, J.-D. Conte, R.-W. Jelliffe

Antimicrobial Agents and Chemotherapy . 53(7) : 2974-2981

Journal article

see the publication

Patient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance

Moreau Alain, Vincent Aroles, Gilbert Souweine, Marie Flori, Sylvie Erpeldinger, Sophie Figon...

European Journal of General Practice . ( 15 ) : 147-53.

Journal article

see the publication

Patient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance

Moreau Alain, Vincent Aroles, Gilbert Souweine, Marie Flori, Sylvie Erpeldinger, Sophie Figon...

European Journal of General Practice . 15 ( 3 ) : 147-153

Journal article

see the publication

Pharmacocinétique de l'amikacine chez l'adulte : une hétérogénéité qui remet en cause le calcul de la dose basé sur le poids

Laurent Bourguignon, Sylvain Goutelle, C. Gérard, A. Guillermet, J. Burdin de Saint Martin, P. Maire...

Thérapie . 64 ( 1 ) : 189-194

Journal article

see the publication

Renal hypersensitivity' to inulin and IgA nephropathy

J. Bacchetta, F. Villard, T. Vial, L. Dubourg, R. Bouvier, Behrouz Kassai Koupai...

Pediatric Nephrology . 23 ( 10 ) : 1883-1885

DOI: 10.1007/s00467-008-0819-9

Journal article

see the publication

‘Renal hypersensitivity' to inulin and IgA nephropathy

J. Bacchetta, F. Villard, T. Vial, L. Dubourg, R. Bouvier, Behrouz Kassai...

Pediatric Nephrology . 23(10) : 1883-1885

Journal article

see the publication

Hypersensitivity to inulin : a rare and mostly benign event

J. Bacchetta, P. Cochat, F. Villard, M. Astier, T. Vial, L. Dubourg...

American Journal of Kidney Diseases . 52(3) : 632-633

Journal article

see the publication

Comment lire un article rapportant un test diagnostique?

Behrouz Kassai, J. Bacchetta

Médecine . 1 : 1-3

Journal article

see the publication

Critique du modèle additif de l'essai clinique randomisé

R. Boussageon, F. Gueyffier, T. Bejan-Angoulvant, Géraldine Felden

Thérapie . 63 ( 1 ) : 29-35

Journal article

see the publication

A modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients.

Marie-Aimée Dronne, Emmanuel Grenier, Guillemette Chapuisat, Marc Hommel, Jean-Pierre Boissel

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 60-78

DOI: 10.1016/j.pbiomolbio.2007.10.001

Journal article

see the publication

A numerical study of the blocking of migraine by Rolando sulcus.

Emmanuel Grenier, Marie-Aimée Dronne, Stéphane Descombes, Hervé Gilquin, Agnès Jaillard, Marc Hommel...

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 54-9

DOI: 10.1016/j.pbiomolbio.2007.10.002

Journal article

see the publication

Modelling methodology in physiopathology.

Jean-Pierre Boissel, Benjamin Ribba, Emmanuel Grenier, Guillemette Chapuisat, Marie-Aimée Dronne

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 28-39

DOI: 10.1016/j.pbiomolbio.2007.10.005

Journal article

see the publication

A global phenomenological model of ischemic stroke with stress on spreading depressions.

Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Hervé Gilquin, Jean-Pierre Boissel

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 4-27

DOI: 10.1016/j.pbiomolbio.2007.10.004

Journal article

see the publication

Behavior learning using emotional conditioning

Guillaume Grenet, Frédéric Alexandre

IROS Workshop "From motor to interaction learning in robots" .

Conference paper

see the publication

Effectiveness of home treatment for patients with cystic fibrosis: the intravenous administration of antibiotics to treat respiratory infections.

Anne Termoz, Sandrine Touzet, Stéphanie Bourdy, Evelyne Decullier, Laeticia Bouveret, Cyrille Colin...

Pediatric Pulmonology . 43 ( 9 ) : 908-15

DOI: 10.1002/ppul.20878

Journal article

see the publication

You also, comment on this article

Choose an avatar
(Will not be posted on the site)
(Will not be posted on the site)