Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 91 to 120 publications on 120 in total
Predictive factors of renal involvement in cryoglobulinaemia: a retrospective study of 153 patients
Clinical Kidney Journal . 12 ( 3 ) : 365-372
DOI: 10.1093/ckj/sfy096
Journal article
see the publicationSafety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database
Joint Bone Spine . 86 ( 3 ) : 343-350
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationRisk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.
Rheumatology . 57 : 1432–1438
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationAdding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors
Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186
DOI: 10.1002/art.40205
Journal article
see the publicationIntravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome
The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27
Journal article
see the publicationIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases
PLoS ONE . 12 ( 9 )
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationIdiopathic inflammatory myopathies and the lung
European Respiratory Review . 24 ( 136 ) : 216-238
Journal article
see the publicationConsistency of safety profile of new oral anticoagulants in patients with renal failure
Journal of Thrombosis and Haemostasis . 12 ( 2 ) : 337-43
DOI: 10.1111/jth.12486
Journal article
see the publicationCharacteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study
Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 : 883-91
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 ( 9 ) : 883-891
Journal article
see the publicationRisk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis
Autoimmunity Reviews . 13 : 595-608
Journal article
see the publicationConsistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation
PLoS ONE . 9 ( 3 ) : e91398
Journal article
see the publicationMutations in CECR1 associated with a neutrophil signature in peripheral blood
Pediatric Rheumatology . 12 : 44
Journal article
see the publicationImpact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis
Journal of Thrombosis and Haemostasis . 98 : 97--102
DOI: 10.1111/jth.12294
Journal article
see the publicationPrognostic value of troponins in sepsis: a meta-analysis
Intensive Care Medicine . 39 : 1181-9
Journal article
see the publicationIsolated Recurrent Pleuritis Revealing Familial Mediterranean Fever in Adulthood
Respiration . 80 ( 3 ) : 262
DOI: 10.1159/000315474
Journal article
see the publicationPrésentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique
La Revue de Médecine Interne . 29 ( 8 ) : 669-672
Journal article
see the publicationWhen to stop in the quest of formes frustes of connective tissue disease ?
Clinical Rheumatology . 26 ( 4 ) : 615-616
Journal article
see the publication