
Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 91 to 120 publications on 120 in total
Monogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 ) : 102361
Journal article
see the publicationSafety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database
Joint Bone Spine . 86 ( 3 ) : 343-350
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationRisk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.
Rheumatology . 57 : 1432–1438
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationAdding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors
Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186
DOI: 10.1002/art.40205
Journal article
see the publicationIntravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome
The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27
Journal article
see the publicationIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases
PLoS ONE . 12 ( 9 )
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationIdiopathic inflammatory myopathies and the lung
European Respiratory Review . 24 ( 136 ) : 216-238
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 : 883-91
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 ( 9 ) : 883-891
Journal article
see the publicationRisk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis
Autoimmunity Reviews . 13 : 595-608
Journal article
see the publicationConsistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation
PLoS ONE . 9 ( 3 ) : e91398
Journal article
see the publicationMutations in CECR1 associated with a neutrophil signature in peripheral blood
Pediatric Rheumatology . 12 : 44
Journal article
see the publicationConsistency of safety profile of new oral anticoagulants in patients with renal failure
Journal of Thrombosis and Haemostasis . 12 ( 2 ) : 337-43
DOI: 10.1111/jth.12486
Journal article
see the publicationCharacteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study
Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688
Journal article
see the publicationImpact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis
Journal of Thrombosis and Haemostasis . 98 : 97--102
DOI: 10.1111/jth.12294
Journal article
see the publicationPrognostic value of troponins in sepsis: a meta-analysis
Intensive Care Medicine . 39 : 1181-9
Journal article
see the publicationIsolated Recurrent Pleuritis Revealing Familial Mediterranean Fever in Adulthood
Respiration . 80 ( 3 ) : 262
DOI: 10.1159/000315474
Journal article
see the publicationPrésentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique
La Revue de Médecine Interne . 29 ( 8 ) : 669-672
Journal article
see the publicationWhen to stop in the quest of formes frustes of connective tissue disease ?
Clinical Rheumatology . 26 ( 4 ) : 615-616
Journal article
see the publication