Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 31 to 60 publications on 170 in total

DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials

Guillaume Grenet, Samia Mekhaldi, Sabine Mainbourg, Marine Auffret, Catherine Cornu, Jean-Luc Cracowski...

Diabetes Care . 44 ( 3 ) : e36-e37

DOI: 10.2337/dc20-2018

Journal article

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Needs for re-intervention on restored teeth in adults: a practice-based study

Franck Decup, Emmanuelle Dantony, Charlène Chevalier, Alexandra David, Valentin Garyga, Marie Tohmé...

Clinical Oral Investigations . 26 ( 1 ) : 789-801

DOI: 10.1007/s00784-021-04058-5

Journal article

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Olaparib in recurrent IDH-mutant high-grade glioma (OLAGLI).

François Ducray, Marc Sanson, O. Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15_suppl ) : 2007-2007

DOI: 10.1200/JCO.2021.39.15_suppl.2007

Conference paper

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Effect of periodontal treatment on the glomerular filtration rate, reduction of inflammatory markers and mortality in patients with chronic kidney disease: A systematic review

T. Delbove, F. Gueyffier, L. Juillard, E. Kalbacher, D. Maucort-Boulch, P. Nony...

PLoS ONE . 16 ( 1 ) : e0245619

DOI: 10.1371/journal.pone.0245619

Journal article

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Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal, Karen Brengel-Pesce, Alexandre Gaymard, Grégory Quéromès, Nicolas Guibert, Emilie Frobert...

Scientific Reports . 11 ( 1 ) : 14977

DOI: 10.1038/s41598-021-93828-y

Journal article

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Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials

Sophie Sun, Lucie Hisland, Guillaume Grenet, François Gueyffier, Catherine Cornu, Nemat Jaafari...

Thérapie .

DOI: 10.1016/j.therap.2021.10.002

Journal article

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Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Expected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures

Simon Pageaud, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe...

Vaccines . 9 ( 12 ) : 1462

DOI: 10.3390/vaccines9121462

Journal article

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Adapting French COVID-19 vaccination campaign duration to variant dissemination

Simon Pageaud, Nicolas Ponthus, Romain Gauchon, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel...

: p. 24

Report

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Impact of terminating reimbursement of symptomatic slow-acting drugs in osteoarthritis in France on volume and cost of drug deliveries, assessed with administrative databases

K. Mari, F. Rannou, F. Guillemin, M. Elegbede, F. Gueyffier, G. Badot...

Seminars in Arthritis and Rheumatism . 50 : 1307 - 1313

DOI: 10.1016/j.semarthrit.2020.09.001

Journal article

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Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock

J. Tallon, B. Browning, F. Couenne, C. Bordes, F. Venet, P. Nony...

In Silico Biology . 13 ( 3-4 ) : 101-121

DOI: 10.3233/ISB-200474

Journal article

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Drug prescription goals in primary care: a cross-sectional study

Louis Bernard, René Écochard, François Gueyffier, Laurent Letrilliart

BMC Health Services Research . 20 ( 1 ) : 6

DOI: 10.1186/s12913-019-4870-y

Journal article

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Prevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis

Sabine Mainbourg, Alexandra Addario, Maxime Samson, Xavier Puéchal, Mathilde François, Stéphane Durupt...

Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849

DOI: 10.1002/acr.23901

Journal article

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Assessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study

S. Trouillet-Assant, C. Albert Vega, A. Bal, J. A. Nazare, P. Fascia, A. Paul...

BMJ Open . 10 ( 11 ) : e041268

DOI: 10.1136/bmjopen-2020-041268

Journal article

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Inconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis

Sébastien Mateo, Julie Di Marco, Michel Cucherat, François Gueyffier, Gilles Rode

Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240

DOI: 10.1016/j.rehab.2019.05.008

Journal article

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Syndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?

Jordan Teoli, Claire Bardel, Marie Fablet, Gabriel Marais, François Gueyffier, Jean-François Lemaître...

36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194

DOI: 10.1016/j.ando.2020.07.150

Conference paper

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Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials

Aurélien Hugues, Julie Di Marco, Isabelle Bonan, Gilles Rode, Michel Cucherat, François Gueyffier

PLoS ONE . 15 ( 3 ) : e0229822

DOI: 10.1371/journal.pone.0229822

Journal article

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Association between difference in blood pressure reduction and risk of cardiovascular events in a type 2 diabetes population: A meta-regression analysis

G. Grenet, H. H. Le, T. Bejan-Angoulvant, S. Erpeldinger, R. Boussageon, B. Kassai...

Diabetes Metab .

DOI: 10.1016/j.diabet.2019.05.003

Journal article

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GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis

G. Grenet, S. Ribault, G. B. Nguyen, F. Glais, A. Metge, T. Linet...

PLoS ONE . 14 ( 6 ) : e0217701

DOI: 10.1371/journal.pone.0217701

Journal article

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INN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice

Florent De Bruyne, Arnaud Ponçon, Joris Giai, Xavier Dode, Cyrille Colin, François Gueyffier...

European Journal of Clinical Pharmacology . 75 ( 2 ) : 275-283

DOI: 10.1007/s00228-018-2580-8

Journal article

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GoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial

Valentin Garyga, Florian Pochelu, Béatrice Thivichon-Prince, Walid Aouini, Julie Santamaria, France Lambert...

Trials . 20 ( 1 ) : 699

DOI: 10.1186/s13063-019-3738-0

Journal article

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Minoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial

Behrouz Kassai, Philippe Bouyé, Brigitte Gilbert-Dussardier, François Godart, Jean-Benoit Thambo, Massimiliano Rossi...

BMC Pediatrics . 19 ( 1 ) : 170

DOI: 10.1186/s12887-019-1544-1

Journal article

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Comparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect

Guillaume Grenet, Corentin Blanc, Claire Bardel, François Gueyffier, Pascal Roy

Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64

DOI: 10.1111/bcpt.13293

Journal article

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Comparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect

Guillaume Grenet, Corentin Blanc, Claire Bardel, François Gueyffier, Pascal Roy

Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64

DOI: 10.1111/bcpt.13293

Journal article

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The contribution of genomics in the medicine of tomorrow, clinical applications and issues

Bruno Laviolle, Patrice Denèfle, François Gueyffier, Élodie Bégué, Pascal Bilbault, Helene Esperou...

Thérapie . 74 ( 1 ) : 9-15

DOI: 10.1016/j.therap.2018.11.012

Journal article

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Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2019.02.003

Journal article

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Apport de la génomique dans la médecine de demain, applications cliniques et enjeux

Bruno Laviolle, Olivier Perche, François Gueyffier, Élodie Bégué, Pascal Bilbault, Hélène Esperou...

Thérapie . 74 ( 1 ) : 1-8

DOI: 10.1016/j.therap.2018.11.011

Journal article

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Immune system modelling in case of a septic shock

Jean Tallon, Françoise Couenne, Claire Bordes, Melaz Tayakout-Fayolle, Fabienne Venet, Guillaume Monneret...

29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098

DOI: 10.1016/B978-0-12-818634-3.50183-1

Book chapter

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The limitations of observation studies for decision making regarding drugs efficacy and safety

François Gueyffier, Michel Cucherat

Alternative and Complementary Therapies . 74 ( 2 ) : 181-185

DOI: 10.1016/j.therap.2018.11.001

Journal article

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