Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Lega Jean-Christophe

Professeur d'université - praticien hospitalier

UCBL

Address: Centre Hospitalier Lyon Sud
69003 LYON

Tel: 33 04 78 86 33 01

Email

My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).

This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.

I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.

Publications

Display of 31 to 60 publications on 120 in total

The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

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Indirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis

Sabine Mainbourg, Axel Tabary, Michel Cucherat, François Gueyffier, Hervé Lobbes, Marie Aussedat...

Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835

DOI: 10.1016/j.mayocp.2022.03.010

Journal article

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Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis

Marie Aussedat, Hervé Lobbes, Maxime Samson, Romain Euvrard, Jean-Christophe Lega, Sabine Mainbourg

Autoimmunity Reviews . 21 ( 1 ) : 102930

DOI: 10.1016/j.autrev.2021.102930

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

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Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Élodie Tremblay, Camille Gosselin, Vicky Mai, Annie Lajoie, Roubi Kilo, Jason Weatherald...

Circulation . 146 ( 8 ) : 597-612

DOI: 10.1161/CIRCULATIONAHA.121.058635

Journal article

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Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients

Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat...

Arthritis Research and Therapy . 24 ( 1 ) : 167

DOI: 10.1186/s13075-022-02857-z

Journal article

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Effective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders

Julien Rossignol, Amani Ouedrani, Cristina Bulai Livideanu, Stéphane Barete, Louis Terriou, David Launay...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 5 ) : 1356-1364.e2

DOI: 10.1016/j.jaip.2021.12.038

Journal article

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Nécessité d’améliorer nos connaissances sur les pneumopathies interstitielles diffuses associées aux connectivites

Vincent Cottin, Jean-Christophe Lega, Fabienne Coury, Mouhamad Nasser

Revue du Rhumatisme .

DOI: 10.1016/j.rhum.2022.03.006

Journal article

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Screening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?

Delphine Thiolliere, Brahim Harbaoui, Claire Falandry, Marc Bonnefoy, Jean-Christophe Lega, Pierre Lantelme...

Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801

DOI: 10.11909/j.issn.1671-5411.2022.11.005

Journal article

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Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis

C. Mettler, Ca. Durel, P. Guilpain, B. Bonnotte, F. Cohen-Aubart, M. Hamidou...

European Journal of Internal Medicine . 96 : 97-101

DOI: 10.1016/j.ejim.2021.10.028

Journal article

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

see the publication

The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

see the publication

SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

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Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

Maxime Auroux, Benjamin Laurent, Baptiste Coste, Emmanuel Massy, Alexandre Mercier, Isabelle Durieu...

Revue du Rhumatisme . 89 ( 5 ) : 435-446

DOI: 10.1016/j.rhum.2022.07.002

Journal article

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VEXAS syndrome-related AA amyloidosis: a case report

Romain Euvrard, Thomas Fournier, Dana Georgescu, Estelle Bourbon, Pierre Sujobert, Jean Christophe Lega...

Rheumatology . 61 ( 1 ) : e15-e16

DOI: 10.1093/rheumatology/keab683

Journal article

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Infection Risk in Patients with Dermatomyositis Associated with Anti-MDA5 Antibodies: A Historical Cohort Study

Anne-Claire Billet, Thomas Barba, Frédéric Coutant, Nicole Fabien, Laurent Perard, Pascal Sève...

Biomedicines . 10 ( 12 ) : 3176

DOI: 10.3390/biomedicines10123176

Journal article

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Human Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination

Emmanuelle David, Pascal Roy, Alexandre Belot, Pierre Quartier, Brigitte Bader-Meunier, Florence Aeschlimann...

Journal of Clinical Medicine . 11 ( 14 ) : 4137

DOI: 10.3390/jcm11144137

Journal article

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A call for evidence in connective tissue diseases-associated interstitial lung disease

Vincent Cottin, Jean-Christophe Lega, Fabienne Coury, Mouhamad Nasser

Joint Bone Spine . 89 ( 1 ) : 105274

DOI: 10.1016/j.jbspin.2021.105274

Journal article

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Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment

Arthur Mageau, Louis Terriou, Mikael Ebbo, Odile Souchaud‐debouverie, Corentin Orvain, Julie Graveleau...

American Journal of Hematology . 97 ( 1 ) : 10-17

DOI: 10.1002/ajh.26378

Journal article

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Management and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study

Marion Douplat, Antoine Gavoille, Fabien Subtil, Julie Haesebaert, Laurent Jacquin, Guillaume Durand...

Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906

DOI: 10.5811/westjem.2022.7.57135

Journal article

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Human Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination

Emmanuelle David, Pascal Roy, Alexandre Belot, Pierre Quartier, Brigitte Bader Meunier, Florence Aeschlimann...

Journal of Clinical Medicine . 11 ( 14 ) : 4137

DOI: 10.3390/jcm11144137

Journal article

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Paraneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma

Inès Chircop, Amélie Boespflug, Antoine Cini, Jean Christophe Lega, Stéphane Dalle

The Lancet Haematology . 8 ( 3 ) : e240

DOI: 10.1016/S2352-3026(20)30393-8

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Significant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis

Vicky Mai, Sabine Mainbourg, Boun Kim Tan, Jean-Christophe Lega, Steeve Provencher

Thrombosis and Haemostasis . 121 ( 12 ) : 1670-1673

DOI: 10.1055/a-1477-4027

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphaël Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

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Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases

Suzanne Béra, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Stéphane Durupt, Raphaèle Nove-Josserand, Jean-Christophe Lega...

Journal of Clinical Medicine . 11 ( 1 ) : 32

DOI: 10.3390/jcm11010032

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

see the publication