Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 91 to 120 publications on 626 in total

Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

see the publication

The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

see the publication

Quelle place pour l’automatisation intelligente et l’intelligence artificielle pour préserver et renforcer l’expertise en vigilance devant l’augmentation des déclarations ?

Antoine Pariente, Joelle Micallef, Amir Lahouegue, Mathieu Molimard, Marine Auffret, Laurent Chouchana...

Therapies . 78 ( 1 ) : 115-129

DOI: 10.1016/j.therap.2022.11.003

Journal article

see the publication

Estimating individualized treatment effects using individual participant data meta-analysis

Florie Brion Bouvier, Anna Chaimani, François Gueyffier, Guillaume Grenet, Raphaël Porcher

Preprint

see the publication

A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial

Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Alloh, Catherine Cornu...

BMC Cancer . 22 ( 1 ) : 575

DOI: 10.1186/s12885-022-09564-7

Journal article

see the publication

Machine-Learning Exploration of Exposure-Effect Relationships of Cisplatin in Head and Neck Cancer Patients

Céleste Cauvin, Laurent Bourguignon, Laure Carriat, Abel Mence, Pauline Ghipponi, Sébastien Salas...

Pharmaceutics . 14 ( 11 ) : 2509

DOI: 10.3390/pharmaceutics14112509

Journal article

see the publication

SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

see the publication

Indirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis

Sabine Mainbourg, Axel Tabary, Michel Cucherat, François Gueyffier, Hervé Lobbes, Marie Aussedat...

Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835

DOI: 10.1016/j.mayocp.2022.03.010

Journal article

see the publication

Screening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?

Delphine Thiolliere, Brahim Harbaoui, Claire Falandry, Marc Bonnefoy, Jean-Christophe Lega, Pierre Lantelme...

Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801

DOI: 10.11909/j.issn.1671-5411.2022.11.005

Journal article

see the publication

Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

see the publication

Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

Maxime Auroux, Benjamin Laurent, Baptiste Coste, Emmanuel Massy, Alexandre Mercier, Isabelle Durieu...

Revue du Rhumatisme . 89 ( 5 ) : 435-446

DOI: 10.1016/j.rhum.2022.07.002

Journal article

see the publication

Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

see the publication

Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Élodie Tremblay, Camille Gosselin, Vicky Mai, Annie Lajoie, Roubi Kilo, Jason Weatherald...

Circulation . 146 ( 8 ) : 597-612

DOI: 10.1161/CIRCULATIONAHA.121.058635

Journal article

see the publication

Effective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders

Julien Rossignol, Amani Ouedrani, Cristina Bulai Livideanu, Stéphane Barete, Louis Terriou, David Launay...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 5 ) : 1356-1364.e2

DOI: 10.1016/j.jaip.2021.12.038

Journal article

see the publication

Nécessité d’améliorer nos connaissances sur les pneumopathies interstitielles diffuses associées aux connectivites

Vincent Cottin, Jean-Christophe Lega, Fabienne Coury, Mouhamad Nasser

Revue du Rhumatisme .

DOI: 10.1016/j.rhum.2022.03.006

Journal article

see the publication

Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis

C. Mettler, Ca. Durel, P. Guilpain, B. Bonnotte, F. Cohen-Aubart, M. Hamidou...

European Journal of Internal Medicine . 96 : 97-101

DOI: 10.1016/j.ejim.2021.10.028

Journal article

see the publication

VEXAS syndrome-related AA amyloidosis: a case report

Romain Euvrard, Thomas Fournier, Dana Georgescu, Estelle Bourbon, Pierre Sujobert, Jean Christophe Lega...

Rheumatology . 61 ( 1 ) : e15-e16

DOI: 10.1093/rheumatology/keab683

Journal article

see the publication

Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis

Marie Aussedat, Hervé Lobbes, Maxime Samson, Romain Euvrard, Jean-Christophe Lega, Sabine Mainbourg

Autoimmunity Reviews . 21 ( 1 ) : 102930

DOI: 10.1016/j.autrev.2021.102930

Journal article

see the publication

Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients

Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat...

Arthritis Research and Therapy . 24 ( 1 ) : 167

DOI: 10.1186/s13075-022-02857-z

Journal article

see the publication

The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

see the publication

Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

see the publication

Infection Risk in Patients with Dermatomyositis Associated with Anti-MDA5 Antibodies: A Historical Cohort Study

Anne-Claire Billet, Thomas Barba, Frédéric Coutant, Nicole Fabien, Laurent Perard, Pascal Sève...

Biomedicines . 10 ( 12 ) : 3176

DOI: 10.3390/biomedicines10123176

Journal article

see the publication

Human Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination

Emmanuelle David, Pascal Roy, Alexandre Belot, Pierre Quartier, Brigitte Bader-Meunier, Florence Aeschlimann...

Journal of Clinical Medicine . 11 ( 14 ) : 4137

DOI: 10.3390/jcm11144137

Journal article

see the publication

A call for evidence in connective tissue diseases-associated interstitial lung disease

Vincent Cottin, Jean-Christophe Lega, Fabienne Coury, Mouhamad Nasser

Joint Bone Spine . 89 ( 1 ) : 105274

DOI: 10.1016/j.jbspin.2021.105274

Journal article

see the publication

Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study

S. Bally, J. Cottin, M. C. Gagnieu, J. C. Lega, C. Verstuyft, S. Rheims...

PLoS ONE . 17 ( 12 ) : e0278839

DOI: 10.1371/journal.pone.0278839

Journal article

see the publication

Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics

Mohammad Alshaer, Sylvain Goutelle, Barbara Santevecchi, Bethany Shoulders, Veena Venugopalan, Kartikeya Cherabuddi...

Antimicrobial Agents and Chemotherapy . 66 ( 2 ) : e0204621

DOI: 10.1128/AAC.02046-21

Journal article

see the publication

Amikacin in emergency surgery: How to dose it optimally?

Sylvain Goutelle, Guérin Fritsch, Marie Leroy, Catherine Piron, Camille Salvez, Pascal Incagnoli...

Anaesthesia Critical Care & Pain Medicine . 41 ( 1 ) : 100990

DOI: 10.1016/j.accpm.2021.100990

Journal article

see the publication

Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children

Sylvain Goutelle, Yann Thoma, Roxane Buffet, Michael Philippe, Thierry Buclin, Monia Guidi...

Pharmaceutics . 14 ( 10 ) : 2107

DOI: 10.3390/pharmaceutics14102107

Journal article

see the publication

Pharmacokinetic/Pharmacodynamic Simulations of Cost-Effective Dosage Regimens of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Patients with Renal Impairment

Lucile Dheyriat, Laurent Bourguignon, Thomas Perpoint, Tristan Ferry, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 66 ( 3 ) : e0210421

DOI: 10.1128/AAC.02104-21

Journal article

see the publication

Implementation assessment of a patient personalized clinical pharmacy programme (5P project) into orthogeriatric care pathway

Julie Martin, Marine Barral, Audrey Janoly Dumenil, Emmanuelle Carre, Nicolas Poletto, Sylvain Goutelle...

Journal of Clinical Pharmacy and Therapeutics . 47 ( 7 ) : 956-963

DOI: 10.1111/jcpt.13627

Journal article

see the publication

You also, comment on this article

Choose an avatar
(Will not be posted on the site)
(Will not be posted on the site)