GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Duret Laurent

Directeur de recherche

CNRS

Address: 69622 VILLEURBANNE cedex
69622 VILLEURBANNE cedex

Tel: 33 04 72 44 62 97

Email

Batiment Mendel 2eme étage. Bureau 12.025

Genomes are the product of various evolutionary processes: certain genomic traits that we observe today reflect functional constraints that currently operate or that have operated in the past; others result from non-adaptive processes. To identify the features of the genome that are important for its functioning, it is necessary to look for features whose mode of evolution deviates from the neutralist model: this is the basic principle of the comparative analysis of genomes, which is at the heart of all my research activity. My work follows a double logic: study the evolution of genomes to better understand how they work - and vice versa, take into account the molecular mechanisms of genome functioning in order to better interpret sequence evolution. We explore genetic diversity at different level, both across species and within species (population genomics). My work is based on bioinformatic and statistical analysis of sequences, but also relies heavily on close collaborations with ‘wet-lab' biologists.
These last years, my main focus has been on exploring the consequences of homologous recombination on genome evolution. In particular, we have discovered that in many species, recombination induces non-Mendelien inheritance, favoring the fixation of GC-alleles (gBGC – for GC-Biased Gene Conversion). This non-adaptive process has a major impact on the evolution of genomic landscapes and also on gene expression processes. We are now trying to understand how and why does gBGC evolve, and how and why do recombination rates vary in space (along chromosomes) and in time (across species).
I am also interested in understanding how the constraints imposed by the cost of gene expression shape genome evolution. We have shown that gene expression level is an important determinant of selective pressures acting on numerous features: on protein sequences, on gene dosage, on splicing accuracy, and on translation efficiency. We are now exploring how variation in the efficacy of selection contributes to the evolution of the complexity of gene expression patterns across species.
I am also working, in collaboration with researchers from Paris and Gif, on the genomics of Paramecia. This unicellular eukaryote displays many very peculiar features that make it a fantastic model to explore  various topics (whole genome duplications, proliferation of selfish genetic elements, alternative splicing, transgenerational inheritance of epigenetic modifications, …).

 

Publications

Display of 91 to 120 publications on 173 in total

Evolutionary origin and maintenance of coexpressed gene clusters in mammals.

M. Sémon, L. Duret

Molecular Biology and Evolution . 23 : 1715-1723

Journal article

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Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia.

Jean-Marc Aury, Olivier Jaillon, L. Duret, Benjamin Noel, Claire Jubin, Betina M Porcel...

Nature . 444 ( 7116 ) : 171-8

DOI: 10.1038/nature05230

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The GC Content of Primates and Rodents Genomes Is Not at Equilibrium : a Reply to Antezana

L. Duret

Journal of Molecular Evolution . -- : 803-806

Journal article

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Integr8 and Genome Reviews: integrated views of complete genomes and proteomes.

P. Kersey, L. Bower, L. Morris, A. Horne, R. Petryszak, C. Kanz...

Nucleic Acids Research . 33 ( Database issue ) : D297-302

DOI: 10.1093/nar/gki039

Journal article

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Homology-dependent methylation in primate repetitive DNA.

J. Meunier, A. Khelifi, V. Navratil, L. Duret

Proceedings of the National Academy of Sciences of the United States of America . 102 ( 15 ) : 5471-6

DOI: 10.1073/pnas.0408986102

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Natural history of the ERVWE1 endogenous retroviral locus

B. Bonnaud, J. Beliaeff, O. Bouton, G. Oriol, L. Duret, Frédéric Mallet

Retrovirology . 2 : 1-7

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Relationship between gene expression and GC-content in mammals: statistical significance and biological relevance

M. Sémon, Dominique Mouchiroud, L. Duret

Human Molecular Genetics . 14 : 421-427

Journal article

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HOPPSIGEN: a database of human and mouse processed pseudogenes.

A. Khelifi, L. Duret, Dominique Mouchiroud

Nucleic Acids Research . 33 ( Database issue ) : D59-66

DOI: 10.1093/nar/gki084

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Tree pattern matching in phylogenetic trees: automatic search for orthologs or paralogs in homologous gene sequence databases.

Jean-François Dufayard, L. Duret, Simon Penel, Manolo Gouy, F. Rechenmann, G. Perrière

Bioinformatics . 21 ( 11 ) : 2596-603

DOI: 10.1093/bioinformatics/bti325

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Les trésors cachés du génome humain

L. Duret

Pour la science . -- : 16-21

Journal article

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Polymorphix: a sequence polymorphism database

E. Bazin, L. Duret, Simon Penel, N. Galtier

Nucleic Acids Research . 33 : 481-484

Journal article

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Bioinformatics with a French accent

L.D. Hurst, L. Duret

Genome Biology . 6 : 349.1-349.3

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Natural history of the ERVWE 1 endogenous retroviral locus.

Bertrand Bonnaud, Jean Beliaeff, Olivier Bouton, Guy Oriol, Laurent Duret, François Mallet

Retrovirology . 2:57 : 1 - 7

DOI: 10.1186/1742-4692-2-57

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The Decline of Isochores in Mammals: An Assessment of the GC Content Variation Along the Mammalian Phylogeny

E. Belle, L. Duret, N. Galtier, A. Eyre-Walker

Journal of Molecular Evolution . 58 : 653-660

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Identitag a relational database for SAGE tag identification and interspecies comparison of SAGE libraries

C. Keime, F. Damiola, Dominique Mouchiroud, L. Duret, Olivier Gandrillon

BMC Bioinformatics . 5 : 1-12

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ROSO : Research on Optimized Oligonucleotide Probes for Microarrays

N. Reymond, H. Charles, L. Duret, Federica Calevro, G. Beslon, J.-M. Fayard

Bioinformatics . 20 : 271-273

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Grid as a bioinformatic tool

N. Jacq, Christophe Blanchet, C. Combet, E. Cornillot, L. Duret, K. Kurata...

Parallel Computing . 30 : 1093-1107

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Identitag, a relational database for SAGE tag identification and interspecies comparison of SAGE libraries.

Céline Keime, Francesca Damiola, Dominique Mouchiroud, Laurent Duret, Olivier Gandrillon

BMC Bioinformatics . 5 : 143

DOI: 10.1186/1471-2105-5-143

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The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology

Frédéric Mallet, O. Bouton, S. Prudhomme, V. Cheynet, G. Oriol, B. Bonnaud...

Proceedings of the National Academy of Sciences of the United States of America . 101 : 1731-1736

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Evidence that functional transcription units cover at least half of the human genome

M. Sémon, L. Duret

Trends in Genetics . 20 : 229-232

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Recombination drives the evolution of GC-content in the human genome

J. Meunier, L. Duret

Molecular Biology and Evolution . 21 : 984-990

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Evidence of Selection on the Domesticated ERVWE1 env Retroviral Element Involved in Placentation

B. Bonnaud, O. Bouton, G. Oriol, V. Cheynet, L. Duret, Frédéric Mallet

Molecular Biology and Evolution . 21 : 1895-1901

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Identitag, a relational database for SAGE tag identification and interspecies comparison of SAGE libraries.

C. Keime, F. Damiola, D. Mouchiroud, L. Duret, O. Gandrillon

BMC Bioinformatics . ( 5 ) : 143

Journal article

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Physical and transcript map of the autosomal dominant colobomatous microphthalmia locus on chromosome 15q12-q15 and refinement to a 4.4 Mb region.

Laetitia Michon, Laurette Morlé, Muriel Bozon, L. Duret, Jean-Christophe Zech, Jacqueline Godet...

European Journal of Human Genetics . 12 ( 7 ) : 574-8

DOI: 10.1038/sj.ejhg.5201197

Journal article

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Grid as a bioinformatic tool

N. Jacq, Christophe Blanchet, C. Combet, E. Cornillot, L. Duret, K. Kurata...

Parallel Computing . 30 : 1093-1107

Journal article

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Physical and transcript map of the autosomal dominant colobomatous microphthalmia locus on chromosome 15q12-q15 and refinement to a 4.4 Mb region.

Laurent Michon, L. Morle, M. Bozon, L. Duret, Zech J. C., J. Godet...

European Journal of Human Genetics . ( 12 ) : 574-578

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Neutral effect of recombination on base composition in Drosophila

Gabriel Marais, Dominique Mouchiroud, L. Duret

Genetical Research . 81 : 79-89

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Placenta-Specific INSL4 Expression Is Mediated by a Human Endogenous Retrovirus Element

I. Bièche, A. Laurent, I. Laurendeau, L. Duret, Y. Giovangrandi, J.L. Frendo...

Biology of Reproduction . 68 : 1422-1429.

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