The Cocoon Group

Members

Le Cocon is both a research team and a think tank. 

Research in “Le Cocon” team focuses on two main topics: multiscale evolution on one hand (i.e., studying the evolution of genetic systems while considering different levels -nucleotides, transposable elements, genes, genomes, microbiomes, organisms, populations, species, geography-), and environmental issues on the other hand. In both cases, we rely on modeling and data analysis, using a combination of statistics and computer science.

Le Cocon is also a place to think about the responsibilities of research and researchers in the anthropocene era, and about the role of non-researcher citizens in orienting and conducting research.

Multiscale evolution

  • We have a long history of working on gene transfers. We develop new methods to detect these events in complex systems involving more than two levels (host, symbiont and parasites for example) and
  • We use horizontal transfer detection to date species trees and to infer yet unknown biodiversity (extinct and unsampled) (Sthoriz (ANR, 2018)) .
  • We have a lasting interest into convergent genomic evolution (Convergenomics - ANR, 2015)
  • We question the usual way of testing bioinformatic methods (Evoluthon - ANR, 2019)
  • We study the interaction between human populations, their lifestyles, and their gut microbiota (Microregal - ANR, 2015). We are notably interested in identifying cases of host-microbe coevolution and in better understanding transmission dynamics.

Environmental issues

  • We develop computational methods to support an agriculture that relies on ecosystemic relationships between crops, the soil, its microbiota, and wild plants and animals (Community Garden Book - Inria, 2019)
  • We develop statistical approaches to understand and predict crop yield variability with respect to meteorological conditions

Research in the anthropocene

  • We participate to the science shop (UdL), the ethics platform (UdL), Labo1.5, the open science committee, Sciences Citoyennes, the shift project
  • We organize a series of seminars to help us think about the position of scientific research in the history of the anthropocene, and about the position of scientists in the future of the anthropocene.
  • We assemble committees of citizens to investigate to what extent scientific research can be democratized.

Teaching and outreach

  • We teach at University of Lyon, University Lyon 1, INSA, Inria, ENS Lyon, we organize bioinformatics internships 
  • We regularly participate in the Fête de la Science, have contributed videos in the public transportation system in Lyon, give conferences at Université Populaire and contribute articles in general public journals.
  • We develop the software Lifemap to explore the tree of life on computers and smartphones.

 
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.

Publications

Display of 181 to 210 publications on 311 in total

Efficient selection of branch-specific models of sequence evolution.

Julien y Dutheil, Nicolas Galtier, Jonathan Romiguier, Emmanuel J.P. Douzery, Vincent Ranwez, Bastien Boussau

Molecular Biology and Evolution . 29 ( 7 ) : 1861-1874

DOI: 10.1093/molbev/mss059

Journal article

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A Phylogenomic Approach to Vertebrate Phylogeny Supports a Turtle-Archosaur Affinity and a Possible Paraphyletic Lissamphibia

Jj. Fong, Jm. Brown, Mk. Fujita, Bastien Boussau

PLoS ONE . 7 : e48990

DOI: 10.1371/journal.pone.0048990

Journal article

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Linkage to the mating-type locus across the genus microbotryum: insights into nonrecombining chromosomes

Elsa Petit, Tatiana Giraud, Damien M. de Vienne, Marco A Coelho, Gabriela Aguileta, Joelle J. Amselem...

Evolution - International Journal of Organic Evolution . 66 ( 11 ) : 3519-3533

DOI: 10.1111/j.1558-5646.2012.01703.x

Journal article

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Evolution of Prokaryotic Pangenomes

Florent Lassalle, Vincent Daubin

Horizontal Gene Transfer in Microorganisms . 978-1-908230-10-2 : 23-32

Book chapter

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Disentangling the effects of breakdown of self-incompatibility and transition to selfing in North-American Arabidopsis lyrata

A. Haudry, H.G. Zha, M. Stift, B.K. Mable

Molecular Ecology . 21 : 1130-1142

DOI: 10.1111/j.1365-294X.2011.05435.x

Journal article

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Linearization of ancestral multichromosomal genomes

Ján Maňuch, Murray Patterson, Roland Wittler, Cedric Chauve, Eric Tannier

BMC Bioinformatics . 13 ( Suppl 19 ) : S11

DOI: 10.1186/1471-2105-13-S19-S11

Journal article

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Evolution of gene neighborhoods within reconciled phylogenies

Sèverine Bérard, Coralie Gallien, Bastien Boussau, Gergely J Szöllosi, Vincent Daubin, Eric Tannier

Bioinformatics . 28 ( 18 ) : i382-i388

DOI: 10.1093/bioinformatics/bts374

Journal article

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Lateral gene transfer as a support for the tree of life.

Sophie S Abby, Eric Tannier, Manolo Gouy, Vincent Daubin

Proceedings of the National Academy of Sciences of the United States of America . 109 ( 13 ) : 4962-4967

DOI: 10.1073/pnas.1116871109

Journal article

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High-quality sequence clustering guided by network topology and multiple alignment likelihood.

Vincent Miele, Simon Penel, Vincent Daubin, Franck Picard, Daniel Kahn, L. Duret

Bioinformatics . 28 ( 8 ) : 1078-85

DOI: 10.1093/bioinformatics/bts098

Journal article

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Genomic Species Are Ecological Species as Revealed by Comparative Genomics in Agrobacterium tumefaciens

Florent Lassalle, Tony Campillo, Ludovic Vial, Jessica Baude, Denis Costechareyre, David Chapulliot...

Genome Biology and Evolution . 3 ( 3 ) : 762-781

DOI: 10.1093/gbe/evr070

Journal article

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Models, algorithms, and programs for phylogeny reconciliation

Jean-Philippe Doyon, Vincent Ranwez, Vincent Daubin, Vincent Berry

Briefings in Bioinformatics . 12 ( 5 ) : 392-400

DOI: 10.1093/bib/bbr045

Journal article

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Multiple Nuclear Gene Phylogenetic Analysis of the Evolution of Dioecy and Sex Chromosomes in the Genus Silene

Gabriel Marais, A. Forrest, E. Kamau, Jos Käfer, Vincent Daubin, D. Charlesworth

PLoS ONE . 6 : e21915

DOI: 10.1371/journal.pone.0021915

Journal article

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HDR - Evolution combinatoire Algorithmique des chromosomes

Eric Tannier

incollection . -- : 54-56

Journal article

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Euclidean nature of phylogenetic distance matrices

Damien M. de Vienne, Gabriela Aguileta, Sébastien Ollier

Systematic Biology . 60 ( 6 ) : 826--832

DOI: 10.1093/sysbio/syr066

Journal article

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Tpms: a Tree Pattern-matching Utility for Querying Gene Trees Collections

Thomas Bigot, Vincent Daubin, G. Perrière

Journées Ouvertes Biologie Informatique Mathématiques (JOBIM) . : 111-112

Conference paper

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Mapping ancestral genomes with massive gene loss: a matrix sandwich problem.

Haris Gavranović, Cedric Chauve, Jérôme Salse, Eric Tannier

Bioinformatics . 27 ( 13 ) : i257-65

DOI: 10.1093/bioinformatics/btr224

Journal article

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L'époque romantique contre la peine de mort

Eric Tannier

incollection . -- : 54-56

Journal article

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Preface : Satellite Workshop on Comparative Genomics Research in Computational Molecular Biology (RECOMB-CG 2010)

Eric Tannier

Journal of Computational Biology . 18(9) : 1-3

Journal article

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Evolution Combinatoire, Algorithmique des Chromosomes

Eric Tannier

HDR

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L'époque romantique contre la peine de mort

Eric Tannier

978-613-1-56487-1 : 176

Book

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La notion d'espèce en écologie microbienne

T. Campillo, Malek Shams, Sally Burr, Martha Helena Ramírez-Bahena, Florent Lassalle, Franck Bertolla...

1er Colloque National d'Ecologie Scientifique .

Conference paper

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Toward an ecological concept for bacterial species in Agrobacterium

Tony Campillo, Florent Lassalle, M. Shams, Martha Helena Ramírez-Bahena, Jessica Baude, Celine Lavire...

12th International Conference on Plant Pathogenic Bacteria .

Conference paper

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Identification de fonctions « spécifiques d'espèce » impliquées dans l'individualisation en écovar de l’espèce G8 du complexe Agrobacterium tumefaciens

Florent Lassalle, Daniel Muller, Denis Costechareyre, David Chapulliot, Celine Lavire, Laurent Guéguen...

Journées des Microbiologistes de l'INRA .

Conference paper

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Evolution Moléculaire

L. Duret, T. Bataillon, N. Bierne, Vincent Daubin, J. Dutheil, Christian Gautier...

Biologie évolutive . 978-2-8041-0161-9 : 114-173

Book chapter

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Detecting lateral gene transfers by statistical reconciliation of phylogenetic forests

Sophie S. Abby, Eric Tannier, Manolo Gouy, Vincent Daubin

BMC Bioinformatics . 11 ( 324 ) : 13

DOI: 10.1186/1471-2105-11-324

Journal article

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