Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 481 to 510 publications on 613 in total

Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

Rémy Boussageon, Irène Supper, Theodora Bejan-Angoulvant, Nadir Kellou, Michel Cucherat, Jean-Pierre Boissel...

PLoS Medicine . 9 ( 4 ) : e1001204

DOI: 10.1371/journal.pmed.1001204

Journal article

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Apport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique

François Gueyffier, C. B. Strang, G. Berdeaux, L. R. França, P. Blin, J. Benichou...

Thérapie . 67 : 359--66

DOI: 10.2515/therapie/2012041

Journal article

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Contribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions

François Gueyffier, Cb. Strang, G. Berdeaux, Lr. Franca, P. Blin, J. Massol

Thérapie . 67 : 367--74

DOI: 10.2515/therapie/2012042

Journal article

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Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology

R. Moss, T. Grosse, I. Marchant, N. Lassau, François Gueyffier, S. R. Thomas

PLoS Computational Biology . 8 : e1002571

DOI: 10.1371/journal.pcbi.1002571

Journal article

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Efficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study

M. Bonnefoy, F. Boutitie, Catherine Mercier, François Gueyffier, C. Carre, G. Guetemme...

Journal of Nutrition, Health & Aging . 16 : 370--377

DOI: 10.1007/s12603-011-0352-6

Journal article

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Impact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.

Pascale Boissonnat, Ségolène Gaillard, Catherine Mercier, Michel Redonnet, Bernard Lelong, Marie-Françoise Mattei...

Trials . 13 ( 1 ) : 231

DOI: 10.1186/1745-6215-13-231

Journal article

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Evaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations

B. Leroy, M. Uhart, P. Maire, Laurent Bourguignon

Journal of Antimicrobial Chemotherapy . 67 : 2207--2212

DOI: 10.1093/jac/dks195

Journal article

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Relationship between benzodiazepines use and falls in the elderly: A multicenter study in three geriatric centers of a university hospital

M. Uhart, E. Odouard, C. Carlier, P. Maire, M. Ducher, Laurent Bourguignon

Annales Pharmaceutiques Françaises . 70 : 46-52

Journal article

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Schwartz Formula: Is One k-Coefficient Adequate for All Children?

V. C. de Souza, Muriel Rabilloud Ferrand, P. Cochat, L. Selistre, A. Hadj-Aissa, Behrouz Kassai Koupai...

PLoS ONE . 7 : e53439

DOI: 10.1371/journal.pone.0053439

Journal article

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Prescriptions analysis by clinical pharmacists in the post-operative period: a 4-year prospective study.

B. Charpiat, Sylvain Goutelle, M. Schoeffler, F. Aubrun, J.-P. Viale, C. Ducerf...

Acta Anaesthesiologica Scandinavica . 56 ( 8 ) : 1047-51

DOI: 10.1111/j.1399-6576.2011.02644.x

Journal article

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New disease gene location and high genetic heterogeneity in idiopathic scoliosis

Patrick Edery, Patricia Margaritte-Jeannin, Bernard Biot, Audrey Labalme, Jean-Claude Bernard, Joelle Chastang...

European Journal of Human Genetics .

DOI: 10.1038/ejhg.2011.31

Journal article

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Version française des questionnaires de dépistage de l'autisme de haut niveau ou du syndrome d'Asperger chez l'adolescent : Quotient du spectre de l'autisme Quotient d'Empathie et Quotient de Systématisation. Protocole et traduction des questionnaires

Sandrine Sonié, Behrouz Kassai, Elodie Pirat, Sandrine Masson, Paul Bain, Janine Robinson...

La Presse medicale . : 1-15

DOI: 10.1016/j.lpm.2010.07.016

Journal article

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Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis

J. Dubourg, E. Javouhey, T. Geeraerts, M. Messerer, Behrouz Kassai

Intensive Care Medicine . -- : 1-10

Journal article

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Growth Hormone to Improve Short Bowel Syndrome Intestinal Autonomy : A Pediatric Randomized Open-Label Clinical Trial

N. Peretti, I. Loras-Duclaux, Behrouz Kassai, L. Restier-Miron, D. Guimber, F. Gottrand...

Journal of Parenteral and Enteral Nutrition . 20 : 1-9

Journal article

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Guideline on the design and conduct of cystic fibrosis clinical trials: The European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN)

K. de Boeck, V. Bulteel, H. Tiddens, T. Wagner, I. Fajac, S. Conway...

Journal of Cystic Fibrosis . 10 : S67-S74

DOI: 10.1016/S1569-1993(11)60010-6

Journal article

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Diagnostic accuracy of ultrasonography of optic nerve sheath diameter for detecting raised intracranial pressure

J. Dubourg, M. Messerer, T. Geeraerts, F. Cour-Andlauer, E. Javouhey, Behrouz Kassai Koupai

Acta Anaesthesiologica Scandinavica . 55 : 899-899

DOI: 10.1111/j.1399-6576.2011.02468.x

Journal article

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51 – Existe-t-il une surmortalité chez les femmes dépistées par mammographie ? Méta-analyse sur la mortalité non liée au cancer du sein

L. Fayolle, F. Gueyffier, S. Erpeldinger

33° Journées de la Société Française de Sénologie et de Pathologie Mammaire (SFSPM), Marseille, 2011. Cancer du sein : surdiagnostic, surtraitement. A la recherche d'un nouvel équilibre . : 339

Conference paper

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Étude coût-efficacité de l'adaptation bayésienne des posologies des aminosides en gériatrie

C. Burgos Leon-Dijan, Laurent Bourguignon, H-M. Späth, Pascal Maire

Pharmacoéconomie . 66 : 445-452

DOI: 10.2515/therapie/2011058

Journal article

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The value of population pharmacokinetics and simulation for postmarketing safety evaluation of dosing guidelines for drugs with a narrow therapeutic index: buflomedil as a case study

Laurent Bourguignon, Michel Ducher, David Matanza, Nathalie Bleyzac, Mathieu Uhart, Emmanuel Odouard...

Fundamental & Clinical Pharmacology . 26 ( 2 ) : 279-285

DOI: 10.1111/j.1472-8206.2011.01000.x

Journal article

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Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions

Michel Tod, Sylvain Goutelle, Fannie Clavel-Grabit, Grégoire Nicolas, Bruno Charpiat

Clinical Pharmacokinetics . 50 ( 8 ) : 519-530

DOI: 10.2165/11592620-000000000-00000

Journal article

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A New Animal Model of Obstructive Sleep Apnea Responding to Continuous Positive Airway Pressure

Pc. Neuzeret, F. Gormand, Philippe Reix, S. Parrot, Jp. Sastre, C. Buda...

Sleep . 34 : 541-548

Journal article

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Intrafamilial transmission of Staphylococcus aureus Panton-Valentine leukocidin responsible for two cases of neonatal necrotizing pneumonia

G. Catho, Y. Gillet, O. Dumitrescu, G. Lina, G. Labbé, G. Bellon...

Archives de Pédiatrie . 18 : 1090-1094

DOI: 10.1016/j.arcped.2011.07.019

Journal article

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Combined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation

V. Cottin, Philippe Reix, C. Khouatra, F. Thivolet-Bejui, D. Feldmann, J. F. Cordier

Thorax . 66 ( 10 ) : 918-9

DOI: 10.1136/thx.2010.151407

Journal article

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Programmed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients

C. Guignant, C. Lepage, X. Huang, H. Kherouf, L. Denis, F. Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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Effect of intensive glucose lowering treatment on all cause mortality cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials

R. Boussageon, T. Bejan-Angoulvant, M. Saadatian-Elahi, S. Lafont, C. Bergeonneau, Behrouz Kassai...

British medical journal . 343 : 1-12

DOI: 10.1136/bmj.d4169

Journal article

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Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.

Caroline Guignant, Alain Lepape, Xin Huang, Hakim Kherouf, Laure Denis, Françoise Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies

I. Marchant, Patrice Nony, Michel Cucherat, J-P. Boissel, S.R. Thomas, T. Bejan-Angoulvant...

PLoS ONE . 6 ( 3 ) : 1-7

DOI: 10.1371/journal.pone.0017508

Journal article

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Probable Drug Interaction Between Intravenous Ciprofloxacin and Mycophenolate Mofetil in a Bone Marrow Transplant Recipient

Sylvain Goutelle, V. Mialou, A. Gouraud, F. Parant, N. Bleyzac

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy . 31(1) : 36-40

Journal article

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Towards personalized medicine: exploring the consequences of the effect model-based approach

Jp. Boissel, R. Kaboul, E. Amsallem, François Gueyffier, M. Haugh, F. H. Boissel

Personalized Medicine . 8 : 581-586

DOI: 10.2217/pme.11.54

Journal article

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Problématique des cibles de pression artérielle

R. Boussageon, T. Bejan-Angoulvant, François Gueyffier

Revue médicale Suisse . : 873

Journal article

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