Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Goutelle Sylvain

Professeur d'université - praticien hospitalier

UCBL

Address: 136 rue du Commandant Charcot
69322 Lyon cedex 05

Tel: 33 04 72 16 80 99

Email

Publications

Display of 31 to 60 publications on 113 in total

Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study

Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac...

Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454

DOI: 10.1097/FTD.0000000000000896

Journal article

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Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Romain Garreau, Romain Bricca, Marie-Claude Gagnieu, Sandrine Roux, Anne Conrad, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257

DOI: 10.1093/jac/dkab006

Journal article

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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Vianney Tuloup, Mathilde France, Romain Garreau, Nathalie Bleyzac, Laurent Bourguignon, Michel Tod...

Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321

DOI: 10.1128/AAC.01043-21

Journal article

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Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Romain Garreau, Benoît Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod...

Antibiotics . 10 ( 10 ) : 1228

DOI: 10.3390/antibiotics10101228

Journal article

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Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

Charlotte Genestet, Elisabeth Hodille, Alexia Barbry, Jean-Luc Berland, Jonathan Hoffmann, Emilie Westeel...

PLoS Pathogens . 17 ( 6 ) : e1009643

DOI: 10.1371/journal.ppat.1009643

Journal article

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Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children

Hanen Marsit, Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Michel Ducher...

Clinical Pharmacokinetics . 59 ( 8 ) : 1049-1061

DOI: 10.1007/s40262-020-00877-z

Journal article

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Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

Tristan Ferry, Thomas Lodise, Jason Gallagher, Emmanuel Forestier, Sylvain Goutelle, Vincent Tam...

Frontiers in Medicine . 7 : 585658

DOI: 10.3389/fmed.2020.585658

Journal article

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Nonparametric Methods in Population Pharmacokinetics

Sylvain Goutelle, Jean-Baptiste Woillard, Michael Neely, Walter Yamada, Laurent Bourguignon, Jean‐baptiste Woillard

Journal of Clinical Pharmacology . 62 ( 2 ) : 142-157

DOI: 10.1002/jcph.1650

Journal article

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Drug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction

Claire Le Corvaisier, Aude Capelle, Mathilde France, Laurent Bourguignon, Michel Tod, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 35 ( 2 ) : 208-216

DOI: 10.1111/fcp.12601

Journal article

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Azithromycin for COVID-19: More Than Just an Antimicrobial?

Nathalie Bleyzac, Sylvain Goutelle, Laurent Bourguignon, Michel Tod

Clinical Drug Investigation . 40 ( 8 ) : 683-686

DOI: 10.1007/s40261-020-00933-3

Journal article

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Quantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8

Michel Tod, Laurent Bourguignon, Nathalie Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 59 ( 6 ) : 757-770

DOI: 10.1007/s40262-019-00853-2

Journal article

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Erratum à l’article : « Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie (Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review) [Presse Med. 2019;48:563–581]

Anne-Margaux Belat, Audrey Haquin, Marc O'Brien, Sylvain Goutelle, Blandine de la Gastine, Marc O’brien

La Presse Médicale . 48 ( 11 ) : 1360

DOI: 10.1016/j.lpm.2019.11.003

Journal article

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Parameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study

Nicolas Benech, Oana Dumitrescu, Oana Dumitrescu, Anne Conrad, Anne Conrad, Marie Balsat...

Journal of Antimicrobial Chemotherapy . 74 ( 9 ) : 2676-2680

DOI: 10.1093/jac/dkz248

Journal article

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[Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review].

Anne-Margaux Belat, Audrey Haquin, Marc O'Brien, Sylvain Goutelle, Blandine de la Gastine, Marc O’brien

La Presse Médicale . 48 ( 5 ) : 563-567

DOI: 10.1016/j.lpm.2019.04.007

Journal article

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Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Clément Boidin, Laurent Bourguignon, Sabine Cohen, Claire Roger, Jean-Yves Lefrant, Jason A. Roberts...

Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19

DOI: 10.1128/AAC.00993-19

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Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review

Clément Boidin, Parastou Moshiri, Claire Dahyot-Fizelier, Sylvain Goutelle, Sandrine Lefeuvre

Anaesthesia Critical Care & Pain Medicine .

DOI: 10.1016/j.accpm.2019.07.016

Journal article

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Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children

Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Nathalie Bleyzac, Sylvain Goutelle

Bone Marrow Transplantation . 54 ( 3 ) : 448-457

DOI: 10.1038/s41409-018-0281-7

Journal article

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[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].

L. Lafarge, L. Bourguignon, N. Bernard, T. Vial, M.-J. Dehan-Moya, B. de la Gastine...

Annales de Cardiologie et d'Angéiologie . 67 ( 2 ) : 91-97

DOI: 10.1016/j.ancard.2018.02.001

Journal article

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Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

Nicolas Fermier, Laurent Bourguignon, Sylvain Goutelle, Nathalie Bleyzac, Michel Tod

Clinical Pharmacokinetics . 57 ( 12 ) : 1581-1591

DOI: 10.1007/s40262-018-0651-8

Journal article

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A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4

Michel Tod, Sylvain Goutelle, N. Bleyzac, L. Bourguignon

Clinical Pharmacokinetics . 58 ( 4 ) : 503-523

DOI: 10.1007/s40262-018-0711-0

Journal article

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Comment on: MIC-based dose adjustment: facts and fables

Sylvain Goutelle, Charlotte Genestet, Florence Ader, Gérard Lina, Oana Dumitrescu

Journal of Antimicrobial Chemotherapy . 73 ( 9 ) : 2584-2585

DOI: 10.1093/jac/dky131

Journal article

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Population Pharmacokinetic Study of Amoxicillin-Treated Burn Patients Hospitalized at a Swiss Tertiary-Care Center

Anne Fournier, Sylvain Goutelle, Yok-Ai Que, Philippe Eggimann, Olivier Pantet, Farshid Sadeghipour...

Antimicrobial Agents and Chemotherapy . 62 ( 9 )

DOI: 10.1128/AAC.00505-18

Journal article

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

Journal article

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

Journal article

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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 62 ( 1 )

DOI: 10.1128/AAC.01413-17

Journal article

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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?

M Tod, Sylvain Goutelle, L Bourguignon, N Bleyzac

CPT: Pharmacometrics and Systems Pharmacology . 6 ( 4 ) : 226-226

DOI: 10.1002/psp4.12164

Journal article

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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

Journal article

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

Journal article

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

Journal article

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