Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 1 to 30 publications on 225 in total

A brief review on models for birds exposed to chemicals

Dominique Lamonica, Lison Charvy, Dave Kuo, Clémentine Fritsch, Michaël Coeurdassier, Philippe Berny...

Environmental Science and Pollution Research .

DOI: 10.1007/s11356-024-34628-5

Journal article

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Advancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)

Sylvain Slaby, Alain Geffard, Cédric Fisson, Matthieu Bonnevalle-Normand, Anne-Sophie Allonier-Fernandes, Rachid Amara...

Journal of Environmental Management . 358 : 120784

DOI: 10.1016/j.jenvman.2024.120784

Journal article

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Quantifying the relationship between observed variables that contain censored values using Bayesian error-in-variables regression

Peter Vermeiren, Sandrine Charles, Cynthia C. Muñoz

Preprint

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Bioaccumulation, organotropism and fate of cadmium in Gammarus fossarum exposed through dietary pathway

Ophélia Gestin, Olivier Geffard, Nicolas Delorme, Laura Garnero, Thomas Lacoue-Labarthe, Christelle Lopes

Journal of Hazardous Materials . 480 : 135965

DOI: 10.1016/j.jhazmat.2024.135965

Journal article

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Impacts des néonicotinoïdes sur la biodiversité

Laure Mamy, Stéphane Pesce, Wilfried Sanchez, Stéphanie Aviron, Carole Bedos, Philippe Berny...

Séminaire EcoScience .

Conference paper

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Impacts des néonicotinoïdes sur la biodiversité

Laure Mamy, Stéphane Pesce, Wilfried Sanchez, Stéphanie Aviron, Carole Bedos, Philippe Berny...

52ème congrès du Groupe Français de recherche sur les Pesticides .

Conference paper

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High performance computing and neural network in support of toxicokinetic-toxicodynamic modelling for the understanding of mixture effects

Virgile Baudrot, Thomas Kleiber, Sandrine Charles, Nina Cedergreen, André Gergs

SETAC Europe 34th Annual Meeting .

Poster

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Assessing viral freshwater hazard using a toxicokinetic model and Dreissena polymorpha

Julie Do Nascimento, Mélissa Palos Ladeiro, Isabelle Bonnard, Christophe Gantzer, Nicolas Boudaud, Christelle Lopes...

Environmental Pollution . 344 : 123420

DOI: 10.1016/j.envpol.2024.123420

Journal article

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Advancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)

Sylvain Slaby, Alain Geffard, Cédric Fisson, Matthieu Bonnevalle-Normand, Anne-Sophie Allonier-Fernandes, Rachid Amara...

Journal of Environmental Management . 358 : 120784

DOI: 10.1016/j.jenvman.2024.120784

Journal article

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Assimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum

Ophélia Gestin, Christelle Lopes, Nicolas Delorme, Laura Garnero, Olivier Geffard, Thomas Lacoue-Labarthe

Peer Community Journal . 4 : e51

DOI: 10.24072/pcjournal.426

Journal article

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Mechanistic Analysis of the Sub Chronic Toxicity of La and Gd in Daphnia Magna Based on TKTD Modelling and Synchrotron X-Ray Fluorescence Imaging

Marion Revel, Kadda Medjoubi, Sandrine Charles, Andrew Hursthouse, Susanne Heise

DOI: 10.2139/ssrn.4570452

Preprint

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Impacts of neonicotinoids on biodiversity: a critical review

Laure Mamy, Stéphane Pesce, Wilfried Sanchez, Stéphanie Aviron, Carole Bedos, Philippe Berny...

Environmental Science and Pollution Research . 31 ( 1 ) : 90-108

DOI: 10.1007/s11356-023-31032-3

Journal article

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A brief review on models for birds exposed to chemicals

Dominique Lamonica, Lison Charvy, Dave Kuo, Clémentine Fritsch, Michael Coeurdassier, Philippe Berny...

Preprint

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Editorial trend: adverse outcome pathway (AOP) and computational strategy — towards new perspectives in ecotoxicology

Damien Baudiffier, Karine Audouze, Olivier Armant, Sandrine Frelon, Sandrine Charles, Rémy Beaudouin...

Environmental Science and Pollution Research . 31 ( 5 ) : 6587-6596

DOI: 10.1007/s11356-023-30647-w

Journal article

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Modélisation mathématique et statistique pour l’évaluation du risque environnemental

Christelle Lopes

HDR

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Impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques

S. Leenhardt, L. Mamy, S. Pesce, W. Sanchez, J.A. Amichot, J. Artigas...

978-2-7592-3656-5 : 183 p.

Book

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A meta-analysis of ecotoxicological models used for plant protection product risk assessment before their placing on the market

Floriane Larras, Rémy Beaudouin, Sandrine Charles, Arnaud Chaumot, Céline Pelosi, Laure Mamy

11th European Modelling Workshop .

Conference paper

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Approches de modélisation pour évaluer les effets écotoxicologiques des pesticides : revue critique

Floriane Larras, Sandrine Charles, Arnaud Chaumot, Céline Pelosi, Morgane Le Gall, Laure Mamy...

51ème congrès du Groupe Français de recherche sur les Pesticides .

Poster

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Study of host-symbionts coevolution in the whitefly Bemisia tabaci: an experimental evolution approach

Hubert Charles, Hélène Henri, Zainab Belgaidi, Isabelle Rahioui, Karen Gaget, Sylvain Benhamou...

13e Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA) .

Conference paper

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Amphibians under scrutiny - When human-dominated landscape mosaics are not in full compliance with their ecological requirements

Sandrine Charles

Peer Community In Ecology .

DOI: 10.24072/pci.ecology.100504

Journal article

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The use of new approach methodologies for the environmental risk assessment of food and feed chemicals

Matteo Riccardo Di Nicola, Irene Cattaneo, Alexis Nathanail, Edoardo Carnesecchi, Maria Chiara Astuto, Melina Steinbach...

Current Opinion in Environmental Science & Health . 31 : 100416

DOI: 10.1016/j.coesh.2022.100416

Journal article

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Uptake, distribution, and elimination of selenite in earthworm Eisenia fetida at sublethal concentrations based on toxicokinetic model

Ruiping Wang, Shizhong Yue, Caide Huang, Zhiqiang Shen, Yuhui Qiao, Sandrine Charles...

Science of the Total Environment . 858 : 159632

DOI: 10.1016/j.scitotenv.2022.159632

Journal article

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The ATTAC guiding principles to openly and collaboratively share wildlife ecotoxicology data

Cynthia C. Muñoz, Sandrine Charles, Emily Mcvey, Peter Vermeiren

MethodsX . 10 ( 1 ) : 101987

DOI: 10.1016/j.mex.2022.101987

Journal article

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hb or not hb - When and why accounting for background mortality in toxicological survival models matters?

Julie Plantade, Virgile Baudrot, Sandrine Charles

MethodsX . 10 : 102114

DOI: 10.1016/j.mex.2023.102114

Journal article

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OneWater FAIR Data Platform : setting up a national FAIR water data platform and community

Sylvain Grellet, Isabelle Braud, Fanny Arnaud, Kenneth Maussang, Anne Laurent, Frédéric Huynh...

TERENO OZCAR 2023 - 2ème conférence internationale TERENO OZCAR . : 1-23

Conference paper

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Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum

Ophélia Gestin, Thomas Lacoue-Labarthe, Nicolas Delorme, Laura Garnero, Olivier Geffard, Christelle Lopes

Environment International . 171 : 107673

DOI: 10.1016/j.envint.2022.107673

Journal article

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Main conclusions and perspectives from the collective scientific assessment of the effects of plant protection products on biodiversity and ecosystem services along the land–sea continuum in France and French overseas territories

Stéphane Pesce, Laure Mamy, Wilfried Sanchez, Marcel Amichot, Joan Artigas, Stéphanie Aviron...

Environmental Science and Pollution Research .

DOI: 10.1007/s11356-023-26952-z

Journal article

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Integrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers

Audrey Catteau, Antoine Le Guernic, Mélissa Palos Ladeiro, Odile Dedourge-Geffard, Marc Bonnard, Isabelle Bonnard...

Journal of Environmental Management . 341 : 118049

DOI: 10.1016/j.jenvman.2023.118049

Journal article

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In Vivo Mercury (De)Methylation Metabolism in Cephalopods under Different p CO 2 Scenarios

Sophie Gentès, Antoine Minet, Christelle Lopes, Emmanuel Tessier, Claire Gassie, Remy Guyoneaud...

Environmental Science and Technology . 57 ( 14 ) : 5761-5770

DOI: 10.1021/acs.est.2c08513

Journal article

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