Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87

Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18

Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83

Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99

Doctorante
autre
Tel: 04 72 44 81 42

Praticien hospitalier
HCL
Tel: 04 72 44 81 42

Professeur d'université - praticien hospitalier émérite
UCBL

Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01

Post-doc
UCBL

Maîtresse de conférences - praticienne hospitalière
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20

Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Doctorante
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 331 to 360 publications on 628 in total
Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.
International Journal of Antimicrobial Agents .
Journal article
see the publicationEfficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials
Diabetes & Metabolism . 43 ( 1 ) : 48 - 58
Journal article
see the publicationNo benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials
PLoS ONE . 12 : e0171168
Journal article
see the publicationPopulation pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen
Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812
DOI: 10.1093/jac/dkx242
Journal article
see the publicationMechanisms of drug-drug interaction between rifampicin and fusidic acid
British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864
DOI: 10.1111/bcp.13277
Journal article
see the publicationA Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics
Clinical Pharmacokinetics . 56 : 435-447
Journal article
see the publicationPrevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months
Drugs & aging . 34 : 545-553
Journal article
see the publicationMathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients
Mathematical Medicine and Biology .
Journal article
see the publicationPhone-based safety monitoring of the first year of baclofen treatment for alcohol use disorder: the baclophone cohort study protocol
Expert Opinion on Drug Safety . 16 ( 2 ) : 125-132
Journal article
see the publicationProactive Regional Pharmacovigilance System Versus National Spontaneous Reporting for Collecting Safety Data on Concerning Off-Label Prescribing Practices: An Example with Baclofen and Alcohol Dependence in France
Drug Safety . 40 : 257-262
Journal article
see the publicationA Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients
PLoS ONE . 11 ( 2 ) : e0149717
Journal article
see the publicationADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate
Epilepsia . 57 : 1069-77
DOI: 10.1111/epi.13420
Journal article
see the publicationSafety study of Ciprofloxacin in newborn mice
Regulatory Toxicology and Pharmacology . 74 : 161-169
Journal article
see the publicationEfficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials
BMC Endocrine Disorders . 16 : 39
Journal article
see the publicationFactors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study
European Journal of Neurology . 24 ( 3 ) : 483-490
DOI: 10.1111/ene.13228
Journal article
see the publicationPharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years
Antimicrobial Agents and Chemotherapy . 60 ( 8 ) : 4563-4567
DOI: 10.1128/AAC.00303-16
Journal article
see the publicationImproved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis
Bone Marrow Transplantation . 51 ( 5 ) : 698-704
DOI: 10.1038/bmt.2015.350
Journal article
see the publicationPharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation
Biology of Blood and Marrow Transplantation . 22 ( 1 ) : 185
Journal article
see the publicationOral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period
International Journal of Pharmaceutics . 500 : 336-44
Journal article
see the publicationStereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis . 131 : 233-245
Journal article
see the publicationSevere Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)
Chest . 150 ( 3 ) : E65-E71
Journal article
see the publicationModerate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients
Prostaglandins, Leukotrienes and Essential Fatty Acids . 115 : 41 - 47
Journal article
see the publicationEfficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
Journal of Allergy and Clinical Immunology . 138 ( 6 ) : 1752-1755
Journal article
see the publicationIs the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?
Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationPartial validation of a French version of the ADHD-rating scale IV on a French population of children with ADHD and epilepsy. Factorial structure, reliability, and responsiveness
Epilepsy & Behavior . 58 : 1-6
Journal article
see the publicationGrowth curves for congenital adrenal hyperplasia from a national retrospective cohort
Journal of pediatric endocrinology & metabolism . 29 : 1379-1388
Journal article
see the publicationQuality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
Journal article
see the publicationRéférentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Thérapie .
Journal article
see the publication
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