COEVOL Multi-Scale Coevolution

Evolutionary Genetics of Interactions Group

Vavre Fabrice

Directeur de recherche

CNRS

Address: 43 bd du 11 novembre 1918
69622 VILLEURBANNE cedex

Tel: 33 04 72 43 19 21

Email

Who am we? Who are I?

These two strange questions perfectly define my research interests. I study interspecific relationships, anotably symbiotic interactions, using as a model the interactions between arthropods and bacteria with mainly vertical transmission (from mother to offspring). The objective is to understand the dynamics of this chimeric individual, the factors that orient these interactions towards conflict or cooperation, and their consequences on the extended phenotype of the individual and the evolution of each of the partners. The subtlety of these interactions, which continually navigate between selfish and shared interests, is particularly important to consider and integrate into the trendy study of the holobiont and the microbiota. This general theme is currently structured around 3 main projects:

Co-adaptation within holobionts. Within the framework of the ANR Hmicmac project, we are seeking, with Laurence Mouton, to test the hypothesis that host-microbiota interactions should lead to co-adaptation between partners. This hypothesis is tested using experimental evolution based on situations where these possible co-adaptations are initially broken and then left free to evolve again. This approach is being carried out on the whitefly Bemisia tabaci and its symbiotic bacteria at the LBBE, and will be compared with similar experiments carried out on the pea aphid. This project also involves the IGEPP (Rennes) and BF2I (Lyon) laboratories.

Response of symbioses to stress. Within the framework of the RESIST project (ANR JCJC, coord. Natacha Kremer, LBBE), we are seeking to test whether symbiosis is a driving force or a barrier to adaptation to new environmental stresses. We are using the association between Drosophila melanogaster and Wolbachia (wMelPop strain), which is subjected to punctual or chronic stresses with either a pro-oxidant agent (the herbicide paraquat), or virus C, or both simultaneously.

Dynamics of obligate symbiotic interactions in ticks.  Within the framework of the MICROM project (ANR, coord. O. Duron, MIVEGEC), we are seeking to understand the whys and wherefores of recurrent replacements of obligate nutritional symbionts in ticks. Indeed, these strict haematophagous arthropods depend on nutritional symbionts providing them with B vitamins. However, multiple replacement events have occurred during tick evolution. Future work at the LBBE will be dedicated to comparative genomics of symbionts from different tick species.

Finally, within the framework of several projects (SBP MicroBeHave, 2 CIFRE theses, an ANR and a project), we have developed with Julien Varaldi and Natacha Kremer, in collaboration with the BF2I laboratory and the company Izinovation, a new project on  bedbugs, a re-emerging pest due to its resistance to insecticides, strictly haematophagous and totally dependent on symbionts of the Wolbachia genus for the supply of B vitamins. Our work seeks to characterise the genetic mechanisms of resistance and to better understand the genetic and metabolic dialogue between the insect and its symbiont.

Development of "One Health" approaches in Lyon

In addition to these scientific aspects, I am also involved in the construction of the research ecosystem in Lyon  on One Health approaches. This has led me to lead the Symbiotron platform project for more than 10 years, and since 2021 to coordinate the recently funded Equipex+ Infectiotron project led by the University of Lyon 1. This project seeks to develop a set of coordinated tools for the operational development of projects on infectious diseases from their natural environment to the laboratory, with a particular focus on level 3 pathogens. I am also actively involved in the implementation and development of the SHAPE-Med@Lyon project, also led by the University of Lyon 1, and in particular for the development of the Lyon Transdisciplinary Health Institute.

Publications

Display of 61 to 90 publications on 101 in total

Maintenance of adaptive differentiation by Wolbachia induced bidirectional cytoplasmic incompatibility: the importance of sib-mating and genetic systems.

Antoine Branca, Fabrice Vavre, Jean-François Silvain, Stéphane Dupas

BMC Evolutionary Biology . 9 : 185

DOI: 10.1186/1471-2148-9-185

Journal article

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Drosophila-parasitoid communities as model systems for host-Wolbachia interactions.

Fabrice Vavre, Laurence Mouton, Bart A Pannebakker

Advances in Parasitology . 70 : 299-331

DOI: 10.1016/S0065-308X(09)70012-0

Journal article

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Infecciones múltiples regulación y evolución de poblaciones simbióticas

F. Vavre, E. Vautrin, G. Gueguen, L. Mouton, Frédéric Fleury

incollection . -- : 197-226

Journal article

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Drosophila–Parasitoid Communities as Model Systems for Host–Wolbachia Interactions

F. Vavre, L. Mouton, B.A. Pannebakker

incollection . 70 : 229-331

Journal article

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Wolbachia interferes with ferritin expression and iron metabolism in insects.

Natacha Kremer, Denis Voronin, Delphine Charif, Patrick Mavingui, Bertrand Mollereau, Fabrice Vavre

PLoS Pathogens . 5 ( 10 ) : e1000630

DOI: 10.1371/journal.ppat.1000630

Journal article

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Interactions between vertically transmitted symbionts: cooperation or conflict ?

E. Vautrin, F. Vavre

Trends in Microbiology . 17 : 95-99

Journal article

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Evolution des interactions symbiotiques chez les insectes : A quel niveau de sélection se vouer ?

F. Vavre

incollection . -- : 33-35

Journal article

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Eviter les tricheurs: mode de transmission et stabilité des symbioses

F. Vavre

Biofutur . 299 : 33-35

Journal article

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Inherited intracellular ecosystem: symbiotic bacteria share bacteriocytes in whiteflies

Y. Gottlieb, M. Ghanim, G. Gueguen, S. Kontsedalov, F. Vavre, Frédéric Fleury...

FASEB Journal . 22 : 1-9

Journal article

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Do vertically transmitted symbionts co-existing in a single host compete or cooperate? A modelling approach

E. Vautrin, S. Genieys, Sandrine Charles, F. Vavre

Journal of Evolutionary Biology . 21 : 145-161

Journal article

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Intense transpositional activity of insertion sequences in an ancient obligate endosymbiont

R. Cordaux, S. Pichon, A. Ling, P. Perez, C. Delaunay, F. Vavre...

Molecular Biology and Evolution . 25 ( 9 ) : 1889-1896

DOI: 10.1093/molbev/msn134

Journal article

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Is symbiosis evolution influenced by the pleiotropic role of programmed cell death in immunity an development ?

F. Vavre, N. Kremer, B.A. Pannebakker, B. Loppin, Patrick Mavingui

Insect Symbiosis . 3 : 57-76

Book chapter

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Parasitic inhibition of cell death facilitates symbiosis.

Bart A Pannebakker, Benjamin Loppin, Coen P H Elemans, Lionel Humblot, Fabrice Vavre

Proceedings of the National Academy of Sciences of the United States of America . 104 ( 1 ) : 213-5

DOI: 10.1073/pnas.0607845104

Journal article

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Tomato yellow leaf curl virus transmission efficacy is determined by symbiotic bacteria in the vector the sweet potato whitefly Bemisia tabaci

E. Zchori-Fein, Y.. Gottlieb, H. Czosnek, E. Chiel, F. Vavre, Frédéric Fleury...

Entomological Research . 37(1) : A42-A43

Journal article

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A Survey of the Bacteriophage WO in the Endosymbiotic Bacteria Wolbachia

L. Gavotte, H. Henri, R. Stouthamer, D. Charif, S. Charlat, M. Boulétreau...

Molecular Biology and Evolution . 24 : 427-435

Journal article

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Evolution and invasion dynamics of multiple infections with Wolbachia investigated using matrix based models.

E. Vautrin, Sandrine Charles, S. Genieys, F. Vavre

Journal of Theoretical Biology . 245 : 197-209

Journal article

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Interaction between host genotype and environmental conditions affects bacterial density in Wolbachia symbiosis

L. Mouton, H. Henri, D. Charif, M. Boulétreau, F. Vavre

Biology Letters . 3 : 210-213

Journal article

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Effect of temperature on Wolbachia density and impact on cytoplasmic incompatibility

L. Mouton, H. Henri, M. Boulétreau, F. Vavre

Parasitology . 132 : 49-56

Journal article

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Multiple infections and diversity of cytoplasmic incompatibility in a haplodiploid species

L. Mouton, H. Henri, M. Boulétreau, F. Vavre

Heredity . 94 : 187-192

Journal article

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An efficient procedure for purification of the obligate intracellular Wolbachia pipientis and representative amplification of its genome by multiple displacement amplification

Patrick Mavingui, Van Tran Van, Estelle Labeyrie, Edwige Rancès, Fabrice Vavre, Pascal Simonet

Applied and Environmental Microbiology . 71 : 6910-6917

Journal article

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Wolbachia requierement for oogenesis : occurence within the genus Asobara (Hynoptera, Braconidae) and evidence for intraspecific variation in A. tabida.

F. Dedeine, F. Vavre, M. Bouletreau

Heredity . 95 : 394-400

Journal article

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Wolbachia requirement for oogenesis: occurrence within the genus Asobara (Hymenoptera Braconidae) and evidence for intraspecific variation in A. tabida

F. Dedeine, M. Boulétreau, F. Vavre

Heredity . -- : 267-282

Journal article

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Efficient procedure for purification of obligate intracellular Wolbachia pipientis and representative amplification of its génome by multiple-pisplacement amplification

Patrick Mavingui, Van Tran Van, Estelle Labeyrie, Edwige Rancès, Fabrice Vavre, Pascal Simonet

Applied and Environmental Microbiology . 71 ( 11 ) : 6910-6917

DOI: 10.1128/AEM.71.11.6910-6917.2005

Journal article

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Virulence multiple infections and regulation of symbiotic population in the Wolbachia-Asobara tabida symbiosis

L. Mouton, F. Dedeine, H. Henri, M. Boulétreau, N. Profizi, F. Vavre

Genetics . 168 : 181-189

Journal article

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Cytogenetic mechanism and genetic consequences of thelytoky in the wasp Trichogramma cacoeciae

F. Vavre, J.H. de Jong, R. Stouthamer

Heredity . 93 : 592-596

Journal article

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Diversity distribution and specificity of WO phage infection in Wolbachia of four insect species

L. Gavotte, F. Vavre, H. Henri, M. Ravallec, R. Stouthamer, M. Boulétreau

Insect Molecular Biology . 13 : 147-153

Journal article

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Intra-individual coexistence of a Wolbachia strain required for host oogenesis with two strains inducing cytoplasmic incompatibility in the wasp Asobara tabida

F. Dedeine, F. Vavre, D.D. Shoemaker, M. Boulétreau

Evolution - International Journal of Organic Evolution . 58 : 2167-2174

Journal article

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Strain-specific regulation of intracellular Wolbachia density in multiply infected insects

L. Mouton, H. Henri, M. Boulétreau, F. Vavre

Molecular Ecology . 12 : 3459-3465

Journal article

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Between- and within-host species selection on cytoplasmic incompatibility-inducing Wolbachia in haplodiploids

F. Vavre, P. Fouillet, Frédéric Fleury

Evolution - International Journal of Organic Evolution . 57 : 421-427

Journal article

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