GECO Génomique Computationnelle et Evolutive

Equipe Bioinformatique, Phylogénie et Génomique Evolutive

Flandrois Jean-Pierre

Professeur d'université émérite

UCBL

Adresse : 43 Bd du 11 novembre 1918
69622 VILLEURBANNE

Tél : 04 72 44 85 60

Courriel

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My Research

Two flagship projects

BIBI-DB BIBI-DB is a taxonomy-hierarchized set of databases and oriented to facilitate the phylogeny of Archaea and Bacteria. Thanks to a web interface it allows the phylogenetic placement of unknown nucleic acid sequences (this may precede identification). RiboDB is a ribosomal protein database of Bacteria and Archaea freely searchable via the Internet. RiboDB construction process is versatile and can be used to construct proteins databases from freshly assembled and annotated genomes.

Applications

leBIBI is a web application used worldwide to identify bacteria in hospital laboratories, industrial, environmental.
The leBIBI and RiboDB databases are useful to classify more rigorously the Bacteria and Archaea and may highlight new pathogen species. Their use helps to explain the evolution of the microbial world. RiboDB will allow to improve the quality of diagnosis of infections. 

Ancient Ecosystems and stable isotopes

I am very pleased to cooperate since 2012 in some work Christophe Lecuyer and his team as a physiologist, biologist and physician. This topic is now a real scientific center of interest for me!

The first studies were on ancient climates reconstruction by using the informations recorded in bone and teeth of egyptian mummies but of course we get also informations on human and animal nutrition. 
Climate reconstruction may also be done outside egypt with other types of samples.

We were also proud to show that the hatching temperature of Oviraptosaurs were not so different from that of actual birds... 

 

Medical microbiology

This are works I have initiated or using datas that have been collected during my previous position as Head of the Microbiology Laboratory CH Lyon-Sud 1979-2013.

Publications

Affichage des publications 121 à 137 sur 137 au total

[Bacteriostatic and bactericidal antibiotics: differences in subinhibitory concentration effects on the growth of Escherichia coli].

S Comby, G. Carret, A. Pavé, Jean-Pierre Flandrois, C. Pichat

Pathologie Biologie . 37 ( 5 ) : 335-40

Article dans une revue

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Mathematical modelling of growth of Escherichia coli at subinhibitory levels of chloramphenicol or tetracyclines

Jean-Pierre Flandrois, S. Comby, J.P. Flandrois, G. Carret, C. Pichat

Research in Microbiology . 140 ( 3 ) : 243-254

DOI: 10.1016/0923-2508(89)90079-X

Article dans une revue

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[Interpretative reading and quality control of an antibiotic sensitivity test using an expert system. Application to the API ATB system and Enterobacteriaceae].

M. Peyret, Jean-Pierre Flandrois, G. Carret, C. Pichat

Pathologie Biologie . 37 ( 5 Pt 2 ) : 624-8

Article dans une revue

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Study of staphylococcus aureus teichoic acid immunodominant site by help of synthetic haptens

Michèle Pérouse de Montclos, Paul Boullanger, Jean-Pierre Flandrois

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology . 267 ( 3 ) : 414-424

DOI: 10.1016/S0176-6724(88)80058-0

Article dans une revue

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Mathematical modelling of bacterial growth at subinhibitory levels of aminoglycosides

Jean-Pierre Flandrois, S Comby, G. Carret, C. Pichat

Annales de l'Institut Pasteur / Microbiologie . 139 ( 5 ) : 613-629

DOI: 10.1016/0769-2609(88)90159-7

Article dans une revue

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[An expert system as an aid to the validation of results of the antibiogram. Feasibility study based on the example of Staphylococcus aureus].

S Comby, Jean-Pierre Flandrois, A. Pavé

Pathologie Biologie . 36 ( 5 ) : 381-5

Article dans une revue

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[Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032].

Jean-Pierre Flandrois, G. Carret, M. Peyret, Catherine Pichat

Pathologie Biologie . 36 ( 5 ) : 377-80

Article dans une revue

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[A mathematical study of the mortality curve of Escherichia coli exposed to aminoglycosides].

Jean-Pierre Flandrois, G. Carret, G. Fardel

Pathologie Biologie . 36 ( 5 ) : 446-51

Article dans une revue

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Corynebacterium JK: surgical infections in non-immunosuppressed patients

Jean-Pierre Flandrois, A. Lepape, P.Y. Carry, M. Chomarat, J.P. Perdrix, J.M. Grozel...

Intensive Care Medicine . 15 ( 1 )

DOI: 10.1007/bf00255631

Article dans une revue

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[Use of an expert system as a tool to carry out urinary cyto-bacteriologic tests].

S Comby, G. Carret, Jean-Pierre Flandrois, A. Pavé, M Perouse de Montclos

Annales de Biologie Clinique . 46 ( 8 ) : 669-72

Article dans une revue

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Early stages of in vitro killing curve of LY146032 and vancomycin for Staphylococcus aureus.

Jean-Pierre Flandrois, Ghislaine Fardel, G. Carret

Antimicrobial Agents and Chemotherapy . 32 ( 4 ) : 454-457

DOI: 10.1128/AAC.32.4.454

Article dans une revue

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[Effect of subinhibitory concentrations of antibiotics on the growth level of bacteria].

G. Carret, B Charpe, A Cheruy, Jean-Pierre Flandrois, A. Pavé, C Couix

Pathologie Biologie . 35 ( 5 ) : 483-93

Article dans une revue

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Bacterial growth measurement using an automated system: Mathematical modelling and analysis of growth kinetics

Jean-Pierre Flandrois, A. Corman, G. Carret, A. Pavé, C. Couix

Annales de l'Institut Pasteur / Microbiologie . 137 ( 1 ) : 133-143

DOI: 10.1016/S0769-2609(86)80102-8

Article dans une revue

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[Evaluation of the Rapid-ATB system for testing the sensitivity of staphylococci to antibiotics. Comparison with the agar dilution reference method].

P Le Noc, G. Carret, C. Couix, Jean-Pierre Flandrois, J Gayral, J. Robert

Pathologie Biologie . 34 ( 5 Pt 2 ) : 600-3

Article dans une revue

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Gelatin and collagen binding to Staphylococcus aureus strains.

G. Carret, H. Emonard, G. Fardel, M. Druguet, D. Herbage, Jp Flandrois

Ann Inst Pasteur Microbiol . 136A : 241-245

Article dans une revue

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[Nonparametric approach to the determination of critical diameters. Comparison with conventional methods].

Jean-Pierre Flandrois, G. Carret

Pathologie Biologie . 32 ( 5 Pt 2 ) : 488-91

Article dans une revue

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Evolution de la résistance aux antibiotiques des agents infectieux en milieu hospitalier

J Fleurette, S Chassignol, A Moulin, A Biron, Jean-Pierre Flandrois

Bulletin de l'Institut national de la sante et de la recherche medicale . 25 ( 5 ) : 963-92

Article dans une revue

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