Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 31 to 60 publications on 120 in total
Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895
Journal article
see the publicationThe consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629
Journal article
see the publicationSGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits
Diabetologia . 65 : 2000-2010
Journal article
see the publicationRéponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse
Revue du Rhumatisme . 89 ( 5 ) : 435-446
Journal article
see the publicationVEXAS syndrome-related AA amyloidosis: a case report
Rheumatology . 61 ( 1 ) : e15-e16
Journal article
see the publicationIndirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis
Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835
Journal article
see the publicationEpidemiology of major relapse in giant cell arteritis: A study-level meta-analysis
Autoimmunity Reviews . 21 ( 1 ) : 102930
Journal article
see the publicationImmune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients
Rheumatology . 61 ( 9 ) : 3627-3639
Journal article
see the publicationIntravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895
Journal article
see the publicationAssessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Circulation . 146 ( 8 ) : 597-612
Journal article
see the publicationCryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients
Arthritis Research and Therapy . 24 ( 1 ) : 167
Journal article
see the publicationEffective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 5 ) : 1356-1364.e2
Journal article
see the publicationNécessité d’améliorer nos connaissances sur les pneumopathies interstitielles diffuses associées aux connectivites
Revue du Rhumatisme .
Journal article
see the publicationScreening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?
Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801
Journal article
see the publicationOff-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis
European Journal of Internal Medicine . 96 : 97-101
Journal article
see the publicationInfection Risk in Patients with Dermatomyositis Associated with Anti-MDA5 Antibodies: A Historical Cohort Study
Biomedicines . 10 ( 12 ) : 3176
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationCharacteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract
Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441
Journal article
see the publicationParaneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma
The Lancet Haematology . 8 ( 3 ) : e240
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationMeta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality
Scientific Reports . 11 ( 1 ) : 14728
Journal article
see the publicationMeta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality
Scientific Reports . 11 ( 1 ) : 14728
Journal article
see the publicationSignificant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis
Thrombosis and Haemostasis . 121 ( 12 ) : 1670-1673
DOI: 10.1055/a-1477-4027
Journal article
see the publicationCharacteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract
Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441
Journal article
see the publicationInflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases
Journal of Clinical Medicine . 11 ( 1 ) : 32
DOI: 10.3390/jcm11010032
Journal article
see the publication