Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 571 to 600 publications on 606 in total

Presentation of the French Network of Paediatric Clinical Investigation Centres (CIC.P)

E. Jacqz-Aigraina, Behrouz Kassaï

Fundamental & Clinical Pharmacology . 21 : 105--110

Journal article

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Role of astrocytes in grey matter during stroke: a modelling approach.

Marie-Aimée Dronne, Emmanuel Grenier, Thierry Dumont, Marc Hommel, Jean-Pierre Boissel

Brain Research . 1138 : 231-42

DOI: 10.1016/j.brainres.2006.12.062

Journal article

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When to stop in the quest of formes frustes of connective tissue disease ?

Vincent Cottin, Jean-Christophe Lega, Nicole Fabien, Jean-François Cordier

Clinical Rheumatology . 26 ( 4 ) : 615-616

Journal article

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Some reflexions about double blind

R. Boussageon, François Gueyffier, A. Moreau, Y. Gansel, V. Boussageon

L'Encéphale . 34(4) : 347-351

Journal article

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Do We Need to Assess the Effect of Treatment Withdrawal? The Paradigm of Life-Long Prevention

François Gueyffier, T. Bejan-Angoulvant

Journal of the American Hearth Association . -- : 219-226

Journal article

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Critères intermédiaires et critères de substitution

Behrouz Kassai, François Gueyffier, J-P. Boissel

Médecine Thérapeutique . 13(4) : 279-286

Journal article

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Severe myoclonic epilepsy in infancy: A systematic review and a meta-analysis of individual patient data

Behrouz Kassai, C. Chiron, S. Augier, Michel Cucherat, E. Rey, François Gueyffier...

Epilepsia . 48 : 1-6

Journal article

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Does a change in angiotensin-II-formation caused by antihypertensive drugs affect the risk of stroke ? A meta-analysis of trials according to treatment with potentially different effects on angiotensin-II

F. Boutitie, R. Oprisiu, J.M. Achard, H. Mazouz, J. Wang, F.H. Messerli...

Journal of Hypertension . 25 : 1543-1553

Journal article

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The JIKEI trial

F. Boutitie, François Gueyffier, Jm. Achard

The Lancet . 370 : 1825-1826

Journal article

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Literature search parameters marginally improved the pooled estimate accuracy for ultrasound in detecting deep venous thrombosis

Behrouz Kassai, S. Soniéb, N.R. Shah, J.-P. Boissel

Journal of Clinical Epidemiology . 59 : 710-714

Journal article

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La mise en place en Europe des réseaux d`investigation des médicaments chez l`enfant

Behrouz Kassai, J.M. Treluyer, E. Jacqz-Aigrain, Gérard Pons

Archives de Pédiatrie . 13 : 631-634

Journal article

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A mathematical model of ion movements in grey matter during a stroke

Marie-Aimée Dronne, Jean-Pierre Boissel, Emmanuel Grenier

Journal of Theoretical Biology . 240 : 599-615

Journal article

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The CF-CIRC study: a French collaborative study to assess the accuracy of cystic fibrosis diagnosis in neonatal screening.

Isabelle Sermet-Gaudelus, Delphine Roussel, Stéphanie Bui, Eric Deneuville, Frédéric Huet, Philippe Reix...

BMC Pediatrics . 6 : 25

DOI: 10.1186/1471-2431-6-25

Journal article

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Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

G. Monneret, A. Lepape, N. Voirin, J. Bohé, F. Venet, A.-L. Debard...

Intensive Care Medicine . 32 : 1175-1183

Journal article

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Cardiovascular Risk Stratification in Decision Support Systems: A Probabilistic Approach. Application to pHealth

H. Atoui, J. Fayn, François Gueyffier, P. Rubel

2006 Computers in Cardiology .

Conference paper

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The lower the better: Does simplicity lead to absurdity?

François Gueyffier, Jm. Wright

Editorial comment . 24(3) : 431-433

Journal article

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Safety of computerized drug management: a case report

K.-A. Nguyen, T. Vial, François Gueyffier, S. Marignier, P. Cochat, Behrouz Kassai

British Journal of Clinical Pharmacology . 63 : 245-246

Journal article

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Estimation of attributable burden of disease: authors' reply

François Gueyffier, Jm. Wright

Journal of Hypertension . 24 ( 5 ) : 933-936

Journal article

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L'attitude des parents face à la fièvre de leurs enfants

J. Stagnara, J. Vermont, F. Dürr, K. Ferradji, L. Mege, A. Duquesne...

Press Med . 34 : 1129-1136

Journal article

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Methods for evaluation of total cardiovascular risk

A. Barna, M. Baudet, J.-P. Cambou, G. Chatellier, Michel Cucherat, J. Dallongeville...

Médecine thérapeutique . 11 : 233--236

Journal article

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La modélisation des interactions en pharmacologie : un outil d'intégration des connaissances complexes

Samira Bakiri, Marie-Aimée Dronne, S. Randall Thomas, François Gueyffier

Arch Mal C'ur Vais . 98 : 61

Conference paper

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[Readability of informed consent forms for subjects participating in biomedical research: updating is required]

Adeline Paris, Jean-Luc Cracowski, Nadia Ravanel, Catherine Cornu, François Gueyffier, Béatrice Deygas...

La Presse Médicale . 34 ( 1 ) : 13-8

Journal article

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The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests

Behrouz Kassai, N.R. Shah, A. Leizorovicz, Michel Cucherat, François Gueyffier, J.-P. Boissel

Journal of Clinical Epidemiology . 58 : 1042-1051

Journal article

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Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome

J.-G. Wang, J.A. Staessen, S. Franklin, R. Fagard, François Gueyffier

Hypertension . 45(5) : 907-913

Journal article

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Apparent effect on blood pressure is only partly responsible for the risk reduction due to antihypertensive treatments

J.-P. Boissel, François Gueyffier, F. Boutitie, S. Pocock, R. Fagard

Fundamental & Clinical Pharmacology . 19 : 579-584

Journal article

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Modélisation numérique et simulation : nouvelles applications en pharmacologie [New approaches in pharmacology: numerical modelling and simulation]

Jean-Pierre Boissel, Michel Cucherat, Patrice Nony, Marie-Aimée Dronne, Behrouz Kassaï, Sylvie Chabaud

Thérapie . 60 ( 1 ) : 1-15

Journal article

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Should age influence the choice of quantitative bone assessment technique in elderly women? The EPIDOS study

A.-M. Schott, K.B. Kassaï, D. Hans, P. Dargent-Molina, R. Écochard, D.C. Bauer...

Osteoporosis International . 15 : 196-203

Journal article

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Mathematical modelling of an ischemic stroke: an integrative approach.

Marie-Aimée Dronne, Jean-Pierre Boissel, Emmanuel Grenier, Hervé Gilquin, Michel Cucherat, Marc Hommel...

Acta Biotheoretica . 52 ( 4 ) : 255-72

DOI: 10.1023/B:ACBI.0000046597.53669.ff

Journal article

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A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients

Behrouz Kassai, J.-P. Boissel, Michel Cucherat, S. Sonie, N.R. Shah, A. Leizorovicz

Thrombosis and Haemostasis . 91 : 655-666

Journal article

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Causality and statistical association (2) Mechanical determinism and stochastic model

François Gueyffier, Michel Cucherat

Revue du Praticien (La) . 53 : 933-936

Journal article

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