Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Stagiaire
HCL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Maîtresse de conférences - praticienne hospitalière
UCBL
Stagiaire
HCL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 1 to 30 publications on 256 in total
Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis
Journal of Antimicrobial Chemotherapy .
DOI: 10.1093/jac/dkae026
Journal article
see the publicationTheratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription
European Respiratory Journal . 62 ( 4 ) : 2300110
Journal article
see the publicationLung Transplantation under a Janus Kinase Inhibitor in Three Patients with SAVI Syndrome
Journal of Clinical Immunology . 43 ( 8 ) : 2156-2164
Journal article
see the publicationMethotrexate does not affect lung function in children with juvenile idiopathic arthritis
Pediatric Pulmonology . 58 ( 12 ) : 3630-3636
DOI: 10.1002/ppul.26681
Journal article
see the publicationClinical problems in rare interstitial lung diseases
European Respiratory Society .
Poster
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationPreuves de bénéfice et décision thérapeutique : enquête auprès de médecins généralistes sur la prescription d’hydroxychloroquine pour traiter la Covid-19
Exercer . 34 ( 195 ) : 298-304
Journal article
see the publicationDefining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study
Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769
DOI: 10.1093/jac/dkad300
Journal article
see the publicationA Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies
ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046
Conference paper
see the publicationTherapeutic Drug Monitoring of Antibiotic Drugs in Patients Receiving Continuous Renal Replacement Therapy or Intermittent Hemodialysis: A Critical Review
Therapeutic Drug Monitoring . 44 ( 1 ) : 86-102
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationDaptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
Clinical Pharmacokinetics . 61 ( 10 ) : 1443-1456
Journal article
see the publicationImplementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis
Pharmaceutics . 14 ( 8 ) : 1750
Journal article
see the publicationSeventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm
Open Forum Infectious Diseases . 9 ( 11 ) : ofac577
DOI: 10.1093/ofid/ofac577
Journal article
see the publicationPredicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France
Vaccines . 10 ( 12 ) : 2033
Journal article
see the publicationAn Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
Pharmaceutics . 14 ( 10 ) : 2177
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics .
DOI: 10.1111/tan.14852
Journal article
see the publicationSelected and simplified FDI criteria for assessment of restorations
Journal of Dentistry . 122 : 104109
Journal article
see the publicationHow do they add up? The interaction between the placebo and treatment effect: A systematic review
British Journal of Clinical Pharmacology . 88 ( 8 ) : 3638-3656
DOI: 10.1111/bcp.15345
Journal article
see the publicationPlace of a new radiological index in predicting pulp exposure before intervention for deep carious lesions
Oral Radiology . 38 ( 1 ) : 89-98
Journal article
see the publicationUsing chest CT scan and unsupervised machine learning for predicting and evaluating response to lumacaftor-ivacaftor in people with cystic fibrosis
European Respiratory Journal . : 2101344
Journal article
see the publicationDiffuse alveolar haemorrhage in children: an international multicentre study
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationReal-world assessment of LCI following lumacaftor-ivacaftor initiation in adolescents and adults with cystic fibrosis
Journal of Cystic Fibrosis .
Journal article
see the publicationChest physiotherapy enhances detection of Pseudomonas aeruginosa in nonexpectorating children with cystic fibrosis
ERJ Open Research . 7 ( 1 ) : 00513-2020
Journal article
see the publicationFactors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort
Journal of Allergy and Clinical Immunology: In Practice . 9 ( 5 ) : 1969-1979
Journal article
see the publication
You also, comment on this article