Evolutionary Ecology

Quantitative and Evolutionary Ecology of Communities Group

Delignette-Muller Marie-Laure

Professeure des universités

VetAgro-Sup

Address: 69280 MARCY L'ÉTOILE

Tel: 33 04 72 43 27 56

Email

I am a Professor at VetAgro Sup, responsible for various modules of biostatistics at the veterinary curriculum, a module of critical reading of articles. Some of my teaching documents are available on my personal web page.

My research activity is in the field of biometrics. I develop models and inference methods in the context of risk assessment in the field of health and environmental risks. My objective is to propose models/methods useful to researchers to better understand risks, and useful to managers to define risk indicators. My areas of expertise are: hierarchical models, non-linear models, dose-response models, in particular dose-response modeling of omics data, Bayesian inference.

In order to facilitate the use of the methods I develop to the largest number of people, I am involved in the development of various R packages: fitdistrplus, nlstools, DRomics.

My publications are listed exhaustively on my Google Scholar profile and my most recent papers are available on my HAL CV.

Publications

Display of 1 to 30 publications on 133 in total

Cluefish: mining the dark matter of transcriptional data series with over-representation analysis enhanced by aggregated biological prior knowledge

Ellis Franklin, Elise Billoir, Philippe Veber, Jérémie Ohanessian, Marie Laure Delignette-Muller, Sophie Martine Prud’homme

NAR Genomics and Bioinformatics . 7 ( 3 ) : lqaf103

DOI: 10.1093/nargab/lqaf103

Journal article

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Exploring transcriptomic data with over-representation analysis enhanced by aggregated biological prior knowledge

Ellis Franklin, Elise Billoir, Philippe Veber, Jérémie Ohanessian, Marie Laure Delignette-Muller, Sophie Prud'Homme

35th Society of Environmental Toxicology and Chemistry (SETAC 2025) .

Conference paper

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Environmental radioactivity impacts bioenergetic in tree frog of Fukushima

Lea Dasque, Damien Roussel, Jean-Marc Bonzom, Olivier Armant, Clément Car, Kenji Nanba...

Environmental Pollution . : 127147

DOI: 10.1016/j.envpol.2025.127147

Journal article

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Harmonisation of the diagnostic performances of serological ELISA tests for C. burnetii in ruminants in the absence of a gold standard: Optimal cut-offs and performances reassessment

Laureline Rivière, Elodie Rousset, Elsa Jourdain, Marie-Laure Delignette-Muller, Thibaut Lurier

Preventive Veterinary Medicine . 239 : 106509

DOI: 10.1016/j.prevetmed.2025.106509

Journal article

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From dose-response modelling of transcriptomic data to biological interpretation: an application to embryonic exposure of zebrafish (Danio rerio) to di-n-butyl phthalate (DBP)

Ellis Franklin, Elise Billoir, Marie Laure Delignette-Muller, Sophie M Prud'Homme

22nd Pollutant Responses in Marine Organisms Symposium (PRIMO22) .

Poster

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Interests and constraints towards unravelling endocrine disruptors mechanisms using dose-response transcriptomic data: application to the impact of di-n-butyl phthalate on zebrafish

Ellis Franklin, Marie-Laure Delignette-Muller, Elise Billoir, Sophie Prud'Homme

22nd Pollutant Responses in Marine Organisms (PRIMO22) .

Conference paper

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Harmonisation of the diagnostic performances of serological ELISA tests for C. burnetii in ruminants: optimal positivity thresholds and performance reassessment

Laureline Rivière, Elodie Rousset, Elsa Jourdain, Marie Laure Delignette-Muller, T. Lurier

Preprint

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Protein expression patterns and activities of two metabolic enzymes (CS and LDH) highlight a disturbance in the metabolic pathways of tree frogs living in the Chernobyl Exclusion Zone

Luc Camoin, Lea Dasque, Damien Roussel, Clément Car, Stéphane Audebert, Samuel Granjeaud...

6th International Conference on Radioecology & Environmental Radioactivity .

Poster

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AOP in the context of radioecology: challenges and insights

Elizabeth Dufourcq-Sekatcheff, Loic Quevarec, Marie-Laure Delignette-Muller, Clément Car, Jean-Marc Bonzom, Rodolphe Gilbin...

ERPW2024 - European radiation protection week .

Conference paper

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Décrypter les mécanismes de reprotoxicité radio-induite chez l'amphipode Gammarus fossarum

Sandrine Frelon, Rémi Recoura-Massaquant, Marie-Laure Delignette-Muller, Jean-Charles Gaillard, Nicolas Dubourg, Jean-Marc Bonzom...

Société d'écotoxicologie fondamentale et appliquée (SEFA) .

Conference paper

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19. Colistin resistance in pigs – assessing the effectiveness of mitigation measures

Claire Chauvin, Elsa Coz, Eric Jouy, Marie-Laure Delignette-Muller, Agnès Perrin-Guyomard, Xavier Sauzea...

Animal. Science proceedings . 15 ( 4 ) : 268-269

DOI: 10.1016/j.anscip.2024.06.183

Journal article

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Response of a carnivore community to water management in a semi-arid savanna

Aïssa Morin, Olivier Gimenez, Lara L Sousa, Justin Seymour-Smith, Holly O'Donnell, Marie-Laure Delignette-Muller...

Biological Conservation . 299 : 110777

DOI: 10.1016/j.biocon.2024.110777

Journal article

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Deep dive into the chronic toxicity of tyre particle mixtures and their leachates

Paul Boisseaux, Cassandra Rauert, Pradeep Dewapriya, Marie Laure Delignette-Muller, Robyn Barrett, Lee Durndell...

Journal of Hazardous Materials . 466 : 133580

DOI: 10.1016/j.jhazmat.2024.133580

Journal article

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Modeling HepaRG metabolome responses to pyrrolizidine alkaloid exposure for insight into points of departure and modes of action

Estelle Dubreil, Keyvin Darney, Marie Laure Delignette-Muller, Audrey Barranger, Sylvie Huet, Kevin Hogeveen...

Journal of Hazardous Materials . 474 : 134721

DOI: 10.1016/j.jhazmat.2024.134721

Journal article

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Development, feeding, and sex shape the relative quantity of the nutritional obligatory symbiont Wolbachia in bed bugs

Marius Poulain, Elodie Rosinski, Hélène Henri, Séverine Balmand, Marie Laure Delignette-Muller, Abdelaziz Heddi...

Frontiers in Microbiology . 15 : 1386458

DOI: 10.3389/fmicb.2024.1386458

Journal article

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Coxiella burnetii within-and between-herd true seroprevalence assessment in domestic ruminants in France accounting for diagnostic uncertainty with latent class

T. Lurier, Florence Ayral, Carole Sala, Kristel Gache, Marie Laure Delignette-Muller, Elsa Jourdain...

SBED Conference 2024: Insights in Action .

Poster

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Harmonisation of the diagnostic performances of ELISA tests for C. burnetii antibodies in ruminants: optimal positivity thresholds and performance reassessment

Laureline Rivière, Elodie Rousset, Elsa Jourdain, Marie Laure Delignette-Muller, T. Lurier

SBED Conference 2024: Insights in Action .

Poster

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Evaluation using latent class models of the diagnostic performances of three ELISA tests commercialized for the serological diagnosis of Coxiella burnetii infection in domestic ruminants.

T. Lurier, Elodie Rousset, Patrick Gasqui, Carole Sala, Eric Morignat, Clément Claustre...

SBED Conference 2024: Insights in Action .

Conference paper

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Résistance à la colistine chez le porc - des mesures de maîtrise efficaces

Claire Chauvin, Elsa Coz, Eric Jouy, Marie Laure Delignette-Muller, Agnes Perrin-Guyomard, Xavier Sauzea...

56. Journées de la Recherche Porcine . 56 : 81-82

Conference paper

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Population transcriptogenomics highlights impaired metabolism and small population sizes in tree frogs living in the Chernobyl Exclusion Zone

Clément Car, André Gilles, Elen Goujon, Marie Laure Delignette-Muller, Luc Camoin, Sandrine Frelon...

BMC Biology . 21 ( 1 ) : 164

DOI: 10.1186/s12915-023-01659-2

Journal article

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Evolution of the proportion of colistin-resistant isolates in animal clinical Escherichia coli over time - A hierarchical mixture model approach

Elsa Coz, Eric Jouy, Géraldine Cazeau, Nathalie Jarrige, Claire Chauvin, Marie Laure Delignette-Muller

Preventive Veterinary Medicine . 213 : 105881

DOI: 10.1016/j.prevetmed.2023.105881

Journal article

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DRomics, a workflow to exploit dose-response omics data in ecotoxicology

Marie Laure Delignette-Muller, Aurélie Siberchicot, Floriane Larras, Elise Billoir

Peer Community Journal . 3 : e90

DOI: 10.24072/pcjournal.325

Journal article

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Diagnostic sérologique de la fièvre Q chez les petits ruminants : faut-il et comment prendre en compte l'imperfection des tests ?

Thibaut Lurier, Marie-Laure Delignette-Muller, Florence Ayral, Elsa Jourdain, Elodie Rousset

Webinaire, coanimé par l’UMT PSR « Pilotage de la Santé des Ruminants » et l’OMACAP « Observatoire des Maladies Caprines » .

Conference paper

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Deep learning in veterinary medicine, an approach based on CNN to detect pulmonary abnormalities from lateral thoracic radiographs in cats

Léo Dumortier, Florent Guépin, Marie Laure Delignette-Muller, C. Boulocher, Thomas Grenier

Scientific Reports . 12 ( 1 ) : 11418

DOI: 10.1038/s41598-022-14993-2

Journal article

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Strain- and serotype-dependent affinity of Shiga toxin-producing Escherichia coli for bovine milk fat globules

A. Bagel, Marie Laure Delignette-Muller, Christelle Lopez, V. Michel, Delphine Thevenot-Sergentet, Thomas Douellou

Journal of Dairy Science . 105 ( 11 ) : 8688-8704

DOI: 10.3168/jds.2022-21840

Journal article

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Assessment of the French colistin action plan

Elsa Coz, Eric Jouy, Géraldine Cazeau, Nathalie Jarrige, Agnes Perrin-Guyomard, Anne Hemonic...

Third International Conference AACTING: Quantification, Benchmarking and Stewardship of Veterinary Antimicrobial Usage .

Poster

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