COEVOL Multi-Scale Coevolution

Evolutionary Genetics of Interactions Group

The Cocoon Group

Living systems are highly integrated, with a multitude of levels of organization, from molecular and intra-cellular scales to ecosystems. Complex organisms are themselves consortia of macro- and micro-organisms, which work together with their host to build the individual. Yet, each of these organisms can function and evolve in the short term according to its own logic, possibly in conflict with other higher or lower levels, or with other time scales. The once common idea among evolutionists that natural selection results in organisms perfectly adapted to their environment is now severely undermined. Not only because, as the Red Queen explains to Alice, one has to run relentlessly to keep its place in a changing environment, or because past evolutionary history and chance constrain the possibilities of present adaptation, but also because different levels of selection have interests that are generally difficult to reconcile.

Multi-scale coevolution resets classical questions in evolutionary biology

One example, of particular interest is the question of the source of heritable variations. The phenotype of organisms in a population is influenced not only by variations in their nuclear and mitochondrial genomes, the dynamics of which is the object of population genetics, but also more and more patently by the consortium of microbes and genetic elements that constitute its microbiome and virome. The hologenome designates this complex assembly of genetic materials, which obey different rules of transmission and different evolutionary strategies. The ability of symbionts to manipulate host phenotypes or to interfere with each other influences the evolutionary dynamics of all players in ways that are yet poorly understood. In addition, new questions arise, such as the importance of co-adaptation in these systems and their consequences in maintaining cohesive biological systems.

  •  Symbiosis: a response to and a source of divergent selection

Using a variety of approaches combining experimental evolution, genomic, functional, phenotypic and behavioral data, we aim to test whether symbiosis facilitates diversification and to characterize the underlying microevolutionary processes.

  •  Ecological networks of horizontal gene transfer

We develop original methods to detect gene transfer and we investigate the factors that influence the routes of gene transfers among microbes but also among insects.

  •  The interplay between symbiosis, infection and immunity and its evolutionary consequences

We try to understand the intimate interaction of hosts with pathogens, symbionts and transposable elements and how it affects the extended phenotype of the host.

  • Transgenerational inheritance and environment changes

We try to decipher the molecular mechanisms that underlie rapid adaptation to environment and to test for transgenerational inheritance of fitness traits.

  •  Intragenomic conflicts and demography

We are developing models to test whether changes in the demography of the host affect the dynamics of transposable elements.

  • The determinism of phenotypic convergence

We study the genomic basis of convergent phenotypic evolution in particular in the case of animals and plants adaptation to increasing temperature and decreasing water.

  • Reconciling the tree of life

We develop phylogenetic methods for “reconciling” gene/species or host/symbiont histories and use these methods to explore the bulk of extinct or undescribed species and the history of association of symbiotic microbes with their hosts.

Integrating methods

The methods we use to tackle the questions raised by multi-scale co-evolution extend from theory, modelling and simulation to big data analysis, lab (notably on insects), and to a lesser extent, field activities.

Implication of research, responsibility of researchers and citizen sciences

From our research (some of which have immediate consequences in health, agriculture and ecology) and our concerns about the responsibility of scientists in society, we are committed to promote an “implicative” research. The implicative position means that we try to work on the link between science and society, not only through a one-way communication, applying or explaining our science, but also favoring early discussions on research projects, that may influence our research directions.

Publications

Display of 121 to 150 publications on 748 in total

Role of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the sap-feeder Bemisia tabaci

Sylvain Benhamou, Isabelle Rahioui, Hélène Henri, Hubert Charles, Pedro da Silva, Abdelaziz Heddi...

DECRYPthèse E2M2 Edition 20 .

Conference paper

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Role of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae)

Sylvain Benhamou, Isabelle Rahioui, Hélène Henri, Hubert Charles, Pedro da Silva, Abdelaziz Heddi...

G-RREMI 2021 - Groupe Régional de Recherche en Microbiologie des Interactions .

Conference paper

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The transposable element-rich genome of the cereal pest Sitophilus oryzae

Nicolas Parisot, Carlos Vargas-Chávez, Clément Goubert, Patrice Baa-Puyoulet, Séverine Balmand, Louis Beranger...

BMC Biology . 19 ( 1 ) : 241

DOI: 10.1186/s12915-021-01158-2

Journal article

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Chromosomal scale assembly of parasitic wasp genome reveals symbiotic virus colonization

Jérémy Gauthier, Hélène Boulain, Joke J F A van Vugt, Lyam Baudry, Emma Persyn, Jean-Marc Aury...

Communications Biology . 4 ( 1 ) : 1-15

DOI: 10.1038/s42003-020-01623-8

Journal article

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In vivo MRI characterization of the Xlf-/- mouse model of genetic radiosensitivity following low-dose in utero irradiation

Laurence Mouton, O. Etienne, J. Feat-Vetel, D. Barrière, E.A. Pérès, J-P de Villartay...

European Society for Magnetic Resonance in Medicine and Biology (ESMRMB Congress 2020) .

Conference paper

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La tête de « Jupiter capitolin » de Fréjus (Forum Iulii)

Yvon Lemoine, Florian Blanchard

Revue archéologique de Narbonnaise . ( 53 ) : 239-266

Journal article

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Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses

Martin Kapun, Maite G Barrón, Fabian Staubach, Darren J Obbard, R Axel W Wiberg, Jorge Vieira...

Molecular Biology and Evolution . 37 ( 9 ) : 2661-2678

DOI: 10.1093/molbev/msaa120

Journal article

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Superparasitism by a parasitoid wasp: The absence of sublethal effects from the neonicotinoid insecticide imidacloprid enlightens the specificity of the cholinergic pathway involved

Jean-Marie Delpuech

Ecotoxicology and Environmental Safety . 201 : 110809

DOI: 10.1016/j.ecoenv.2020.110809

Journal article

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Endosymbiont diversity in natural populations of Tetranychus mites is rapidly lost under laboratory conditions

Flore Zélé, Inês Santos, Margarida Matos, Mylène Weill, Fabrice Vavre, Sara Magalhaes

Heredity . 124 ( 4 ) : 603-617

DOI: 10.1038/s41437-020-0297-9

Journal article

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Treerecs: an integrated phylogenetic tool, from sequences to reconciliations.

Nicolas Comte, Benoît Morel, Damir Hasic, Laurent Guéguen, Bastien Boussau, Vincent Daubin...

Bioinformatics . 36 ( 18 ) : 4822-4824

DOI: 10.1093/bioinformatics/btaa615

Journal article

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Reconciling Gene trees with Species Trees

Bastien Boussau, Celine Scornavacca

Phylogenetics in the Genomic Era . : 3.2:1--3.2:23

Book chapter

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Combining sterile and incompatible insect techniques for the population suppression of Drosophila suzukii

K. Nikolouli, F. Sassù, L. Mouton, C. Stauffer, K. Bourtzis

Journal of Pest Science . 93 ( 2 ) : 647 - 661

DOI: 10.1007/s10340-020-01199-6

Journal article

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How consistent is RAD‐seq divergence with DNA‐barcode based clustering in insects?

Marie Cariou, Hélène Henri, Sonia Martinez, Laurent Duret, Sylvain Charlat

Molecular Ecology Resources . 20 ( 5 ) : 1294-1298

DOI: 10.1111/1755-0998.13178

Journal article

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Ancestral Genome Organization as a Diagnosis Tool for Phylogenomics

Eric Tannier, Adelme Bazin, Adrián Davín, Laurent Guéguen, Sèverine Bérard, Cedric Chauve

Phylogenetics in the Genomic Era . : 2.5:1--2.5:19

Book chapter

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Homology-Free Detection of Transposable Elements Unveils Their Dynamics in Three Ecologically Distinct Rhodnius Species

Marcelo Castro, Clément Goubert, Fernando Monteiro, Cristina Vieira, Claudia Carareto

Genes . 11 ( 2 ) : 170

DOI: 10.3390/genes11020170

Journal article

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DGINN, an automated and highly-flexible pipeline for the detection of genetic innovations on protein-coding genes

Lea Picard, Quentin Ganivet, Omran Allatif, Andrea Cimarelli, Laurent Guéguen, Lucie Etienne

Nucleic Acids Research . 48 ( 18 ) : e103-e103

DOI: 10.1093/nar/gkaa680

Journal article

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A behavior-manipulating virus relative as a source of adaptive genes for Drosophila parasitoids

D Di Giovanni, D. Lepetit, B Guinet, B Bennetot, M. Boulesteix, Yohann Couté...

Molecular Biology and Evolution . 37 ( 10 ) : 2791-2807

DOI: 10.1093/molbev/msaa030

Journal article

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Experimental evolution of virulence and associated traits in a Drosophila melanogaster - Wolbachia symbiosis

David Monnin, Natacha Kremer, Caroline Michaud, Manon Villa, Hélène Henri, Emmanuel Desouhant...

Peer Community In Evolutionary Biology . : e9

DOI: 10.24072/pcjournal.9

Journal article

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A transposon story : from TE content to TE dynamic invasion of Drosophila genomes using the single-molecule sequencing technology from Oxford Nanopore

Mohamed Mourdas, Nguyet Thi-Minh Dang, Yuki Ogyama, Nelly Burlet, Bruno Mugat, Matthieu Boulesteix...

Cells . 9 ( 8 ) : 1776

DOI: 10.3390/cells9081776

Journal article

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Viral infection impacts transposable element transcript amounts in Drosophila

Marlène Roy, Barbara Viginier, Edouard Saint-Michel, Frederick Arnaud, Maxime Ratinier, Marie Fablet

Proceedings of the National Academy of Sciences of the United States of America . 117 ( 22 ) : 12249-12257

DOI: 10.1073/pnas.2006106117

Journal article

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Syndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?

Jordan Teoli, Claire Bardel, Marie Fablet, Gabriel Marais, François Gueyffier, Jean-François Lemaître...

36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194

DOI: 10.1016/j.ando.2020.07.150

Conference paper

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Wolbachia host shifts: routes, mechanisms, constraints and evolutionary consequences

Ehsan Sanaei, Sylvain Charlat, Jan Engelstädter

Biological Reviews .

DOI: 10.1111/brv.12663

Journal article

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L’épistémologie des sciences biologiques et géologiques : une occasion d’enseigner l’incertitude ?

Fabienne Paulin, Sylvain Charlat

Raisons éducatives . N°24

DOI: 10.3917/raised.024.0101

Journal article

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Genome Evolution: Mutation Is the Main Driver of Genome Size in Prokaryotes

Gabriel A.B. Marais, Bérénice Batut, Vincent Daubin

Current Biology - CB . 30 ( 19 ) : R1083-R1085

DOI: 10.1016/j.cub.2020.07.093

Journal article

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