GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Segurel Laure

Chargée de recherche

CNRS

Address: 43 bd du 11 novembre 1918
69622 VILLEURBANNE cedex

Tel: 04 72 43 26 28

Email

Batiment Mendel, 2ème étage. Bureau 12.025

Broad research interests : I am a CNRS researcher in population genetics, broadly interested in using genetic data to understand species evolution, more specifically to investigate how species adapt to their environment. During my PhD at the Musée de l'Homme with E Heyer and R Vitalis (UMR7206 - Paris), I worked in anthropological genetics, to decipher how various cultural features (matrimonial rules, language) shape the genetic diversity in Central Asia. I further worked on identifying selective pressures on various metabolic genes involved in adaptation to diet in herders and farmers from Central Asia. During my post-doc at UChicago with M Przeworski, I studied how recombination evolved between humans and chimpanzees, and across human populations, and I looked for signatures of balancing selection in humans and chimpanzees genomes. I also investigated what are the different determinants of neutral genetic diversity, as well as the factors influencing mutation rates. Since I got recruited at the CNRS in 2013 (UMR7206 - Paris), I continued working on human adaptation to changes in diet by studying lactase persistence using both modern and ancient DNA. In parallel, I am interested in understanding how humans and their associated microbes are co-evolving. Specifically, I developed a project in Cameroon to better understand how the human gut (and oral) microbiota evolved in response to changes in human diet, especially linked to the growing urbanisation and industrialisation of human populations. I am currently working at the LBBE (UMR5558 - Lyon) and developing projects on balancing selection (a mode of adaptation that maintains genetic diversity), to study its prevalence and underlying mechanisms both in primates and in birds, which have contrasted recombination landscapes and effective population sizes.

 

Publications

Display of 31 to 45 publications on 45 in total

Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees

E. Leffler, Z. Gao, S. Pfeifer, L. Segurel, A. Auton, O. Venn...

Science . 339 ( 6127 ) : 1578-1582

DOI: 10.1126/science.1234070

Journal article

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Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia

Laure Ségurel, Frédéric Austerlitz, Bruno Toupance, Mathieu M. Gautier, Joanna L Kelley, Patrick Pasquet...

European Journal of Human Genetics . 21 ( 10 ) : 1146-1151

DOI: 10.1038/ejhg.2012.295

Journal article

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Different kinds of genetic markers permit inference of Paleolithic and Neolithic expansions in humans

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure Ségurel, Raphaëlle Chaix...

Conférence Jacques Monod .

Poster

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A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

A. Auton, A. Fledel-Alon, S. Pfeifer, O. Venn, L. Segurel, T. Street...

Science . 336 ( 6078 ) : 193-198

DOI: 10.1126/science.1216872

Journal article

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The ABO blood group is a trans-species polymorphism in primates

Laure L. Segurel, Emma E. E. E. Thompson, Timothée T. Flutre, Jessica J. Lovstad, Aarti A. Venkat, Susan W. S. W. Margulis...

Proceedings of the National Academy of Sciences of the United States of America . 109 ( 45 ) : 18493 - 18498

DOI: 10.1073/pnas.1210603109

Journal article

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Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

Ellen Miranda Leffler, Kevin Bullaughey, Daniel R Matute, Wynn Meyer, Laure Ségurel, Aarti A. Venkat...

PLoS Biology . 10 ( 9 ) : e1001388

DOI: 10.1371/journal.pbio.1001388

Journal article

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Lactase persistence in central Asia: phenotype, genotype, and evolution.

Evelyne Heyer, Lionel Brazier, Laure Ségurel, Tatiana Hegay, Frédéric Austerlitz, Lluis Quintana-Murci...

Human Biology . 83 ( 3 ) : 379-92

DOI: 10.3378/027.083.0304

Journal article

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The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

Laure Ségurel, Ellen Miranda Leffler, Molly M. Przeworski

PLoS Biology . 9 ( 12 ) : e1001211

DOI: 10.1371/journal.pbio.1001211

Journal article

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In the heartland of Eurasia: the multilocus genetic landscape of Central Asian populations

Evelyne Heyer, Begoña Martínez-Cruz, Renaud Vitalis, Laure Ségurel, Frédéric Austerlitz, Myriam Georges...

European Journal of Human Genetics .

DOI: 10.1038/ejhg.2010.153

Journal article

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Mode de vie et diversité génétique dans les populations humaines d'Asie Centrale

Laure Ségurel

Thesis

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Frequency of the AGT Pro11Leu polymorphism in humans: Does diet matter?

Laure Ségurel, Sophie Lafosse, Evelyne Heyer, Renaud Vitalis

Annals of Human Genetics . 74 ( 1 ) : 57-64

DOI: 10.1111/j.1469-1809.2009.00549.x

Journal article

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Looking for signatures of sex-specific demography and local adaptation on the X chromosome.

Evelyne Heyer, Laure Segurel

Genome Biology . 11 ( 1 ) : 203

DOI: 10.1186/gb-2010-11-1-203

Journal article

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Genetic diversity and the emergence of ethnic groups in Central Asia

Evelyne Heyer, Patricia Balaresque, Mark Jobling, Lluis Quintana-Murci, Raphaelle Chaix, Laure Segurel...

BMC Genetics . 10 ( 1 ) : 49

DOI: 10.1186/1471-2156-10-49

Journal article

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Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study.

Laure Ségurel, Begoña Martínez-Cruz, Lluis Quintana-Murci, Patricia Balaresque, Myriam Georges, Tatiana Hegay...

PLoS Genetics . 4 ( 9 ) : e1000200

DOI: 10.1371/journal.pgen.1000200

Journal article

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