Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 151 to 180 publications on 225 in total

Matrix population models as relevant modeling tools in ecotoxicology

S. Charles, Elise Billoir, C. Lopes, Arnaud Chaumot, James Devillers

Ecotoxicology Modeling, Emerging Topics in Ecotoxicology: Principles, Approaches and Perspectives 2 . : 261-298

Book chapter

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Toxicity of ivermectin on cladocerans: comparison of toxic effects on Daphnia and Ceriodaphnia species

C. Lopes, S. Charles, B. Vollat, Jeanne Garric

Environmental Toxicology and Chemistry . 28 ( 10 ) : 2160-2166

Journal article

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DEBtox theory and matrix population models as helpful tools in understanding the interaction between toxic cyanobacteria and zooplankton

E. Billoir, A. da Silva Ferrão-Filho, Marie Laure Delignette-Muller, Sandrine Charles

Journal of Theoretical Biology . 258 : 380-388

Journal article

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Comparison of spatially implicit and explicit approaches to model plant infestation by insect pests

Christelle Lopes, Thierry Spataro, Roger Arditi

Ecological Complexity . 7 ( 1 ) : 1 - 12

DOI: 10.1016/j.ecocom.2009.03.006

Journal article

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À propos de la biométrie

Sandrine Charles, Joanna Jongwane

Interstices .

Journal article

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Des espèces en nombre

Sandrine Charles, Hubert Charles

Interstices .

Journal article

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Student's Performance and Satisfaction with Web vs. paper-based practice quizzes and lecture notes

Mônica Macedo-Rouet, Muriel Ney, Sandrine Charles, Geneviève Lallich-Boidin

Computers and Education . 53 ( 2 ) : 375-384

DOI: 10.1016/j.compedu.2009.02.013

Journal article

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DEBtox theory and matrix population models as helpful tools in understanding the interaction between toxic cyanobacteria and zooplankton

Elise Billoir, Aloysio da Silva Ferrão-Filho, Marie Laure Delignette-Muller, Sandrine Charles

Journal of Theoretical Biology . 258 ( 3 ) : 380

DOI: 10.1016/j.jtbi.2008.07.029

Journal article

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Toxicity of ivermectin on cladocerans: comparison of toxic effects on daphnia and ceriodaphnia species

Christelle Lopes, Sandrine Charles, B. Vollat, J. Garric

Environmental Toxicology and Chemistry . 28(10) : 2160-2166

Journal article

see the publication

Matrix Population Models as Relevant Modeling Tools in Ecotoxicology

Sandrine Charles, E. Billoir, Christelle Lopes, Arnaud Chaumot

incollection . 2 : 261-298

Journal article

see the publication

Chronic effects of ivermectin on Daphnia magna and Ceriodaphnia dubia: between-species and between-strains comparisons

C. Lopes, S. Charles, Arnaud Chaumot, B. Vollat, Jeanne Garric

SETAC Europe 18th Annual Meeting . : 1

Poster

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Chronic effects of ivermectin chronic effects of ivermectin on daphnia magna and ceriodaphnia dubia: between-species and between-strains comparisons

C. Lopes, S. Charles, Arnaud Chaumot, B. Vollat, Jeanne Garric

SETAC Europe 18th Annual Meeting . : 1

Poster

see the publication

Statistical cautions when estimating DEBtox parameters

Elise Billoir, M.L. Delignette-Müller, A. Pery, Olivier Geffard, S. Charles

Journal of Theoretical Biology . 254 ( 1 ) : 55-64

DOI: 10.1016/j.jtbi.2008.05.006

Journal article

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An individual-based model to describe a Bullhead population dynamic including temperature variations

S. Charles, F. Subtil, J. Kielbassa, Didier Pont

Ecological Modelling . 215 : 377-392

Journal article

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Pollution, stochasticity and spatial heterogeneity in the dynamics of an age-structured population of brown trout living in a river network

Arnaud Chaumot, S. Charles, H.R. Akçakaya, J.D. Stark, T.S. Bridges

Demographic toxicity: Methods in ecological risk assessment . 978-0-19-533296-4 : 168-183

Book chapter

see the publication

Population Dynamics of Grayling: Modelling Temperature and Discharge Effects

Sandrine Charles, J.-P. Mallet, H. Persat

Mathematical Modelling of Natural Phenomena . 1 ( 1 ) : 31-48

DOI: 10.1051/mmnp:2006002

Journal article

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An individual-based model to describe a bullhead population dynamics including temperature variations

Sandrine Charles, F. Subtil, J. Kielbassa, D. Pont

Ecological Modelling . 215 : 377-392

Journal article

see the publication

Do vertically transmitted symbionts co-existing in a single host compete or cooperate? A modelling approach

E. Vautrin, S. Genieys, Sandrine Charles, F. Vavre

Journal of Evolutionary Biology . 21 : 145-161

Journal article

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Optimal release strategies for the biological control of aphids in melon greenhouses

Christelle Lopes, Thierry Spataro, Laurent Lapchin, Roger Arditi

Biological Control . 48 ( 1 ) : 12 - 21

DOI: 10.1016/j.biocontrol.2008.09.011

Journal article

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A bayesian approach to analyse ecotoxicological data

Elise Billoir, Marie Laure Delignette-Muller, Alexandre R.R. Pery, Sandrine Charles

Environmental Science and Technology . 42 ( 23 ) : 8978-8984

DOI: 10.1021/es801418x

Journal article

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Dynamic energy budget as a basis to model population-level effects of zinc-spiked sediments in the gastropod valvata piscinalis

Virginie Ducrot, A. Pery, R. Mons, H. Quéau, S. Charles, Jeanne Garric

Environmental Toxicology and Chemistry . 26 ( 8 ) : 1774-1783

Journal article

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Integrating the lethal and sublethal effects of toxic compounds into the population dynamics of Daphnia magna: A combination of the DEBtox and matrix population models

Elise Billoir, A. Pery, S. Charles

Ecological Modelling . 203 ( 3-4 ) : 204-214

DOI: 10.1016/j.ecolmodel.2006.11.021

Journal article

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Stochasticity and spatial heterogeneity in population dynamics: implications for ecotoxicological risk assessment

Arnaud Chaumot, Elise Billoir, S. Charles

SETAC Europe 17th Annual Meeting, Porto, Portugal, PRT, 20-24 May 2007 . : 1

Conference paper

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Evolution and invasion dynamics of multiple infections with Wolbachia investigated using matrix based models.

E. Vautrin, Sandrine Charles, S. Genieys, F. Vavre

Journal of Theoretical Biology . 245 : 197-209

Journal article

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An individual-based model for describing the bullhead population dynamics in a river network

S. Charles, F. Subtil, Didier Pont

The 6th european conference on ecological modelling ECEM 07, Trieste, ITA, 27-30 novembre 2007 . : 1

Conference paper

see the publication

An implicit approach to model plant infestation by insect pests

Christelle Lopes, Thierry Spataro, Christophe Doursat, Laurent Lapchin, Roger Arditi

Journal of Theoretical Biology . 248 ( 1 ) : 164 - 178

DOI: 10.1016/j.jtbi.2007.05.010

Journal article

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Dynamic energy budget as a basis to model population-level effects of zinc-spiked sediments in the gastropod Valvata piscinalis.

Virginie Ducrot, Alexandre R.R. Pery, R. Mons, H. Quéau, Sandrine Charles, J. Garric

Environmental Toxicology and Chemistry . 26 ( 8 ) : 1774-1783

DOI: 10.1897/06-556R.1

Journal article

see the publication

Integrating the lethal and sublethal effects of toxic compounds into the population dynamics of Daphnia magna : A combinaison of the DEBtox and matrix population models

E. Billoir, Alexandre R.R. Pery, Sandrine Charles

Ecological Modelling . 203 : 207-214

Journal article

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Dynamique d'un système hôte-parasitoïde en environnement spatialement hétérogène et lutte biologique Application au puceron Aphis gossypii et au parasitoïde Lysiphlebus testaceipes en serre de melons

Christelle Lopes

Thesis

see the publication

Population dynamics of grayling : modelling temperature and discharge effects.

S. Charles, J.P. Mallet, Henri Persat

Mathematical Modelling of Natural Phenomena . 1 ( 1 ) : 33-48

Journal article

see the publication