Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 61 to 90 publications on 170 in total

Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

Journal article

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Sex gap in aging and longevity: can sex chromosomes play a role?

Gabriel A.B. Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier...

Biology of Sex Differences . 9 ( 1 ) : 1-14

DOI: 10.1186/s13293-018-0181-y

Journal article

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A sudden death risk score specifically for hypertension

Hai-Ha Le, Fabien Subtil, Marc Cerou, Ivanny Marchant, Muaamar Al-Gobari, Mor Fall...

Journal of Hypertension . 35 ( 11 ) : 2178-2184

DOI: 10.1097/HJH.0000000000001451

Journal article

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Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, A. Metge...

Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264

DOI: 10.1111/fcp.12263

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Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

Aurélien Hugues, Julie Di Marco, Perrine Janiaud, Y Xue, Jennifer Pires, Hooman Khademi...

BMJ Open . 7 ( 1 ) : e013348

DOI: 10.1136/bmjopen-2016-013348

Journal article

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Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier

Thérapie . 72 ( 5 ) : 609 - 613

DOI: 10.1016/j.therap.2017.02.004

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No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

Journal article

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Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes & Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

Journal article

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Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials

S. Erpeldinger, M. B. Rehman, C. Berkhout, C. Pigache, Y. Zerbib, F. Regnault...

BMC Endocrine Disorders . 16 : 39

DOI: 10.1186/s12902-016-0120-z

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Quality of qualitative studies centred on patients in family practice: a systematic review

Benedicte Eschalier, Stéphane Descamps, Bruno Pereira, Hélène Vaillant-Roussel, Guillaume Girard, Stéphane Boisgard...

Family Practice . 33 ( 6 ) : 580 - 587

DOI: 10.1093/fampra/cmw095

Journal article

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Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Thérapie .

DOI: 10.2515/therapie/2015042

Journal article

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Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

G. Taverny, Y. Mimouni, A. Ledigarcher, P. Chevalier, L. Thijs, J.M. Wright...

Cochrane database of systematic reviews (Online) . 3 : CD011745

DOI: 10.1002/14651858.CD011745.pub2

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One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun...

Trials . 17 ( 1 ) : 404

DOI: 10.1186/s13063-016-1484-0

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Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

H.-H. Le, C. El-Khatib, M. Mombled, F. Guitarian, M. Al-Gobari, M. Fall...

PLoS ONE . 11 : e0145958

DOI: 10.1371/journal.pone.0145958

Journal article

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Metformin as firstline treatment for type 2 diabetes: are we sure?

R. Boussageon, François Gueyffier, Catherine Cornu

BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748

DOI: 10.1136/bmj.h6748

Journal article

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Is HbA a valid surrogate for macrovascular and microvascular complications in type 2 diabetes?

T. Bejan-Angoulvant, Catherine Cornu, P. Archambault, B. Tudrej, P. Audier, Y. Brabant...

Diabetes & Metabolism . 41 : 195-201

Journal article

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Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial

F. Gueyffier, F. Subtil, T. Bejan-Angoulvant, Y. Zerbib, J. P. Baguet, J. M. Boivin...

Journal of human hypertension . 29 ( 1 ) : 22-27

DOI: 10.1038/jhh.2014.29

Journal article

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Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

Journal article

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Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Perrine Janiaud, A. Lajoinie, F. Cour-Andlauer, Catherine Cornu, P. Cochat, Michel Cucherat...

Journal of Clinical Epidemiology . 68 : 1221-1231

Journal article

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Is legacy a myth or a reality? We should know, and we do not

F. Gueyffier, Michel Cucherat

Journal of Hypertension . 33 : 2207-9

Journal article

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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

I. Marchant, Jp. Boissel, Patrice Nony, F. Gueyffier

PLoS ONE . 10 ( 11 ) : e0140793

DOI: 10.1371/journal.pone.0140793

Journal article

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Improving risk prediction performance for a better guidelines application

I. Marchant, T. Bejan-Angoulvant, Hh. Le, François Gueyffier

Journal of Hypertension . 32 : 1192-1193

Journal article

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Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population

R. Kahoul, François Gueyffier, E. Amsallem, M. Haugh, I. Marchant, F. H. Boissel...

Journal of the Royal Society Interface . 11 ( 100 ) : 20140867

DOI: 10.1098/rsif.2014.0867

Journal article

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The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial

Laurence Lion-François, François Gueyffier, Catherine Mercier, Daniel Gérard, Vania Herbillon, Isabelle Kemlin...

Orphanet Journal of Rare Diseases . 9 : 142

DOI: 10.1186/s13023-014-0142-4

Journal article

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Effects of pharmacological treatments on micro- and macrovascular complications of type 2 diabetes: What is the level of evidence?

R. Boussageon, François Gueyffier, Catherine Cornu

Diabetes & Metabolism . 40 : 169-75

DOI: 10.1016/j.diabet.2013.12.010

Journal article

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Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease

S. Gaillard, S. Dupuis-Girod, F. Boutitie, S. Riviere, S. Moriniere, P. Y. Hatron...

Journal of Thrombosis and Haemostasis . 12 : 1494-502

DOI: 10.1111/jth.12654

Journal article

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Impact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis

Catherine Cornu, C. Dufays, Ségolène Gaillard, François Gueyffier, M. Redonnet, Laurent Sebbag...

British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32

DOI: 10.1111/bcp.12289

Journal article

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Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial.

Gueyffier F., Subtil F., Bejan-Angoulvant T., Yves Zerbib, Baguet Jp, Boivin Jm...

Journal of Human Hypertension . : doi: 10.1038/jhh.2014.29

Journal article

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Cardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis

M. Thulliez, D. Angoulvant, M. L. Le Lez, Annie-Pierre Jonville-Bera, P. J. Pisella, François Gueyffier...

JAMA Ophthalmology . 132 ( 11 ) : 1317-26

DOI: 10.1001/jamaophthalmol.2014.2333

Journal article

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Guidelines for Managing High Blood Pressure

Dk. Cundiff, François Gueyffier, Jm. Wright

Journal of the American Medical Association . 312 ( 3 ) : 293-294

DOI: 10.1001/jama.2014.6590

Journal article

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