GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 91 to 120 publications on 1402 in total

Genes and sites under adaptation at the phylogenetic scale also exhibit adaptation at the population-genetic scale

Thibault Latrille, Nicolas Rodrigue, Nicolas Lartillot

Proceedings of the National Academy of Sciences of the United States of America . 120 ( 11 ) : e2214977120

DOI: 10.1073/pnas.2214977120

Journal article

see the publication

Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery.

Adeline Robin, Céline Brochier-Armanet, Quentin Bertrand, Caroline Barette, Eric Girard, Dominique Madern

Molecular Biology and Evolution . msad223

DOI: 10.1093/molbev/msad223

Journal article

see the publication

Proposed mechanism for the selection of lactase persistence in childhood

Alexandre Fabre, Anne Fabre, Céline Bon, Paul Guerry, Laure Ségurel

BioEssays . 45 ( 7 )

DOI: 10.1002/bies.202200243

Journal article

see the publication

Bradyrhizobium commune sp. nov., isolated from nodules of a wide range of native legumes across the Australian continent

Bénédicte Lafay, Elina Coquery, Phil M. Oger

International Journal of Systematic and Evolutionary Microbiology . 73 ( 7 ) : 005971

DOI: 10.1099/ijsem.0.005971

Journal article

see the publication

Cophylogeny Reconstruction Allowing for Multiple Associations Through Approximate Bayesian Computation

Blerina Sinaimeri, Laura Urbini, Marie-France Sagot, Catherine Matias

Systematic Biology . : syad058

DOI: 10.1093/sysbio/syad058

Journal article

see the publication

Hybrid modelling to Solve Optimal Concentrations of Metabolites and Enzymes in Constraint-based modelling

Sabine Peres

BIOSTEC 2023 .

Conference paper

see the publication

Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

see the publication

Self-compassion and savouring buffer the impact of the first year of the COVID-19 on PhD students' mental health

Marine Paucsik, Christophe Leys, Gabriel Marais, Céline Baeyens, Rebecca Shankland

Stress and Health .

DOI: 10.1002/smi.3142

Journal article

see the publication

Dosage compensation evolution in plants: theories, controversies and mechanisms

Aline Muyle, Gabriel Ab Marais, Václav Bačovský, Roman Hobza, Thomas Lenormand

Philosophical Transactions of the Royal Society B: Biological Sciences . 377 ( 1850 ) : 20210222

DOI: 10.1098/rstb.2021.0222

Journal article

see the publication

MacSyFinder v2: An improved search engine to model and identify molecular systems in genomes

Bertrand Néron, Rémi Denise, Charles Coluzzi, Marie Touchon, Eduardo Rocha, Sophie Abby

JOBIM .

Poster

see the publication

ICEscreen: a valuable tool for automatic detection of ICEs and IMEs in Firmicutes

Nathalie N. Leblond-Bourget, Julie Lao, Sophie Payot, Thomas Lacroix, Gérard Guédon, Charles Coluzzi...

Réunion du GDR3546 Eléments transposables .

Conference paper

see the publication

ICEscreen: a tool to detect Firmicute ICEs and IMEs, isolated or enclosed in composite structures

Julie Lao, Thomas Lacroix, Gérard Guédon, Charles Coluzzi, Sophie Payot, Nathalie Leblond-Bourget...

NAR Genomics and Bioinformatics . 4 ( 4 ) : lqac079

DOI: 10.1093/nargab/lqac079

Journal article

see the publication

NAR Breakthrough Article Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation

Manuel Ares-Arroyo, Charles Coluzzi, Eduardo P.C. Rocha

Nucleic Acids Research . 51 ( 7 ) : 3001–3016

DOI: 10.1093/nar/gkac1079

Journal article

see the publication

Streptococcus suis as a reservoir of antibiotic resistance genes carried by Mobile Genetic Elements transferring by conjugation

Sophie Payot, Virginie Libante, Yves Nombre, Charles Coluzzi, Johan Staub, Gérard Guédon...

5th International Caparica Congress in Antibiotic Resistance (IC2AR 2022) .

Conference paper

see the publication

Evolution of Plasmid Mobility: Origin and Fate of Conjugative and Nonconjugative Plasmids

Charles Coluzzi, Maria Pilar Garcillán-Barcia, Fernando de la Cruz, Eduardo P.C. Rocha

Molecular Biology and Evolution . 39 ( 6 ) : msac115

DOI: 10.1093/molbev/msac115

Journal article

see the publication

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium

Helit Cohen, Claire Hoede, Felix Scharte, Charles Coluzzi, Emiliano Cohen, Inna Shomer...

PLoS Pathogens . 18 ( 4 ) : 35 p.

DOI: 10.1371/journal.ppat.1010425

Journal article

see the publication

ICEscreen

Hélène Chiapello, Charles Coluzzi, Nathalie N. Leblond-Bourget, Thomas Lacroix, Julie Lao, Gérard Guédon

Software

see the publication

The assembly of the rice weevil Sitophilus oryzae is dominated by transposable elements and shades light on the evolution of endosymbiosis in a major crop pest.

Nicolas Parisot, Carlos Vargas-Chávez, Clément Goubert, Patrice Baa-Puyoulet, Severine Balmand, Louis Beranger...

Arthropod Genomics Symposium 2022 .

Conference paper

see the publication

Modelling the spatiotemporal spread of beneficial alleles using ancient genomes

Rasa Muktupavela, Martin Petr, Laure L. Segurel, Thorfinn Korneliussen, John Novembre, Fernando Racimo

DOI: 10.1101/2021.07.21.453231

Preprint

see the publication

Interpreting mismatches between linguistic and genetic patterns among speakers of Tanimuka (Eastern Tukanoan) and Yukuna (Arawakan)

Leonardo Arias, Nicholas Q Emlen, Sietze Norder, Nora Julmi, Magdalena Lemus Serrano, Thiago Chacon...

Interface Focus . 13

DOI: 10.1098/rsfs.2022.0056

Journal article

see the publication

Ethical challenges in genetic research among Philippine Indigenous Peoples: Insights from fieldwork in Zamboanga and the Sulu Archipelago

Jae Joseph Russell B Rodriguez, John Meldwin D Cuales, Michael James B Herrera, Louward Allen M Zubiri, Richard N. Muallil, Altan I. Ishmael...

Frontiers in Genetics . 13 : 901515

DOI: 10.3389/fgene.2022.901515

Journal article

see the publication

The transmission of human mitochondrial DNA in four‐generation pedigrees

Qi Liu, Muhammad Faaras Iqbal, Tahir Yaqub, Sehrish Firyal, Yiqiang Zhao, Mark Stoneking...

Human Mutation . 43 : 1259-1267

DOI: 10.1002/humu.24390

Journal article

see the publication

The social lives of isolates (and small language families): the case of the Northwest Amazon

Rik van Gijn, Sietze Norder, Leonardo Arias, Nicholas Q Emlen, Matheus C B C Azevedo, Allison Caine...

Interface Focus . 13 ( 1 ) : 20220054

DOI: 10.1098/rsfs.2022.0054

Journal article

see the publication

Assessing Human Genome-wide Variation in the Massim Region of Papua New Guinea and Implications for the Kula Trading Tradition

Dang Liu, Benjamin M Peter, Wulf Schiefenhövel, Manfred Kayser, Mark Stoneking

Molecular Biology and Evolution . 39

DOI: 10.1093/molbev/msac165

Journal article

see the publication

Ancient genomes from the last three millennia support multiple human dispersals into Wallacea

Sandra Oliveira, Kathrin Nägele, Selina Carlhoff, Irina Pugach, Toetik Koesbardiati, Alexander Hübner...

Nature Ecology & Evolution . 6 : 1024 - 1034

DOI: 10.1038/s41559-022-01775-2

Journal article

see the publication

A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size

Rebekka Müller, Ingemar Kaj, Carina Mugal

Genome Biology and Evolution . 14 ( 5 )

DOI: 10.1093/gbe/evac058

Journal article

see the publication

Hydrogen isotope measurements of bone and dental tissues from archaeological human and animal samples and their use as climatic and diet proxies

Thibault Clauzel, Pascale Richardin, Jannick Ricard, Yves Le Béchennec, Romain Amiot, François Fourel...

Journal of Archaeological Science . 147 : 105676

DOI: 10.1016/j.jas.2022.105676

Journal article

see the publication

Climate conditions and dietary practices during the Second Iron Age studied through the multi-isotope analysis of bones and teeth from individuals of Thézy-Glimont, Picardie, France

Thibault Clauzel, Pascale Richardin, Jannick Ricard, Yves Le Béchennec, Romain Amiot, François Fourel...

Archaeological and Anthropological Sciences . 14 ( 4 ) : 61

DOI: 10.1007/s12520-022-01534-1

Journal article

see the publication

Modeling the spatiotemporal spread of beneficial alleles using ancient genomes

Rasa Muktupavela, Martin Petr, Laure Ségurel, Thorfinn Korneliussen, John Novembre, Fernando Racimo

eLife . 11

DOI: 10.7554/eLife.73767

Journal article

see the publication

Polynomial Delay Algorithm for Minimal Chordal Completions

Caroline Brosse, Vincent Limouzy, Arnaud Mary

49th International Colloquium on Automata, Languages, and Programming (ICALP) .

DOI: 10.4230/LIPIcs.ICALP.2022.33

Conference paper

see the publication