Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Lega Jean-Christophe

Professeur d'université - praticien hospitalier

UCBL

Address: Centre Hospitalier Lyon Sud
69003 LYON

Tel: 33 04 78 86 33 01

Email

My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).

This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.

I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.

Publications

Display of 61 to 90 publications on 120 in total

Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis

Vicky Mai, Boun Kim Tan, Sabine Mainbourg, François Potus, Michel Cucherat, Jean-Christophe Lega...

Vascular Pharmacology . 139 : 106882

DOI: 10.1016/j.vph.2021.106882

Journal article

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Direct oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis

V. Mai, E. Marceau-Ferron, L. Bertoletti, Y. Lacasse, S. Bonnet, J.C. Lega...

Pharmacological Research . 163 : 105317

DOI: 10.1016/j.phrs.2020.105317

Journal article

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Assessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department

Julien Durand, Stéphanie Parat, Jean-Christophe Lega, Yessim Dargaud, Véronique Potinet, Laurent Jacquin...

Annales de Biologie Clinique . 79 ( 4 ) : 315-324

DOI: 10.1684/abc.2021.1658

Journal article

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Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Prevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine

Hervé Lobbes, Sabine Mainbourg, Jean-Christophe Lega

Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154

DOI: 10.1093/ndt/gfaa337

Journal article

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Bladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices

Pascal Rousset, Elodie Bischoff, Mathilde Charlot, Flavia Grangeon, Gil Dubernard, Philippe Paparel...

Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263

DOI: 10.1016/j.diii.2020.11.011

Journal article

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DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials

Guillaume Grenet, Samia Mekhaldi, Sabine Mainbourg, Marine Auffret, Catherine Cornu, Jean-Luc Cracowski...

Diabetes Care . 44 ( 3 ) : e36-e37

DOI: 10.2337/dc20-2018

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment

Arthur Mageau, Louis Terriou, Mikael Ebbo, Odile Souchaud-Debouverie, Corentin Orvain, Julie Graveleau...

American Journal of Hematology . 97 ( 1 ) : 10-17

DOI: 10.1002/ajh.26378

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Assessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department

Julien Durand, Stéphanie Parat, Jean-Christophe Lega, Yessim Dargaud, Véronique Potinet, Laurent Jacquin...

Annales de Biologie Clinique . 79 ( 4 ) : 315-324

DOI: 10.1684/abc.2021.1658

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology .

DOI: 10.1093/rheumatology/keab925

Journal article

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French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)

Benjamin Terrier, Raphaël Darbon, Cécile-Audrey Durel, Eric Hachulla, Alexandre Karras, Hélène Maillard...

Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351

DOI: 10.1186/s13023-020-01621-3

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega...

Arthritis Research & Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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ANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance

Benjamin Terrier, Pierre Charles, Olivier Aumaître, Alexandre Bélot, Bernard Bonnotte, Yoann Crabol...

La Presse Médicale . 49 ( 3 ) : 104031

DOI: 10.1016/j.lpm.2020.104031

Journal article

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The benefit–risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials

Natalia Cabrera, Gabriela Avila-Pedretti, Alexandre Belot, Jean-Paul Larbre, Sabine Mainbourg, Agnès Duquesne...

Rheumatology . 59 ( 9 ) : 2226-2236

DOI: 10.1093/rheumatology/keaa170

Journal article

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Rectal endometriosis: predictive MRI signs for segmental bowel resection

Pascal Rousset, Guillaume Buisson, Jean-Christophe Lega, Mathilde Charlot, Colin Gallice, Eddy Cotte...

European Radiology . 31 ( 2 ) : 884-894

DOI: 10.1007/s00330-020-07170-4

Journal article

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Prevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis

Sabine Mainbourg, Alexandra Addario, Maxime Samson, Xavier Puéchal, Mathilde François, Stéphane Durupt...

Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849

DOI: 10.1002/acr.23901

Journal article

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Severe infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis

Clémence Thery-Casari, Romain Euvrard, Sabine Mainbourg, Stéphane Durupt, Quitterie Reynaud, Isabelle Durieu...

Autoimmunity Reviews . 19 ( 5 ) : 102505

DOI: 10.1016/j.autrev.2020.102505

Journal article

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Dosage de la tryptase : un guide d'utilisation pour le clinicien

H. Lobbes, Q. Reynaud, S. Mainbourg, J.C. Lega, I. Durieu, S. Durupt

La Revue de Médecine Interne . 41 : 748 - 755

DOI: 10.1016/j.revmed.2020.06.006

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega...

Arthritis Research & Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

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L'acéruléoplasminémie héréditaire, une pathologie à ne pas méconnaître

H. Lobbes, Q. Reynaud, S. Mainbourg, J-C. Lega, I. Durieu, S. Durupt

La Revue de Médecine Interne . 41 : 769 - 775

DOI: 10.1016/j.revmed.2020.06.002

Journal article

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Recurrent superficial vein thrombosis revealing relapsing polychondritis associated with myelodysplastic syndrome

Axel Tabary, Jean-Christophe Lega, Sabine Mainbourg, Hervé Lobbes

Rheumatology . 59 ( 11 ) : 3581-3581

DOI: 10.1093/rheumatology/keaa185

Journal article

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Analysis of ncidence of hrombotic omplications in the resence of ompeting isks

Sabine Mainbourg, Michel Cucherat, Jean-Christophe Lega

Thrombosis Research . 191 : 152

DOI: 10.1016/j.thromres.2020.04.045

Journal article

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Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Emmanuel Ledoult, David Launay, Hélène Behal, Luc Mouthon, Gregory Pugnet, Jean-Christophe Lega...

Arthritis Research and Therapy . 22 ( 1 ) : 30

DOI: 10.1186/s13075-020-2113-6

Journal article

see the publication

French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)

Benjamin Terrier, Raphaël Darbon, Cécile-Audrey Durel, Eric Hachulla, Alexandre Karras, Hélène Maillard...

Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351

DOI: 10.1186/s13023-020-01621-3

Journal article

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Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Jérôme Hadjadj, Carla Noemi Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi...

Nature Communications . 11 ( 1 ) : 5341

DOI: 10.1038/s41467-020-18925-4

Journal article

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Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Alexandre Belot, Gillian Rice, Sulliman Ommar Omarjee, Quentin Rouchon, Eve Smith, Marion Moreews...

The Lancet Rheumatology . 2 ( 2 ) : e99-e109

DOI: 10.1016/S2665-9913(19)30142-0

Journal article

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Monogenic lupus: Dissecting heterogeneity

Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux-Laucat, Pauline Soulas-Sprauel...

Autoimmunity Reviews . 18 ( 10 ) : 102361

DOI: 10.1016/j.autrev.2019.102361

Journal article

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