Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 181 to 210 publications on 225 in total

TESD : a transposable element dynamics simulation environment

G. Deceliere, Y. Letrillard, Sandrine Charles, C. Biémont

Bioinformatics . 22 : 2702-2703

Journal article

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First step of a modeling approach to evalue spatial heterogeneity in fish (Cottus gobio) population dynamics

Arnaud Chaumot, N. Milioni, A. Abdoli, D. Pont, Sandrine Charles

Ecological Modelling . 197 : 263-273

Journal article

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Un dispositif web pour l'enseignement des mathématiques à l'université : quels impacts sur la performance et la motivation des étudiants ?

Mônica Macedo-Rouet, Sandrine Charles, Muriel Ney, Christophe Batier, Lionel Humblot, Eddy Marquez...

STICEF (Sciences et Technologies de l'Information et de la Communication pour l'Éducation et la Formation) . 13 : 17 pages

Journal article

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First step of a modeling approach to evaluate spatial heterogeneity in a fish (Cottus gobio) population dynamics

Arnaud Chaumot, Nikoletta Milioni, Asghar Abdoli, Didier Pont, Sandrine Charles

Ecological Modelling . 197 ( 3-4 ) : 263-273

DOI: 10.1016/j.ecolmodel.2006.03.024

Journal article

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Population dynamics of grayling: Modelling temperature and discharge effects

Sandrine Charles, J.-P. Mallet, H. Persat

Mathematical Modelling of Natural Phenomena . 1 : 33-48

Journal article

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Ecotoxicology and population dynamics: Using DEBtox models in a Leslie modeling approach

C. Lopes, A.R.R. Péry, Arnaud Chaumot, S. Charles

Ecological Modelling . 188 ( 1 ) : 30-40

DOI: 10.1016/j.ecolmodel.2005.05.004

Journal article

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Ecotoxicology and population dynamics: on the use of DEBtox models in a Leslie modelling approach

C. Lopes, A. Pery, Arnaud Chaumot, S. Charles

Ecological Modelling . 188 : 30-40

Journal article

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The Dynamics of Transposable Elements in Structured Populations

G. Décelière, Sandrine Charles, C. Biémont

Genetics . 169 : 467-474

Journal article

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Are well-designed Web sites efficient for learning mathematics at the undergraduate level?

Muriel Ney, Mônica Macedo-Rouet, Sandrine Charles, Geneviève Lallich-Boidin

11th EARLI biennal conference . : 472

Conference paper

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Ecotoxicologie aquatique et modélisation des effets biologiques. Rapport final

A. Pery, Laurent Lagadic, S. Charles, M. Servia, Jeanne Garric

: 55

Report

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Food availability effect on population dynamics of the midge Chironomus riparius: a Leslie modeling approach

S. Charles, M. Ferreol, Arnaud Chaumot, A.R. Pery

Ecological Modelling . 175 ( 3 ) : 217-229

DOI: 10.1016/j.ecolmodel.2003.10.016

Journal article

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Les modèles matriciels de type Leslie : Une approche couplée Mathématiques et Statistiques

S. Charles-Bajard

incollection . -- : 377-392

Journal article

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Mathématiques et Informatique du Vivant " : une formation interdisciplinaire qui voit le jour grâce au LMD

Sandrine Charles

21ème congrès de l'AIPU (Association internationale de pédagogie universitaire) . : 1820-1822

Conference paper

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Un site web pour l`enseignement interdisciplinaire des Mathématiques en Biologie

Sandrine Charles, Michel Ney, Dominique Mouchiroud, L. Humblot, C. Batier

EIAH (Environnement Informatique d`Apprentissage Humain) . -- : 445-452

Journal article

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Quelques problèmes statistiques rencontrés dans l`estimation de la température minimale de croissance de Listeria monocytogenes

S. Charles-Bajard, Jean-Pierre Flandrois, R. Tomassone

Revue de Statistique Appliquée . LI : 59-71

Journal article

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Les étudiants en première année à l`Université des Sciences : innover pour motiver

Michel Ney, Sandrine Charles

20ème Congrès AIPU (Association Internationale de Pédagogie Universitaire) . : 157-165

Conference paper

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Ecotoxicology and spatial modeling in population dynamics: an illustration with brown trout

Arnaud Chaumot, Sandrine Charles, P. Flammarion, P. Auger

Environmental Toxicology and Chemistry . 22 : 958-969

Journal article

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Do migratory or demographic disruptions rule the population impact of pollution in spatial networks?

Arnaud Chaumot, Sandrine Charles, P. Flammarion, P. Auger

Theoretical Population Biology . 64 : 473-480

Journal article

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Un site web pour l'enseignement interdisciplinaire des mathématiques en biologie

Sandrine Charles, Muriel Ney, Dominique Mouchiroud, Lionel Humblot, Christophe Batier

EIAH 2003 (Environnements Informatiques pour l'Apprentissage Humain) . : 8 pages

Conference paper

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Un site web pour l'enseignement inter-disciplinaire des Mathématiques en Biologie

Sandrine Charles, Muriel Ney, Dominique Mouchiroud, Lionel Humblot, Christophe Batier

Environnements Informatiques pour l'Apprentissage Humain 2003 . http://atief.org ; http://www.inrp.fr : 445-452

Conference paper

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Using aggregation methods to assess toxicant effects on population dynamics in spatial systems

Arnaud Chaumot, Sandrine Charles, P. Flammarion, J. Garric, P. Auger

Ecological Applications . 12 : 1771-1784

Journal article

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Host Patch Selection Induced by Parasitism: Basic Reproduction Ratio R0 and Optimal Virulence

Sandrine Charles, S. Morand, J.-L. Chassé, P. Auger

Theoretical Population Biology . 62 : 97-109

Journal article

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A mathematical model describing the thermal virus inactivation

C. Noel, Sandrine Charles, A. Francon, Jean-Pierre Flandrois

Vaccine . 19 : 3575-3582

Journal article

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Using variables aggregation methods to assess toxicant effects on fish populations in river networks

Arnaud Chaumot, S. Charles, Patrick Flammarion, Jeanne Garric, P. Auger

10th annual meeting of SETAC Europe, Brighton, GBR, 21-25 mai 1999 .

Conference paper

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Discussion et commentaires - La planification des expériences : choix des traitements et dispositif expérimental

R. Tomassone, S. Charles-Bajard, L. Bellanger

Journal de la Société Française de Statistique . 141 : 59-64

Journal article

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Annual spawning migrations in modelling brown trout population dynamics inside an arborescent river network

Sandrine Charles, R. Bravo de La Parra, J.-P. Mallet, H. Persat, P. Auger

Ecological Modelling . 133 : 15-31

Journal article

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Emergence of individual behaviour at the population level. Effects of density-dependent migration on population dynamics

P. Auger, J.-C. Poggiale, Sandrine Charles

Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie . 323 : 119-127

Journal article

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Aggregation and emergence in ecological modelling: integration of ecological levels

P. Auger, Sandrine Charles, M. Viala, J.-C. Poggiale

Ecological Modelling . 127 : 11-20

Journal article

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Artificial intelligence and meaning--some philosophical aspects of decision-making

P. Acot, Sandrine Charles, Marie Laure Delignette-Muller

Acta Biotheoretica . 48 : 173-179

Journal article

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Development of an ecotoxicological model in an arborescent river network: an attempt with a brown trout population

Arnaud Chaumot, S. Charles, P. Auger, Patrick Flammarion, Jeanne Garric

Challenges in applied population biology AAB meeting Aspects of Applied Biology 53, University London, GBR, 8-9 juillet 1999 . : 131-136

Conference paper

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