Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 331 to 360 publications on 632 in total

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

Journal article

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

Journal article

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Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?

C. Mainguy, G. Bellon, V. Delaup, T. Ginoux, B. Kassai-Koupai, S. Mazur...

Journal of pediatric endocrinology & metabolism . 30 : 27-35

DOI: 10.1515/jpem-2016-0184

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Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Céline Pouzot Pouzot-Névoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz...

International Journal of Antimicrobial Agents .

DOI: 10.1016/j.ijantimicag.2017.03.029

Journal article

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Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes & Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

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No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

Journal article

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

Journal article

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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 56 : 435-447

DOI: 10.1007/s40262-016-0448-6

Journal article

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. de La Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

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Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Nathalie Eymard, Vitaly Volpert, Polina Kurbatova, Nikolai Bessonov, Kayode Ogungbenro, Leon Aarons...

Mathematical Medicine and Biology .

DOI: 10.1093/imammb/dqw019

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Phone-based safety monitoring of the first year of baclofen treatment for alcohol use disorder: the baclophone cohort study protocol

Benjamin Rolland, Marine Auffret, Julien Labreuche, Maryse Lapeyre-Mestre, Malek Dib, Aomar Kemkem...

Expert Opinion on Drug Safety . 16 ( 2 ) : 125-132

DOI: 10.1080/14740338.2017.1270939

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Proactive Regional Pharmacovigilance System Versus National Spontaneous Reporting for Collecting Safety Data on Concerning Off-Label Prescribing Practices: An Example with Baclofen and Alcohol Dependence in France

Marine Auffret, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Olivier Cottencin, Regis Bordet...

Drug Safety . 40 : 257-262

DOI: 10.1007/s40264-016-0489-7

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A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients

Aurore Curie, Amandine Brun, Anne Cheylus, Anne Reboul, Tatjana Nazir, Gérald Bussy...

PLoS ONE . 11 ( 2 ) : e0149717

DOI: 10.1371/journal.pone.0149717

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ADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate

S. Rheims, V. Herbillon, N. Villeneuve, S. Auvin, S. Napuri, C. Cances...

Epilepsia . 57 : 1069-77

DOI: 10.1111/epi.13420

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Safety study of Ciprofloxacin in newborn mice

T. Bourgeois, Al. Delezoide, W. Zhao, F. Guimiot, H. Adle-Biassette, E. Durand...

Regulatory Toxicology and Pharmacology . 74 : 161-169

DOI: 10.1016/j.yrtph.2015.11.002

Journal article

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Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials

S. Erpeldinger, M. B. Rehman, C. Berkhout, C. Pigache, Y. Zerbib, F. Regnault...

BMC Endocrine Disorders . 16 : 39

DOI: 10.1186/s12902-016-0120-z

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Factors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study

V. Dauphinot, R. Faure, L. Bourguignon, Sylvain Goutelle, P. Krolak-Salmon, C. Mouchoux

European Journal of Neurology . 24 ( 3 ) : 483-490

DOI: 10.1111/ene.13228

Journal article

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Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years

Laurent Bourguignon, Yoann Cazaubon, Guillaume Debeurme, Constance Loue, Michel Ducher, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 60 ( 8 ) : 4563-4567

DOI: 10.1128/AAC.00303-16

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Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis

N Bleyzac, D Cuzzubbo, C Rénard, N Garnier, V Dubois, C Domenech...

Bone Marrow Transplantation . 51 ( 5 ) : 698-704

DOI: 10.1038/bmt.2015.350

Journal article

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Pharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation

Michael Philippe, Nathalie Bleyzac, Sylvain Goutelle

Biology of Blood and Marrow Transplantation . 22 ( 1 ) : 185

DOI: 10.1016/j.bbmt.2015.09.022

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Oral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period

A. Lajoinie, E. Henin, K.A. Nguyen, S. Malik, Y. Mimouni, J.M. Sapori...

International Journal of Pharmaceutics . 500 : 336-44

DOI: 10.1016/j.ijpharm.2016.01.048

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Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry

Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka...

Journal of Pharmaceutical and Biomedical Analysis . 131 : 233-245

DOI: 10.1016/j.jpba.2016.08.014

Journal article

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Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)

Cécile Picard, Guillaume Thouvenin, Caroline Kannengiesser, Jean-Christophe Dubus, Nadia Jeremiah, Frédéric Rieux-Laucat...

Chest . 150 ( 3 ) : E65-E71

DOI: 10.1016/j.chest.2016.02.682

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Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients

Evelyne Véricel, Stéphane Mazur, Romain Colas, Véronique Delaup, Catherine Calzada, Philippe Reix...

Prostaglandins, Leukotrienes and Essential Fatty Acids . 115 : 41 - 47

DOI: 10.1016/j.plefa.2016.10.008

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Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

Marie-Louise Frémond, Mathieu Paul Rodero, Nadia Jeremiah, Alexandre Belot, Eric Jeziorski, Darragh Duffy...

Journal of Allergy and Clinical Immunology . 138 ( 6 ) : 1752-1755

DOI: 10.1016/j.jaci.2016.07.015

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Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?

Stefan Matecki, Lisa Kent, Kris de Boeck, Muriel Le Bourgeois, Stefan Zielen, Cesare Braggion...

Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20

DOI: 10.1016/j.jcf.2015.03.015

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Heterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study

Cécile Picard, Thierry Vincent, Jean-Christophe Lega, Sophie Hue, Françoise Fortenfant, Daniel Lakomy...

Immunologic Research . 64 ( 3 ) : 677-686

DOI: 10.1007/s12026-015-8774-6

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Tocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children

Natalia Cabrera, Agnes Duquesne, Marine Desjonquères, Jean-Paul Larbre, Jean-Christophe Lega, Nicole Fabien...

RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271

DOI: 10.1136/rmdopen-2016-000271

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