Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 421 to 450 publications on 613 in total

Exposure to anticholinergic and sedative drugs, risk of falls, and mortality: an elderly inpatient, multicenter cohort

V. Dauphinot, R. Faure, S. Omrani, Sylvain Goutelle, Laurent Bourguignon, P. Krolak-Salmon...

Journal of clinical psychopharmacology . 34 : 565-70

DOI: 10.1097/JCP.0000000000000195

Journal article

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Pharmacokinetic Drug Interaction Between Cyclosporine and Imatinib in Bone Marrow Transplant Children and Model-Based Reappraisal of Imatinib Drug Interaction Profile

Nathalie Bleyzac, K. Kebaili, V. Mialou, Y. Bertrand, Sylvain Goutelle

Therapeutic Drug Monitoring . 36 : 724-729

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Pharmacokinetic drug-drug interaction of calcium channel blockers with cyclosporine in hematopoietic stem cell transplant children

E. Bernard, Sylvain Goutelle, Y. Bertrand, Nathalie Bleyzac

The Annals of Pharmacotherapy . 48 : 1580-4

DOI: 10.1177/1060028014550644

Journal article

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Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate

Kayode Ogungbenro, Leon Aarons, A Bajard, C Ballot, Y Bertrand, F Bretz...

Journal of Pharmacokinetics and Pharmacodynamics . 41 ( 2 ) : 173-185

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Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Groups, Catherine Cornu, Behrouz Kassai...

Journal of pharmacokinetics and pharmacodynamics . 41 : 159-71

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A physiologically based pharmacokinetic model for Valproic acid in adults and children

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Group, Catherine Cornu, Patrice Nony...

European Journal of Pharmaceutical Sciences . 63 : 45-52

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A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Group, Catherine Cornu, Behrouz Kassai...

Pharmaceutical Research . 32 : 144-157

Journal article

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A methodological framework for drug development in rare diseases

Patrice Nony, Polina Kurbatova, Agathe Bajard, Salma Malik, Charlotte Castellan, Sylvie Chabaud...

Orphanet Journal of Rare Diseases . 9 ( 164 ) : 1-10

DOI: 10.1186/s13023-014-0164-y

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Recruitment in pediatric clinical research was influenced by study characteristics and pediatricians' perceptions: a multicenter survey.

Florentia Kaguelidou, Philippe Amiel, Audrey Blachier, Catalina Iliescu, Jean-Christophe Rozé, Michel Tsimaratos...

Journal of Clinical Epidemiology . 66 ( 10 ) : epub ahead of print

DOI: 10.1016/j.jclinepi.2013.04.015

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Experimental designs for small randomised clinical trials: an algorithm for choice.

Catherine Cornu, Behrouz Kassai, Roland Fisch, Catherine Chiron, Corinne Alberti, Renzo Guerrini...

Orphanet Journal of Rare Diseases . 8 ( 1 ) : 48

DOI: 10.1186/1750-1172-8-48

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A revisited strategy for antiepileptic drug development in children: designing an initial exploratory step

C. Chiron, Behrouz Kassai, O. Dulac, Gérard Pons, R. Nabbout

CNS Drugs . 27 : 185-95

DOI: 10.1007/s40263-012-0035-9

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A European approach to clinical investigator training

Jm. Boeynaems, C. Canivet, A. Chan, Mj. Clarke, C. Cornu, E. Daemen...

Frontiers in Pharmacology . 4 : 112

DOI: 10.3389/fphar.2013.00112

Journal article

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L\textquoterighteffet placebo chez l\textquoterightenfant est méconnu et peu étudié

B. Kassai, H. Gheit, R. Boussageon, F. Gueyffier

La Lettre du Pharmacologue . 27 : 17--20

Journal article

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Information et participation active des patients à l\textquoterightaide d\textquoterightune brochure interactive lors de la prescription d\textquoterightantihypertenseurs en soins primaires

M. Keriel-Gascou, A. Badet-Phan, Ma. Le Pogam, S. Figon, L. Letrilliart, F. Gueyffier...

Santé Publique . 25 : 193--201

Journal article

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Physicians' knowledge and practice of lung cancer screening: a cross-sectional survey comparing general practitioners, thoracic oncologists, and pulmonologists in France

S. Couraud, N. Girard, S. Erpeldinger, François Gueyffier, G. Devouassoux, G. Llorca...

Clinical Lung Cancer . 14 : 574-80

DOI: 10.1016/j.cllc.2013.05.003

Journal article

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Biomarker-guided therapies in heart failure: a forum for unified strategies

M. Fiuzat, C. M. O'Connor, François Gueyffier, A. M. Mascette, N. L. Geller, A. Mebazaa...

Journal of Cardiac Failure . 19 : 592-9

DOI: 10.1016/j.cardfail.2013.05.012

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Impaired baroreflex sensitivity and the risks of new-onset ambulatory hypertension, in an elderly population-based study

V. Dauphinot, M. P. Kossovsky, François Gueyffier, V. Pichot, P. Gosse, F. Roche...

International Journal of Cardiology . 168 : 4010-4

DOI: 10.1016/j.ijcard.2013.06.080

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Meta-analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data

Richard Riley, Iram Kauser, Martin Bland, Lutgarde Thijs, Jan Staessen, Jiguang Wang...

Statistics in Medicine . 32 ( 16 ) : 2747-2766

DOI: 10.1002/sim.5726

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Are we using blood pressure-lowering drugs appropriately? Perhaps now is the time for a change

François Gueyffier, J. Wright

Journal of human hypertension . 28 : 68-70

DOI: 10.1038/jhh.2013.79

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Practical application of the charter of pharmaceutical sales visit

B. Leroy, M. Uhart, A. Lajoinie, P. Maire, M. Ducher, Laurent Bourguignon

Annales Pharmaceutiques Françaises . 70 : 348--52

DOI: 10.1016/j.pharma.2012.06.001

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Impact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis

Jc. Lega, P. Mismetti, M. Cucherat, T. Fassier, L. Bertoletti, C. Chapelle...

Journal of Thrombosis and Haemostasis . 98 : 97--102

DOI: 10.1111/jth.12294

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Simulation of human ischemic stroke in realistic 3D geometry

Thierry Dumont, Max Duarte, Stéphane Descombes, Marie-Aimée Dronne, Marc Massot, Violaine Louvet

Communications in Nonlinear Science and Numerical Simulation . 18 ( 6 ) : 1539-1557

DOI: 10.1016/j.cnsns.2012.10.002

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Impact of Genetic Polymorphism on Drug-Drug Interactions Mediated by Cytochromes: A General Approach

M. Tod, C. Nkoud-Mongo, François Gueyffier

AAPS journal . 15 : 1242--1252

DOI: 10.1208/s12248-013-9530-2

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Quantitative Prediction of the Impact of Drug Interactions and Genetic Polymorphisms on Cytochrome P450 2C9 Substrate Exposure

Anne-Charlotte Castellan, M. Tod, François Gueyffier, M. Audars, F. Cambriels, Berouz Kassai...

Clinical Pharmacokinetics . 52 : 199-209

DOI: 10.1007/s40262-013-0031-3

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In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates

Sylvain Goutelle, Laurent Bourguignon, Nathalie Bleyzac, J. Berry, F. Clavel-Grabit, M. Tod

AAPS Journal . 15 : 415-26

DOI: 10.1208/s12248-012-9431-9

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New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare(R) cohort.

Jessica Taytard, Nadia Nathan, Jacques de Blic, Mickael Fayon, Ralph Epaud, Antoine Deschildre...

Orphanet Journal of Rare Diseases . 8 ( 1 ) : 161

DOI: 10.1186/1750-1172-8-161

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Prognostic value of troponins in sepsis: a meta-analysis

F. Bessiere, S. Khenifer, J. Dubourg, I. Durieu, Jean-Christophe Lega

Intensive Care Medicine . 39 : 1181-9

DOI: 10.1007/s00134-013-2902-3

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Revising the ECRIN standard requirements for information technology and data management in clinical trials.

Christian Ohmann, Steve Canham, Catherine Cornu, Jochen Dress, François Gueyffier, Wolfgang Kuchinke...

Trials . 14 ( 1 ) : 97

DOI: 10.1186/1745-6215-14-97

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Pharmacoepidemiology studies: what levels of evidence and how can they be reached?

Maryse Lapeyre-Mestre, Claudine Sapède, Nicholas Moore, Pascal Bilbault, Patrick Blin, Damien Chopy...

Thérapie . 68 ( 4 ) : 241-52

DOI: 10.2515/therapie/2013038

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Pharmacokinetic-pharmacodynamic modeling of unboosted Atazanavir in a cohort of stable HIV-infected patients.

Sylvain Goutelle, Thomas Baudry, Marie-Claude Gagnieu, André Boibieux, Jean-Michel Livrozet, Dominique Peyramond...

Antimicrobial Agents and Chemotherapy . 57 ( 1 ) : 517-23

DOI: 10.1128/AAC.01822-12

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