Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Lega Jean-Christophe

Professeur d'université - praticien hospitalier

UCBL

Address: Centre Hospitalier Lyon Sud
69003 LYON

My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).

This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.

I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.

Publications

Display of 91 to 120 publications on 120 in total

Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 ) : 102361

DOI: 10.1016/j.autrev.2019.102361

2019

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/S0140-6736(19)31675-7

2019

Journal article

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A quest for Q fever

Laura Olivier-Gougenheim, Caroline Freychet, Sophie Collardeau-Frachon, Chantal Roure-Sobas, Sylvie Di Filippo, Roberto Riva...

The Lancet . 394 ( 10196 ) : 419

DOI: 10.1016/s0140-6736(19)31675-7

2019

Journal article

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Extended Anticoagulation for VTE

Vicky Mai, Charles-Antoine Guay, Laurie Perreault, Sébastien Bonnet, Laurent Bertoletti, Yves Lacasse...

Chest . 155 ( 6 ) : 1199-1216

DOI: 10.1016/j.chest.2019.02.402

2019

Journal article

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Safety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database

Natalia Cabrera, Jean-Christophe Lega, Behrouz Kassai, Carine Wouters, Anuela Kondi, Elvira Cannizzaro...

Joint Bone Spine . 86 ( 3 ) : 343-350

DOI: 10.1016/j.jbspin.2018.08.003

2019

Journal article

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Survival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature

M. R. Pokeerbux, J. Giovannelli, L. Dauchet, L. Mouthon, C. Agard, Jean-Christophe Lega...

Arthritis Research and Therapy . 21 ( 1 ) : 86

DOI: 10.1186/s13075-019-1867-1

2019

Journal article

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Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 )

DOI: 10.1016/j.autrev.2019.102361

2019

Journal article

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Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis

Thomas Barba, Romain Fort, Vincent Cottin, Steeve Provencher, Isabelle Durieu, Sabine Jardel...

Autoimmunity Reviews . 18 ( 2 ) : 113 - 122

DOI: 10.1016/j.autrev.2018.07.013

2019

Journal article

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Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis

Vicky Mai, Laurent Bertoletti, Michel Cucherat, Sabine Jardel, Claire Grange, Steeve Provencher...

PLoS ONE . 14 ( 4 ) : e0214134

DOI: 10.1371/journal.pone.0214134

2019

Journal article

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Risk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.

Zelie Guitton, Louis Terriou, Jean-Christophe Lega, Raphaele Nove-Josserand, Miguel Hie, Zahir Amoura...

Rheumatology . 57 : 1432–1438

DOI: 10.1093/rheumatology/key119

2018

Journal article

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Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry

Sabine Jardel, Xavier Puéchal, Alain Le Quellec, Christian Pagnoux, Mohamed Hamidou, François Maurier...

Autoimmunity Reviews . 17 ( 7 ) : 653--659

DOI: 10.1016/j.autrev.2018.01.022

2018

Journal article

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Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

2018

Journal article

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Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors

Xavier Puechal, Christian Pagnoux, Gabriel Baron, Thomas Quemeneur, Antoine Néel, Christian Agard...

Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186

DOI: 10.1002/art.40205

2017

Journal article

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Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome

Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Jean-Christophe Lega, Marc Lambert, Sophie Rivière...

The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27

DOI: 10.1016/j.amjmed.2017.05.023

2017

Journal article

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Isolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases

Sabine Jardel, Nicole Fabien, Arnaud Hot, Sandra Vukusic, Jacques Tebib, Vincent Cottin...

PLoS ONE . 12 ( 9 )

DOI: 10.1371/journal.pone.0185104

2017

Journal article

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Heterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study

Cécile Picard, Thierry Vincent, Jean-Christophe Lega, Sophie Hue, Françoise Fortenfant, Daniel Lakomy...

Immunologic Research . 64 ( 3 ) : 677-686

DOI: 10.1007/s12026-015-8774-6

2016

Journal article

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Tocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children

Natalia Cabrera, Agnes Duquesne, Marine Desjonquères, Jean-Paul Larbre, Jean-Christophe Lega, Nicole Fabien...

RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271

DOI: 10.1136/rmdopen-2016-000271

2016

Journal article

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Idiopathic inflammatory myopathies and the lung

Jean-Christophe Lega, Quitterie Reynaud, Alexandre Belot, Nicole Fabien, Isabelle Durieu, Vincent Cottin

European Respiratory Review . 24 ( 136 ) : 216-238

DOI: 10.1183/16000617.00002015

2015

Journal article

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Characteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study

Jean-Christophe Lega, Raphaèle Seror, Thomas Fassier, Olivier Aumaître, Isabelle Quere, Jacques Pourrat...

Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688

DOI: 10.1016/j.semarthrit.2013.09.001

2014

Journal article

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The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome

Jean-Christophe Lega, N. Fabien, Q. Reynaud, I. Durieu, S. Durupt, M. Dutertre...

Autoimmunity Reviews . 13 : 883-91

2014

Journal article

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The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome

Jean-Christophe Lega, Nicole Fabien, Quitterie Reynaud, Isabelle Durieu, Stéphane Durupt, Marine Dutertre...

Autoimmunity Reviews . 13 ( 9 ) : 883-891

DOI: 10.1016/j.autrev.2014.03.004

2014

Journal article

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Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis

Q. Reynaud, Jean-Christophe Lega, P. Mismetti, C. Chapelle, D. Wahl, P. Cathebras...

Autoimmunity Reviews . 13 : 595-608

2014

Journal article

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Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation

Jean-Christophe Lega, L. Bertoletti, C. Gremillet, C. Chapelle, P. Mismetti, M. Cucherat...

PLoS ONE . 9 ( 3 ) : e91398

DOI: 10.1371/journal.pone.0091398

2014

Journal article

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Mutations in CECR1 associated with a neutrophil signature in peripheral blood

Alexandre Belot, Evangeline Wassmer, Marinka Twilt, Jean-Christophe Lega, Leo Ah Zeef, Anthony Oojageer...

Pediatric Rheumatology . 12 : 44

DOI: 10.1186/1546-0096-12-44

2014

Journal article

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Consistency of safety profile of new oral anticoagulants in patients with renal failure

Jean-Christophe Lega, L. Bertoletti, C. Gremillet, C. Boissier, P. Mismetti, S. Laporte

Journal of Thrombosis and Haemostasis . 12 ( 2 ) : 337-43

DOI: 10.1111/jth.12486

2014

Journal article

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Impact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis

Jc. Lega, P. Mismetti, M. Cucherat, T. Fassier, L. Bertoletti, C. Chapelle...

Journal of Thrombosis and Haemostasis . 98 : 97--102

DOI: 10.1111/jth.12294

2013

Journal article

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Prognostic value of troponins in sepsis: a meta-analysis

F. Bessiere, S. Khenifer, J. Dubourg, I. Durieu, Jean-Christophe Lega

Intensive Care Medicine . 39 : 1181-9

DOI: 10.1007/s00134-013-2902-3

2013

Journal article

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Isolated Recurrent Pleuritis Revealing Familial Mediterranean Fever in Adulthood

J.C. Lega, C. Khouatra, Vincent Cottin, Jean-François Cordier

Respiration . 80 ( 3 ) : 262

DOI: 10.1159/000315474

2010

Journal article

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Présentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique

Jean-Christophe Lega, Vincent Cottin, Aurélien Schuller, Romain Lazor, Denis Jullien, Jean-François Cordier

La Revue de Médecine Interne . 29 ( 8 ) : 669-672

DOI: 10.1016/j.revmed.2007.12.017

2008

Journal article

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When to stop in the quest of formes frustes of connective tissue disease ?

Vincent Cottin, Jean-Christophe Lega, Nicole Fabien, Jean-François Cordier

Clinical Rheumatology . 26 ( 4 ) : 615-616

2007

Journal article

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