Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 331 to 360 publications on 613 in total

Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials

S. Erpeldinger, M. B. Rehman, C. Berkhout, C. Pigache, Y. Zerbib, F. Regnault...

BMC Endocrine Disorders . 16 : 39

DOI: 10.1186/s12902-016-0120-z

Journal article

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Factors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study

V. Dauphinot, R. Faure, L. Bourguignon, Sylvain Goutelle, P. Krolak-Salmon, C. Mouchoux

European Journal of Neurology . 24 ( 3 ) : 483-490

DOI: 10.1111/ene.13228

Journal article

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Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years

Laurent Bourguignon, Yoann Cazaubon, Guillaume Debeurme, Constance Loue, Michel Ducher, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 60 ( 8 ) : 4563-4567

DOI: 10.1128/AAC.00303-16

Journal article

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Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis

N Bleyzac, D Cuzzubbo, C Rénard, N Garnier, V Dubois, C Domenech...

Bone Marrow Transplantation . 51 ( 5 ) : 698-704

DOI: 10.1038/bmt.2015.350

Journal article

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Pharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation

Michael Philippe, Nathalie Bleyzac, Sylvain Goutelle

Biology of Blood and Marrow Transplantation . 22 ( 1 ) : 185

DOI: 10.1016/j.bbmt.2015.09.022

Journal article

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Oral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period

A. Lajoinie, E. Henin, K.A. Nguyen, S. Malik, Y. Mimouni, J.M. Sapori...

International Journal of Pharmaceutics . 500 : 336-44

DOI: 10.1016/j.ijpharm.2016.01.048

Journal article

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Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry

Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka...

Journal of Pharmaceutical and Biomedical Analysis . 131 : 233-245

DOI: 10.1016/j.jpba.2016.08.014

Journal article

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Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)

Cécile Picard, Guillaume Thouvenin, Caroline Kannengiesser, Jean-Christophe Dubus, Nadia Jeremiah, Frédéric Rieux-Laucat...

Chest . 150 ( 3 ) : E65-E71

DOI: 10.1016/j.chest.2016.02.682

Journal article

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Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients

Evelyne Véricel, Stéphane Mazur, Romain Colas, Véronique Delaup, Catherine Calzada, Philippe Reix...

Prostaglandins, Leukotrienes and Essential Fatty Acids . 115 : 41 - 47

DOI: 10.1016/j.plefa.2016.10.008

Journal article

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Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

Marie-Louise Frémond, Mathieu Paul Rodero, Nadia Jeremiah, Alexandre Belot, Eric Jeziorski, Darragh Duffy...

Journal of Allergy and Clinical Immunology . 138 ( 6 ) : 1752-1755

DOI: 10.1016/j.jaci.2016.07.015

Journal article

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Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?

Stefan Matecki, Lisa Kent, Kris de Boeck, Muriel Le Bourgeois, Stefan Zielen, Cesare Braggion...

Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20

DOI: 10.1016/j.jcf.2015.03.015

Journal article

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Heterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study

Cécile Picard, Thierry Vincent, Jean-Christophe Lega, Sophie Hue, Françoise Fortenfant, Daniel Lakomy...

Immunologic Research . 64 ( 3 ) : 677-686

DOI: 10.1007/s12026-015-8774-6

Journal article

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Tocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children

Natalia Cabrera, Agnes Duquesne, Marine Desjonquères, Jean-Paul Larbre, Jean-Christophe Lega, Nicole Fabien...

RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271

DOI: 10.1136/rmdopen-2016-000271

Journal article

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Partial validation of a French version of the ADHD-rating scale IV on a French population of children with ADHD and epilepsy. Factorial structure, reliability, and responsiveness

Catherine Mercier, S. Roche, Sophie Gaillard, Behrouz Kassai, A. Arzimanoglou, V. Herbillon...

Epilepsy & Behavior . 58 : 1-6

DOI: 10.1016/j.yebeh.2016.02.016

Journal article

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Growth curves for congenital adrenal hyperplasia from a national retrospective cohort

P. Bretones, B. Riche, E. Pichot, M. David, Pascal Roy, V. Tardy...

Journal of pediatric endocrinology & metabolism . 29 : 1379-1388

DOI: 10.1515/jpem-2016-0156

Journal article

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Quality of qualitative studies centred on patients in family practice: a systematic review

Benedicte Eschalier, Stéphane Descamps, Bruno Pereira, Hélène Vaillant-Roussel, Guillaume Girard, Stéphane Boisgard...

Family Practice . 33 ( 6 ) : 580 - 587

DOI: 10.1093/fampra/cmw095

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Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Thérapie .

DOI: 10.2515/therapie/2015042

Journal article

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Quantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers

L. Gabriel, M. Tod, Sylvain Goutelle

Clinical Pharmacokinetics . 55 : 977-990

DOI: 10.1007/s40262-016-0371-x

Journal article

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Introduction of a paediatric anaesthesia comic information leaflet reduced preoperative anxiety in children

B. Kassai, Muriel Rabilloud, E. Dantony, S. Grousson, O. Revol, S. Malik...

British Journal of Anaesthesia . 117 : 95-102

DOI: 10.1093/bja/aew154

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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

M. Neely, M. Philippe, T. Rushing, X. Fu, M. van Guilder, D. Bayard...

Therapeutic Drug Monitoring . 38 : 332-342

DOI: 10.1097/FTD.0000000000000276

Journal article

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Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

M. Philippe, Sylvain Goutelle, J. Guitton, X. Fonrose, C. Bergeron, Pascal Girard...

Bone Marrow Transplantation . 51 : 72-78

DOI: 10.1038/bmt.2015.218

Journal article

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Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

L. Lalande, Laurent Bourguignon, P. Maire, Sylvain Goutelle

Journal of Theoretical Biology . 399 : 43-52

DOI: 10.1016/j.jtbi.2016.03.038

Journal article

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Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

G. Taverny, Y. Mimouni, A. Ledigarcher, P. Chevalier, L. Thijs, J.M. Wright...

Cochrane database of systematic reviews (Online) . 3 : CD011745

DOI: 10.1002/14651858.CD011745.pub2

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One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun...

Trials . 17 ( 1 ) : 404

DOI: 10.1186/s13063-016-1484-0

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Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

H.-H. Le, C. El-Khatib, M. Mombled, F. Guitarian, M. Al-Gobari, M. Fall...

PLoS ONE . 11 : e0145958

DOI: 10.1371/journal.pone.0145958

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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, Florence Ader...

Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151

DOI: 10.1128/AAC.02597-15

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Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

M. Tod, P.B. Pierrillas, Laurent Bourguignon, Sylvain Goutelle

International Journal of Pharmacokinetics . : 1-10

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Metformin as firstline treatment for type 2 diabetes: are we sure?

R. Boussageon, François Gueyffier, Catherine Cornu

BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748

DOI: 10.1136/bmj.h6748

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Baclofen for alcohol dependence: relationships between baclofen and alcohol dosing and the occurrence of major sedation

Benjamin Rolland, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Sophie Gautier, Marine Auffret...

European Neuropsychopharmacology . 25 : 1631-1636

DOI: 10.1016/j.euroneuro.2015.05.008

Journal article

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Des ruptures de stock aux conséquences parfois graves : l’exemple de la phénytoïne, à propos de 7 cas

Marine Auffret, Louise Tyvaert, Marie-Laure Laroche, Bertrand Godet, Roland Peyron, Claire Guy...

Thérapie . 70 ( 4 ) : 377-380

DOI: 10.2515/therapie/2015018

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