Computing services

Members

 

info@listes-lbbe.univ-lyon1.fr

 

 

The "Pôle informatique" (hereafter called "PI") is constituted of 9 engineers (1T, 5IE, 3IR). Our activities are distributed among three main directions: computing and storage infrastructure management (shared resources, and invidual equipment), software and service development and data analysis in molecular biology and ecology.

Infrastructures managment

  • Microcomputing: the PI is in charge of managing the laboratory's microcomputer equipment, from choosing the most appropriate solution in consultation with the future user to managing maintenance, including installation and configuration of the equipment.
  • Laboratory Information System: the PI provides laboratory and community members with a number of services, including several web servers (apache), numerous database servers (relational or indexed) and several collaborative tools (Git, Redmine, Seafile...). These services are hosted on largely virtualized machines.
Cluster de calcul UMR5558/PRABI
  • Compute and storage: since 2009, the PI manages a computing cluster with almost 1200 avalaible computing cores. The cluster is linked to a 600 TB high performing distributed storage system under BeeGFS and an object mode storage based on iRods (~400 useful TB).
  • Cloud and containerization: cloud-girofle (224 vcpu and 120 To), the local cloud operated by the PI since 2017, is part of the Biosphere cloud federation from the French Institute of Bioinformatics (IFB). We are starting to converge our virtualization infrastructure towards containerization technologies (docker, singularity).  
  • User support: the PI provides user support for all the resources and tools available to the laboratory's members. It trains and supports users in their use of shared resources through trainingsessions, information and monitoring meetings and mailing lists.

Software and methodological development

Members of the PI are involved in numerous software development projects in collaboration with the lab researchers, covering a large range of programming languages (R, Python, C++, OCaml, Javascript, SQL, shell). It goes from optimized parallel numerical codes to web services and dedicated databases (SQL or no-SQL). A peculiar effort is also performed to share the best practices of modern software development and make these software codes reproducible and available following the standards and requirements of the community.

Data analysis

Members of the PI are in the front line facing the data avalanche (and the data diversity) of this decade.
A large part of our activity is related to the quantity of data coming from sequencing technologies. The PI develops and proposes pipelines for genomic data assembly and annotation, RNA-seq and RAD-seq data analysis. More recently, computer image processing has become an important issue for future ecological studies performed in the lab in the Evolutionary Ecology.

Animation, training and scientific expertise

Our group has set up a series of dedicated workshops  to improve internal skills in software engineering, distributed computing, programming and data analysis, which complements more formal teaching sessions. Members of the group are also involved in training activities in universities (UCBL1) and CNRS (Formation permanente).
In their respective fields, members of the PI actively monitor technological developments and participate in major events such as JOBIM (bioinfo), the JRES (system administration), the JDEV (development), the Aramis days (system and network administration and software development) and the 'Rencontres R' (programmation). The PI is also involved in dedicated networks and/or projects of national scope such as the LyonCalcul group, the RLyon group and the IFB-NNCR and IFB-Core projects.

We works in close cooperation with the bioinformatics platform PRABI (Pôle Rhône-Alpes de BioInformatique), notably for the management of the computing and storage infrastructure, the diffusion of our lab's software production, the organization of teaching sessions and for sharing expertise in genomic/transcriptomic data analysis.

Poster

Publications

Display of 31 to 60 publications on 153 in total

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

Van Thu Nguyen, Philippe Riviere, Pierre Ripoll, Julien Barnier, Romain Vuillemot, Gabriel Ferrand...

Journal of Clinical Epidemiology . ( 130 ) : 107-116

DOI: 10.1016/j.jclinepi.2020.10.010

Journal article

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DILS: Demographic inferences with linked selection by using ABC

Christelle Fraïsse, Iva Popovic, Clément Mazoyer, Bruno Spataro, Stephane Delmotte, Jonathan Romiguier...

Molecular Ecology Resources .

DOI: 10.1111/1755-0998.13323

Journal article

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Lifespan decreases with proportion of sons in males but not females of zoo‐housed tigers and lemurs

Morgane Tidière, Guillaume Douay, Peter Müller, Aurélie Siberchicot, Alexander Sliwa, Mylisa Whipple...

Journal of Evolutionary Biology .

DOI: 10.1111/jeb.13793

Journal article

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Sex‐specific actuarial and reproductive senescence in zoo‐housed tiger ( Panthera tigris ): The importance of sub‐species for conservation

Morgane Tidière, Peter Müller, Alexander Sliwa, Aurélie Siberchicot, Guillaume Douay

Zoo Biology .

DOI: 10.1002/zoo.21610

Journal article

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Anticoagulation prior to hospitalization is a potential protective factor for COVID-19: insight from a French multicenter cohort study

Richard Chocron, Vincent Galand, Joffrey Cellier, Nicolas Gendron, Thibaut Pommier, Olivier Bory...

Journal of the American Heart Association . 10 ( 8 ) : e018288

DOI: 10.1161/JAHA.120.018624

Journal article

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Who benefits most from Lyon’s bike sharing system?

Jordan Cambe, Patrice Abry, Julien Barnier, Pierre Borgnat, Marie Vogel, Pablo Jensen

PLoS ONE . 15 ( 4 )

DOI: 10.1371/journal.pone.0231550

Journal article

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Treerecs: an integrated phylogenetic tool, from sequences to reconciliations.

Nicolas Comte, Benoît Morel, Damir Hasic, Laurent Guéguen, Bastien Boussau, Vincent Daubin...

Bioinformatics . 36 ( 18 ) : 4822-4824

DOI: 10.1093/bioinformatics/btaa615

Journal article

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Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates

Rylan Shearn, Alison E Wright, Sylvain Mousset, Corinne Régis, Simon Penel, Jean-François Lemaître Lemaître...

eLife . 9

DOI: 10.7554/eLife.63650

Journal article

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Evolutionary plasticity of mating-type determination mechanisms in Paramecium aurelia sibling species

Natalia Sawka-Gądek, Alexey Potekhin, Deepankar Pratap Singh, Inessa Grevtseva, Olivier Arnaiz, Simon Penel...

Genome Biology and Evolution . ( evaa258 )

DOI: 10.1093/gbe/evaa258

Journal article

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Revisiting giraffe photo-identification using deep learning and network analysis

Vincent Miele, Gaspard Dussert, Bruno Spataro, Simon Chamaillé-Jammes, Dominique Allainé, Christophe Bonenfant

DOI: 10.1101/2020.03.25.007377

Preprint

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Studying genetic antagonisms as drivers of genome evolution

Mathieu Joron, Rylan Shearn, Alison E Wright, Sylvain Mousset, Corinne Régis, Simon Penel...

Peer Community In Evolutionary Biology .

DOI: 10.24072/pci.evolbiol.100108

Journal article

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Evolutions of Individuals Use of Lyon's Bike Sharing System

Jordan Cambe, Patrice Abry, Julien Barnier, Pierre Borgnat, Marie Vogel, Pablo Jensen

Preprint

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IFB-Biosphère : Services cloud pour l'analyse des données des sciences de la vie

Christophe Blanchet, Olivier Collin, Matéo Boudet, Stéphane Delmotte, Hervé Gilquin, Jean-François Guillaume...

Journées RESeaux - JRES 2019 .

Conference paper

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Pollen limitation as a main driver of fruiting dynamics in oak populations

Marie-Claude Bel-Venner, David Fouchet, Aurélie Siberchicot, Vincent Boulanger, Thomas Caignard, Michel Thibaudon...

Ecology Letters . 22 ( 1 ) : 98-107

DOI: 10.1111/ele.13171

Journal article

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Detecting adaptive convergent amino acid evolution

Carine Rey, Vincent Lanore, Philippe Veber, Laurent Guéguen, Nicolas Lartillot, Marie Sémon...

Philosophical Transactions of the Royal Society B: Biological Sciences . 374 ( 1777 ) : 1-11

DOI: 10.1098/rstb.2018.0234

Journal article

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Pollen limitation as a main driver of fruiting dynamics in oak populations

Éliane Schermer, Marie‐claude Bel‐venner, David Fouchet, Aurélie Siberchicot, Vincent Boulanger, Thomas Caignard...

Ecology Letters . 22 ( 1 ) : 98-107

DOI: 10.1111/ele.13171

Journal article

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questionr

Julien Barnier, François Briatte, Joseph Larmarange

Software

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Gearing up to handle the mosaic nature of life in the quest for orthologs

Kristoffer Forslund, Cécile Pereira, Salvador Capella-Gutiérrez, Alan Sousa da Silva, Adrian M Altenhoff, Jaime Huerta-Cepas...

Bioinformatics . 34 ( 2 ) : 323-329

DOI: 10.1093/bioinformatics/btx542

Journal article

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DRomics: A Turnkey Tool to Support the Use of the Dose–Response Framework for Omics Data in Ecological Risk Assessment

Floriane Larras, Elise Billoir, Vincent Baillard, Aurélie Siberchicot, Stefan Scholz, Tesfaye Wubet...

Environmental Science and Technology . 52 ( 24 ) : 14461-14468

DOI: 10.1021/acs.est.8b04752

Journal article

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Multivariate Analysis of Ecological Data with ade4

Jean Thioulouse, Stéphane Dray, Anne-Béatrice Dufour, Aurélie Siberchicot, Thibaut Jombart, Sandrine Pavoine

DOI: 10.1007/978-1-4939-8850-1

Book

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Maternal reproductive senescence shapes the fitness consequences of the parental age difference in ruffed lemurs

Morgane Tidière, Xavier Thevenot, Adamantia Deligiannopoulou, Guillaume Douay, Mylisa Whipple, Aurélie Siberchicot...

Proceedings of the Royal Society B: Biological Sciences . 285 ( 1886 ) : 20181479

DOI: 10.1098/rspb.2018.1479

Journal article

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MOSAIC : une plate-forme web pour l’analyse statistique des données d’écotoxicologie. Fiche Thématique N°13

Sandrine Charles, Virgile Baudrot, Philippe Veber

: 4 p.

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Persistent Interactions with Bacterial Symbionts Direct Mature-Host Cell Morphology and Gene Expression in the Squid-Vibrio Symbiosis

Natacha Kremer, Eric Koch, Adil El Filali, Lawrence Zhou, Elizabeth Heath-Heckman, Edward Ruby...

mSystems . 3 ( 5 )

DOI: 10.1128/mSystems.00165-18

Journal article

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MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

Aurélie Siberchicot, Adrien Bessy, Laurent Gueguen, Gabriel A. B. Marais

Genome Biology and Evolution . 9 ( 10 ) : 2506-2509

DOI: 10.1093/gbe/evx178

Journal article

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adegraphics: An S4 Lattice-Based Package for the Representation of Multivariate Data

Aurélie Siberchicot, A. Julien-Laferrière, Ab. Dufour, J. Thioulouse, S. Dray

The R Journal . 9 ( 2 ) : 198-212

DOI: 10.32614/RJ-2017-042

Journal article

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