Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 31 to 60 publications on 628 in total

RPEM : Randomized Monte Carlo parametric expectation maximization algorithm

Rong Chen, Alan Schumitzky, Alona Kryshchenko, Keith Nieforth, Michael Tomashevskiy, Shuhua Hu...

CPT: Pharmacometrics and Systems Pharmacology . 13 ( 5 ) : 759-780

DOI: 10.1002/psp4.13113

Journal article

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What are the available online resources targeting psychosocial burden among stroke survivors and their informal caregivers: A scoping review

Marion Delvallée, Romain Garreau, Anne Termoz, Pierre-Marie Ploteau, Laurent Derex, Anne-Marie Schott...

Digital Health . 10

DOI: 10.1177/20552076241240895

Journal article

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Expositions accidentelles à des toxiques chez les enfants - Étude des données de plusieurs sources de recours aux soins entre 2014 et 2020

Christine Tournoud, Ramy Azzouz, Nathalie Beltzer, David Boels, Isabelle Claudet, Luc De Haro...

: 233 p.

Report

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Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data

Elham Jaberi, Inesse Boussaha, Xavier Dode, Guillaume Grenet, Behrouz Kassai, Kim An Nguyen

Healthcare . 12 ( 2 ) : 208

DOI: 10.3390/HEALTHCARE12020208

Journal article

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Exposure to ammonia solution due to substance use: a retrospective study from the French poison centres database (2009–2018)

Aurore Czerwiec, Cecile Chevallier, Guillaume Grenet, Anne-Marie Patat, Sander de Souza, Jeanne Lichtfouse...

Clinical Toxicology . : 1-5

DOI: 10.1080/15563650.2024.2313088

Journal article

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Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis

Abdelwahab Boulekbache, Fanny Maldonado, Raphael Kavafian, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle...

Journal of Antimicrobial Chemotherapy .

DOI: 10.1093/jac/dkae026

Journal article

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Transposable element expression with variation in sex chromosome number: insights into a toxic Y effect on human longevity

Jordan Teoli, Miriam Merenciano, Marie Fablet, Anamaria Necsulea, Daniel Siqueira-De-Oliveira, Alessandro Brandulas-Cammarata...

Peer Community In Genomics .

DOI: 10.1101/2023.08.03.550779

Journal article

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Agent-based models to simulate the COVID-19 epidemic: Understanding the contributions of the determinants of disease spread

Simon Pageaud, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe, Nicolas Leboisne, Catherine Pothier...

44th Conference of the International Society for Clinical Biostatistics (ISCB44) .

Poster

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Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants

William Muller, Shabir Madhi, Beatriz Seoane Nuñez, Manuel Baca Cots, Miroslava Bosheva, Ron Dagan...

New England Journal of Medicine . 388 ( 16 ) : 1533-1534

DOI: 10.1056/NEJMc2214773

Journal article

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Nirsevimab for Prevention of Hospitalizations Due to RSV in Infants

Simon Drysdale, Katrina Cathie, Florence Flamein, Markus Knuf, Andrea Collins, Helen Hill...

New England Journal of Medicine . 389 ( 26 ) : 2425-2435

DOI: 10.1056/NEJMoa2309189

Journal article

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Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

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Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahévas, Jean-François Viallard, Thibault Comont, Stéphane Chèze...

Blood . 142 ( 12 ) : 1099-1101

DOI: 10.1182/blood.2023020311

Journal article

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Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

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Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Pierre-Yves Meunier, Camille Raynaud, Emmanuelle Guimaraes, François Gueyffier, Laurent Letrilliart

Journal of Critical Care . 78 ( 1 ) : 154330

DOI: 10.1370/afm.2908

Journal article

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[Does aspirin have a place in primary cardiovascular prevention by the polypill ? Simulation study on a realistic virtual population].

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

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Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Therapies . 78 ( 5 ) : S11-S18

DOI: 10.2515/therapie/2015042

Journal article

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Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

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Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care

Constanza Serón, Pablo Olivero, Nicolás Flores, Benjamín Cruzat, Francisca Ahumada, François Gueyffier...

Frontiers in Public Health . 11 ( 1 ) : 1270557

DOI: 10.3389/fpubh.2023.1270557

Journal article

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Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

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Project Rebuild the Evidence Base (REB): a method to interpret randomised clinical trials and their meta-analysis to present solid benefit-risk assessments to patients

Rémy Boussageon, Clara Blanchard, Elodie Charuel, Thibault Menini, Bruno Pereira, Florian Naudet...

Therapies . 78 ( 4 ) : 353-365

DOI: 10.1016/j.therap.2022.10.008

Journal article

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Editorial: New insights into caring for pediatric patients with cystic fibrosis

Stephanie Bui, Laurence Delhaes, Gael Dournes, Philippe Reix, Michael John Fayon

Frontiers in Pediatrics . 11

DOI: 10.3389/fped.2023.1243496

Journal article

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L’aspirine a-t-elle une place dans la prévention cardiovasculaire primaire par la polypill ? Étude de simulation sur une population virtuelle réaliste

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

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Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis

Romain Euvrard, Marie Robert, Sabine Mainbourg, Stéphane Dalle, Jean‐christophe Lega

Fundamental & Clinical Pharmacology . 38 ( 2 ) : 369-379

DOI: 10.1111/fcp.12966

Journal article

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Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

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Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

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Incidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observatio

Melanie Aureal, Milene Seauve, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

RMD Open . 9 ( 3 ) : e003064

DOI: 10.1136/rmdopen-2023-003064

Journal article

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Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

see the publication

Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents.

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahevas, Jean-François Viallard, Thibault Comont, Stephane Cheze...

Blood .

DOI: 10.1182/blood.2023020311

Journal article

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Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy

Vicky Mai, Camille Gosselin, Élodie Tremblay, Gabrielle Rompré, Annie Christine Lajoie, Jason Weatherald...

Thorax . 78 ( 7 ) : 721-725

DOI: 10.1136/thorax-2022-219490

Journal article

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