GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Flandrois Jean-Pierre

Professeur d'université émérite

UCBL

Address: 43 Bd du 11 novembre 1918
69622 VILLEURBANNE

Tel: 04 72 44 85 60

Email

Linkedin

My Research

Two flagship projects

BIBI-DB BIBI-DB is a taxonomy-hierarchized set of databases and oriented to facilitate the phylogeny of Archaea and Bacteria. Thanks to a web interface it allows the phylogenetic placement of unknown nucleic acid sequences (this may precede identification). RiboDB is a ribosomal protein database of Bacteria and Archaea freely searchable via the Internet. RiboDB construction process is versatile and can be used to construct proteins databases from freshly assembled and annotated genomes.

Applications

leBIBI is a web application used worldwide to identify bacteria in hospital laboratories, industrial, environmental.
The leBIBI and RiboDB databases are useful to classify more rigorously the Bacteria and Archaea and may highlight new pathogen species. Their use helps to explain the evolution of the microbial world. RiboDB will allow to improve the quality of diagnosis of infections. 

Ancient Ecosystems and stable isotopes

I am very pleased to cooperate since 2012 in some work Christophe Lecuyer and his team as a physiologist, biologist and physician. This topic is now a real scientific center of interest for me!

The first studies were on ancient climates reconstruction by using the informations recorded in bone and teeth of egyptian mummies but of course we get also informations on human and animal nutrition. 
Climate reconstruction may also be done outside egypt with other types of samples.

We were also proud to show that the hatching temperature of Oviraptosaurs were not so different from that of actual birds... 

 

Medical microbiology

This are works I have initiated or using datas that have been collected during my previous position as Head of the Microbiology Laboratory CH Lyon-Sud 1979-2013.

Publications

Display of 91 to 120 publications on 137 in total

Convenient Model To Describe the Combined Effects of Temperature and pH on Microbial Growth

L. Rosso, J.R. Lobry, S. Bajard, Jean-Pierre Flandrois

Applied and Environmental Microbiology . 61 : 610-616

Journal article

see the publication

Accuracy of microbial growth predictions with square root and polynomial models

Jean-Pierre Flandrois, M. Delignette-Muller

International Journal of Food Microbiology . 27 ( 2-3 ) : 139-146

DOI: 10.1016/0168-1605(94)00158-3

Journal article

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[Post-antibiotic effect of three aminoglycosides against Klebsiella pneumoniae].

M de Montclos, M. Guinet, Jean-Pierre Flandrois, Catherine Chapuis

Pathologie Biologie . 42 ( 5 ) : 419-24

Journal article

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An accurate diffusion method for determining bacterial sensitivity to antibiotics

M. Delignette-Muller, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 34 ( 1 ) : 73-81

DOI: 10.1093/jac/34.1.73

Journal article

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Mathematical model of the interactions between Micrococcus spp. and Pseudomonas aeruginosa on agar surface

J.-P. Flandrois, Catherine Chapuis

The Journal of applied bacteriology . 77 ( 6 ) : 727-732

DOI: 10.1111/j.1365-2672.1994.tb02826.x

Journal article

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An unexpected correlation between cardinal temperatures of microbial growth highlighted by a new model

L. Rosso, J.R. Lobry, Jean-Pierre Flandrois

Journal of Theoretical Biology . 162 : 447-463

Journal article

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Actinomyces pyogenes: susceptibility of 103 clinical animal isolates to 22 antimicrobial agents

V Guérin-Faublée, Jp Flandrois, E Broye, F Tupin, Y Richard

Veterinary Research . 24 ( 3 ) : 251-259

Journal article

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Mathematical model for comparison of time-killing curves.

F Guerillot, G. Carret, Jean-Pierre Flandrois

Antimicrobial Agents and Chemotherapy . 37 ( 8 ) : 1685-1689

DOI: 10.1128/AAC.37.8.1685

Journal article

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Antimicrobial susceptibility testing of actinomyces pyogenes: Comparison of disk diffusion test and Api ATB Strep system with the Agar dilution method

Véronique Guérin-Faublée, Jean-Pierre Flandrois, Yves Richard

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 279 ( 3 ) : 377-386

DOI: 10.1016/S0934-8840(11)80370-1

Journal article

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A statistical evaluation of the bactericidal effects of ceftibuten in combination with aminoglycosides and ciprofloxacin

F. Guérillot, G. Carret, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 32 ( 5 ) : 685-694

DOI: 10.1093/jac/32.5.685

Journal article

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[Comparative study of two systems for the determination of the sensitivity of yeasts to antifungal agents].

M de Montclos, H. de Montclos, Jean-Pierre Flandrois

Pathologie Biologie . 40 ( 5 ) : 495-9

Journal article

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Gram-positive infections in neutropenic patients: glycopeptide antibiotic choice

Monique Chomarat, Daniel Espinouse, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 29 ( 4 ) : 462-463

DOI: 10.1093/jac/29.4.462

Journal article

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Monod's bacterial growth model revisited

J.R. Lobry, Jean-Pierre Flandrois, G. Carret, A. Pavé

Bulletin of Mathematical Biology . 54(1) : 117-122

Journal article

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Maintenance requirements of Escherichia coli ATCC 25922 in the presence of sub-inhibitory concentrations of various antibiotics

J.R. Lobry, G. Carret, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 29 : 121-127

Journal article

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[Expert systems and antibiotic sensitivity test].

Jean-Pierre Flandrois, G. Carret

Annales de Biologie Clinique . 49 ( 3 ) : 166-71

Journal article

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Coagulase-negative staphylococci emerging during teicoplanin therapy and problems in the determination of their sensitivity

Monique Chomarat, Daniel Espinouse, Jean-Pierre Flandrois

Journal of Antimicrobial Chemotherapy . 27 ( 4 ) : 475-480

DOI: 10.1093/jac/27.4.475

Journal article

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A FORTRAN subroutine for the determination of parameter confidence limits in non-linear Models

J.R. Lobry, L. Rosso, Jean-Pierre Flandrois

Binary . 3 : 86-93

Journal article

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Susceptibility to Aminoglycosides of 63 Strains of Stomatococcus mucilaginosus Isolated from Sputum

Monique Chomarat, Marie-Gabrielle Vital, Jean-Pierre Flandrois

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 276 ( 1 ) : 63-67

DOI: 10.1016/S0934-8840(11)80219-7

Journal article

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Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B

M. Peyret, Jean-Pierre Flandrois, G. Fardel

Pathologie Biologie . 39 : 446-450

Journal article

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Comparison of estimates of Monod's growth model from the same data set

J.R. Lobry, Jean-Pierre Flandrois

Binary . 3 : 20-23

Journal article

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Biphasic kinetics of bacterial killing by quinolones

G. Carret, Jean-Pierre Flandrois, Jean R Lobry

Journal of Antimicrobial Chemotherapy . 27 ( 3 ) : 319-327

DOI: 10.1093/jac/27.3.319

Journal article

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Etude sur quatre ans des cas de yersiniose dans un service d'hépato-gastro-entérologie de la région lyonnaise

Jean-Pierre Flandrois, F. Bailly, M. Peyret, L. Descos

Médecine et Maladies Infectieuses . 21 : 371-375

DOI: 10.1016/S0399-077X(05)81308-3

Journal article

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[Influence of the culture medium (Isosensitest or Mueller-Hinton) on the results of antibiotics susceptibility testing and its interpretation].

Jean-Pierre Flandrois, M. Peyret, J Zindel

Pathologie Biologie . 39 ( 5 ) : 455-60

Journal article

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[Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B].

M. Peyret, Jean-Pierre Flandrois, G. Fardel

Pathologie Biologie . 39 ( 5 ) : 446-50

Journal article

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Preparation of a Latex Reagent for the Detection of Anti-Staphylococcus aureus Ribitol Teichoic Acid Antibodies

Michèle de Montclos, Jean-Pierre Flandrois

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 274 ( 1 ) : 50-60

DOI: 10.1016/S0934-8840(11)80974-6

Journal article

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[Mathematical study of the sensitivity curves of Escherichia coli exposed to polymyxins].

M. Peyret, G. Carret, C. Carré, G. Fardel, Jean-Pierre Flandrois

Pathologie Biologie . 38 ( 5 ) : 441-5

Journal article

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Mathematical study of the sensitivity curves of Escherichia coli exposed to polymyxins

M. Peyret, Jean-Pierre Flandrois, G. Fardel

Pathologie Biologie . 38 : 441-445

Journal article

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Isolation ofSporosarcina ureae from a bronchial biopsy in a child with cystic fibrosis

Jean-Pierre Flandrois, M. Chomarat, M. Montclos, F. Breysse

European Journal of Clinical Microbiology and Infectious Diseases . 9 ( 4 ) : 302-303

DOI: 10.1007/bf01968068

Journal article

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[Value of enzymuria during antibacterial therapy].

C Flandrois, Jean-Pierre Flandrois, D Coullioud, I Maire

Pathologie Biologie . 37 ( 5 Pt 2 ) : 657-63

Journal article

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Bacterial Strain Characterization Using Mathematical Modelling of Growth

Marie-Joëlle Rochet, Jean-Pierre Flandrois

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 271 ( 1 ) : 2-10

DOI: 10.1016/S0934-8840(89)80047-7

Journal article

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