Functional Evolutionary Genomics Group

Members

In the "Functional evolutionary genomics" team, one of our ovearching aims is understanding the genomic basis of phenotypic evolution. We are particularly interested in convergent phenotypic evolution events. We study a wide range of phenotypic traits, including morphological traits, sensory traits, physiological traits. Our aim is to identify the genomic changes that accompany phenotypic evolution. We also aim to characterize the evolutionary processes that underlie phenotypic changes, by searching for instances of lineage-specific positive selection or relaxation of purifying selection.

We study both protein-coding gene evolution and non-coding DNA evolution, in particular regulatory elements that control gene expression. We aim to develop new methods for this purpose, and rely on statistical inference, including deep learning.

Publications

Display of 31 to 60 publications on 136 in total

Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness

Alexandre Laverré, Eric Tannier, Anamaria Necsulea

Genome Research . 32 ( 2 ) : 280-296

DOI: 10.1101/gr.275901.121

Journal article

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Comparison of developmental genome expression in rodent molars reveals extensive developmental system drift

Marie Sémon, Laurent Guéguen, Coraline Petit, Carine Rey, Anne Lambert, Manon Peltier...

DOI: 10.1101/2020.04.22.043422

Preprint

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Relative time constraints improve molecular dating

Gergely J Szöllősi, Sebastian Höhna, Tom A Williams, Dominik Schrempf, Vincent Daubin, Bastien Boussau

DOI: 10.1101/2020.10.17.343889

Preprint

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A Codon Model for Associating Phenotypic Traits with Altered Selective Patterns of Sequence Evolution

Keren Halabi, Eli Levy Karin, Laurent Guéguen, Itay Mayrose

Systematic Biology . 70 ( 3 ) : 608-622

DOI: 10.1093/sysbio/syaa087

Journal article

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Predicted effects of summer holidays and seasonality on the SARS-Cov-2 epidemic in France

Louis Duchemin, Mathilde Paris, Bastien Boussau

medRxiv : the preprint server for health sciences .

DOI: 10.1101/2020.07.06.20147660

Preprint

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Treerecs: an integrated phylogenetic tool, from sequences to reconciliations.

Nicolas Comte, Benoît Morel, Damir Hasic, Laurent Guéguen, Bastien Boussau, Vincent Daubin...

Bioinformatics . 36 ( 18 ) : 4822-4824

DOI: 10.1093/bioinformatics/btaa615

Journal article

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Reconciling Gene trees with Species Trees

Bastien Boussau, Celine Scornavacca

Phylogenetics in the Genomic Era . : 3.2:1--3.2:23

Book chapter

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Ancestral Genome Organization as a Diagnosis Tool for Phylogenomics

Eric Tannier, Adelme Bazin, Adrián Davín, Laurent Guéguen, Sèverine Bérard, Cedric Chauve

Phylogenetics in the Genomic Era . : 2.5:1--2.5:19

Book chapter

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DGINN, an automated and highly-flexible pipeline for the detection of genetic innovations on protein-coding genes

Lea Picard, Quentin Ganivet, Omran Allatif, Andrea Cimarelli, Laurent Guéguen, Lucie Etienne

Nucleic Acids Research . 48 ( 18 ) : e103-e103

DOI: 10.1093/nar/gkaa680

Journal article

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Phylogenomics and Genome Annotation

Anamaria Necsulea

Phylogenetics in the Genomic Era . : 4.1:1--4.1:26

Book chapter

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Phylogenomics, convergent evolution, and the Anthropocene

Bastien Boussau

HDR

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Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs

Fabrice Darbellay, Anamaria Necsulea

Molecular Biology and Evolution .

DOI: 10.1093/molbev/msz212

Journal article

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Tracing Human Ancestral Migrations Using Symbiotic Bacteria

Alexia Nguyen Trung, Bastien Boussau, Vincent Daubin

Groupe des Méthodes Pluridisciplinaires Contribuant à l'Archéologie (GMPCA) .

Conference paper

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GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes

Paulina Bolívar, Laurent Guéguen, Laurent Duret, Hans Ellegren, Carina Mugal

Genome Biology . 20 ( 1 )

DOI: 10.1186/s13059-018-1613-z

Journal article

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Detecting adaptive convergent amino acid evolution

Carine Rey, Vincent Lanore, Philippe Veber, Laurent Guéguen, Nicolas Lartillot, Marie Sémon...

Philosophical Transactions of the Royal Society B: Biological Sciences . 374 ( 1777 ) : 1-11

DOI: 10.1098/rstb.2018.0234

Journal article

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Gene transfers can date the tree of life

Adrián Davín, Eric Tannier, Tom A Williams, Bastien Boussau, Vincent Daubin, Gergely Szöllősi

Nature Ecology & Evolution . 2 ( 5 ) : 904-909

DOI: 10.1038/s41559-018-0525-3

Journal article

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Unbiased Estimate of Synonymous and Nonsynonymous Substitution Rates with Nonstationary Base Composition

Laurent Guéguen, Laurent Duret

Molecular Biology and Evolution . 35 ( 3 ) : 734-742

DOI: 10.1093/molbev/msx308

Journal article

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RecPhyloXML: a format for reconciled gene trees

Wandrille Duchemin, Guillaume Gence, Anne-Muriel Arigon Chifolleau, Lars Arvestad, Mukul Bansal, Vincent Berry...

Bioinformatics . 34 ( 21 ) : 3646-3652

DOI: 10.1093/bioinformatics/bty389

Journal article

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Life History Traits Impact the Nuclear Rate of Substitution but Not the Mitochondrial Rate in Isopods

Nathanaëlle Saclier, Clémentine François, Lara Konecny-Dupré, Nicolas Lartillot, Laurent Guéguen, L. Duret...

Molecular Biology and Evolution . 35 ( 12 ) : 2900-2912

DOI: 10.1093/molbev/msy184

Journal article

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Biodiversité, évolution et fonctionnement des écosystèmes

Isabelle Arzul, Salvador Bailon, David Bass, Pierre Boudry, Philippe Béarez, Elodie Blanchard...

Les Cahiers des prospectives . hors série : 25-33.

Book chapter

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MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

Aurélie Siberchicot, Adrien Bessy, Laurent Gueguen, Gabriel A. B. Marais

Genome Biology and Evolution . 9 ( 10 ) : 2506-2509

DOI: 10.1093/gbe/evx178

Journal article

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Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology

S. Pantalacci, Laurent Guéguen, C. Petit, A. Lambert, R. Peterkova, M. Sémon

Genome Biology . 18 : 29

DOI: 10.1186/s13059-017-1157-7

Journal article

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Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver

T. Boldanova, A. Suslov, M.H. Heim, A. Necsulea

EMBO Molecular Medicine . 9 : 816-834

DOI: 10.15252/emmm.201607006

Journal article

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Ancestral Genome Estimation Reveals the History of Ecological Diversification in Agrobacterium

Florent Lassalle, Rémi Planel, Simon Penel, David Chapulliot, Valérie Barbe, Audrey Dubost...

Genome Biology and Evolution . 9 ( 12 ) : 3413 - 3431

DOI: 10.1093/gbe/evx255

Journal article

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MaxTiC: Fast Ranking Of A Phylogenetic Tree By Maximum Time Consistency With Lateral Gene Transfers

Cédric Chauve, Akbar A Rafiey, Adrian A Davin, Celine Scornavacca, Philippe Veber, Bastien Boussau...

DOI: 10.1101/127548

Other publication

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Integrative modeling of gene and genome evolution roots the archaeal tree of life

Tom Williams, Gergely Szöllősi, Anja Spang, Peter Foster, Sarah Heaps, Bastien Boussau...

Proceedings of the National Academy of Sciences of the United States of America . 114 ( 23 ) : E4602-E4611

DOI: 10.1073/pnas.1618463114

Journal article

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The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

Baptiste Saudemont, Alexandra Popa, Joanna Parmley, Vincent Rocher, Corinne Blugeon, Anamaria Necsulea...

Genome Biology . 18 : 208

DOI: 10.1186/s13059-017-1344-6

Journal article

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